Managed by Massimo Federici.
This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D).
Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients.
cIMT progression, defined as percentage (%) change of cIMT from baseline, correlated inversely with the % changes of both CAC (p = 0.04, r = − 0.3; n = 62) and FMD (p = 0.03, r = − 0.3; n = 47). In multivariate analysis, RTI frequency correlated significantly with cIMT progression irrespective of age, diabetes duration, BMI, and HbA1c (p = 0.03, r = 0.3). When patients were divided in relation to RTI, the association of DQ2/8 with cIMT progression remained significant in patients with over three infections/year (p = 0.04, r = 0.3). During follow-up, the group of DQ2/8 patients with hsCRP > 1 mg/l showed significantly higher levels of plasma MMP-8 than the non-DQ2/8 group.
The diabetes-risk genotype DQ2/8 and systemic inflammation contribute to pro-atherosclerotic vascular changes in children and adolescents with T1D.
Odermarsky M, Sjöblad S, Nilsson A, Lernmark A, Liuba P (2007) Atherogenic vascular and lipid phenotypes in young type 1 diabetics are associated with diabetes high risk HLA genotype. Am J Physiol Heart Circ Physiol 293:3175–3179 CrossRef
- HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes
Pirkko J. Pussinen
- Springer Milan
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