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Archives of Gynecology and Obstetrics
Erschienen in: Archives of Gynecology and Obstetrics 3/2012

01.03.2012 | General Gynecology

Hormone replacement therapy: relation to homocysteine and prooxidant-antioxidant status in healthy postmenopausal women

verfasst von: Cahide Gökkuşu, Zeynep Özbek, Gülten Tata

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 3/2012

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Abstract

Objectives

Studies have consistently shown a lower cardiovascular risk in women who received postmenopausal hormone replacement therapy (HRT).

Design and Methods

In this study, the effects of HRT were investigated on plasma total homocysteine (tHcy) and the oxidant-antioxidant status in postmenopausal women. 35 of postmenopausal receiving (2 mg estrodiol valerate + 1 mg cyproterone acetate) HRT group, the remaining 25 received orally placebo (NHRT group).

Results

There was no significant change in plasma tHcy levels between HRT and NHRT groups. Malondialdehyde (MDA) and total thiol (t-SH) correlated significantly with tHcy (0.388 and 0.478, respectively) content, and there was a significant negative correlation between E2 level and glutathione transferase (GST) activity (−0.425) in HRT group. Superoxide dismutase (SOD) and HDL-C correlated significantly with t-SH level (0.339 and 0.336, respectively) in plasma after HRT.

Conclusion

Our results show that HRT is beneficial in the protection against oxidative damage, and prevents atherosclerotic complications.
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Metadaten
Titel
Hormone replacement therapy: relation to homocysteine and prooxidant-antioxidant status in healthy postmenopausal women
verfasst von
Cahide Gökkuşu
Zeynep Özbek
Gülten Tata
Publikationsdatum
01.03.2012
Verlag
Springer-Verlag
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 3/2012
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-011-2051-2

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