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Erschienen in: Critical Care 4/2010

01.08.2010 | Commentary

Hot times in the intensive care unit

verfasst von: Edward Abraham

Erschienen in: Critical Care | Ausgabe 4/2010

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Abstract

Fever is a common occurrence in the intensive care unit, and pharmacologic approaches are limited, particularly in patients unable to tolerate enteral medications. Although a study by Morris and colleagues in the previous issue of Critical Care suggests that intravenous ibuprofen is safe and effective in critically ill patients, the study is small and the drug was given over only a 24-hour period. Additional studies will need to be performed to demonstrate the safety and efficacy of intravenous ibuprofen in critically ill patients.
Literatur
1.
Zurück zum Zitat Morris PE, Promes JT, Guntupalli KK, Wright PE, Arons MM: A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adults. Crit Care 2010, 14: R125. 10.1186/cc9089PubMedCentralCrossRefPubMed Morris PE, Promes JT, Guntupalli KK, Wright PE, Arons MM: A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adults. Crit Care 2010, 14: R125. 10.1186/cc9089PubMedCentralCrossRefPubMed
2.
Zurück zum Zitat Bernard GR, Wheeler AP, Russell JA, Schein R, Summer WR, Steinberg KP, Fulkerson WJ, Wright PE, Christman BW, Dupont WD, Higgins SB, Swindell BB: The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med 1997, 336: 912-918. 10.1056/NEJM199703273361303CrossRefPubMed Bernard GR, Wheeler AP, Russell JA, Schein R, Summer WR, Steinberg KP, Fulkerson WJ, Wright PE, Christman BW, Dupont WD, Higgins SB, Swindell BB: The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med 1997, 336: 912-918. 10.1056/NEJM199703273361303CrossRefPubMed
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Zurück zum Zitat Amer M, Bead VR, Bathon J, Blumenthal RS, Edwards DN: Use of nonsteroidal anti-inflammatory drugs in patients with cardiovascular disease: a cautionary tale. Cardiol Rev 2010, 18: 204-212. 10.1097/CRD.0b013e3181ce1521CrossRefPubMed Amer M, Bead VR, Bathon J, Blumenthal RS, Edwards DN: Use of nonsteroidal anti-inflammatory drugs in patients with cardiovascular disease: a cautionary tale. Cardiol Rev 2010, 18: 204-212. 10.1097/CRD.0b013e3181ce1521CrossRefPubMed
Metadaten
Titel
Hot times in the intensive care unit
verfasst von
Edward Abraham
Publikationsdatum
01.08.2010
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 4/2010
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9092

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