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Pediatric Nephrology
Erschienen in: Pediatric Nephrology 9/2011

01.09.2011 | Review

Hox genes and kidney development

verfasst von: Deneen M. Wellik

Erschienen in: Pediatric Nephrology | Ausgabe 9/2011

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Abstract

The adult mammalian kidney is generated by the differentiation and integration of several distinct cell types, including the nephrogenic mesenchyme, ureteric epithelium, stromal and endothelial cells. How and where these cell types are generated and what signals lead to their differentiation and integration into a functional organ system is a main focus of current studies. Herein, we review the formation of distinct cell types within the adult mammalian kidney; what is understood regarding their origin and the signaling pathways that lead to their formation and integration; morphogenetic changes the metanephric kidney undergoes during development; and what is known regarding the role of Hox genes in these processes.
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Metadaten
Titel
Hox genes and kidney development
verfasst von
Deneen M. Wellik
Publikationsdatum
01.09.2011
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Nephrology / Ausgabe 9/2011
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-011-1902-1

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