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Medical Microbiology and Immunology

Erschienen in:

01.06.2008 | Review

Human cytomegalovirus infection and antiviral immunity in septic patients without canonical immunosuppression

verfasst von: Lutz von Müller, Thomas Mertens

Erschienen in: Medical Microbiology and Immunology | Ausgabe 2/2008

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Abstract

The human cytomegalovirus (HCMV) is a relevant pathogen in patients with immunosuppressive therapy; however, reactivation and subsequent recurrence occurs also in individuals without canonical immunosuppression as e.g., in patients with septic shock. Analyzing the impact of NK- and T-cell immunity on the natural course of HCMV infection in patients with septic shock, it became clear that the presence of HCMV reactive T-helper cells did not prevent the development of reactivation but, the control of active infection was achieved mostly by specific T-cells. NK-cells seemed to be dispensable for clearance of active infection in this patient group with long-lasting NK-cell anergy.

Stagno S, Britt W (2006) Cytomegalovirus infections. In: Remington JS, Klein JO, Wilson CB, Baker CJ (eds) Infectious diseases of the fetus and newborn infant, 6th edn. Elsevier Saunders, Philadelphia, pp 739–781CrossRef

Griffiths PD (2002) Tomorrow’s challenges for herpesvirus management: potential applications of valacyclovir. J Infect Dis 186(Suppl 1):S131–S137PubMedCrossRef

Ljungman P, Griffiths P, Paya C (2002) Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 34:1094–1097PubMedCrossRef

Sinclair J, Sissons P (2006) Latency and reactivation of human cytomegalovirus. J Gen Virol 87:1763–1779PubMedCrossRef

Hummel M, Abecassis MM (2002) A model for reactivation of CMV from latency. J Clin Virol 25(Suppl 2):S123–S136PubMedCrossRef

Simon CO, Seckert CK, Dreis D, Reddehase MJ, Grzimek NK (2005) Role for tumor necrosis factor alpha in murine cytomegalovirus transcriptional reactivation in latently infected lungs. J Virol 79:326–340PubMedPubMedCentralCrossRef

Boeckh M, Boivin G (1998) Quantitation of cytomegalovirus: methodologic aspects and clinical applications. Clin Microbiol Rev 11:533–554PubMedPubMedCentralCrossRef

von Müller L, Klemm A, Weiss M, Schneider M, Suger-Wiedeck H, Durmus N, Hampl W, Mertens T (2006) Active cytomegalovirus infection in patients with septic shock. Emerg Infect Dis 12:1517–1522CrossRef

Heininger A, Jahn G, Engel C, Notheisen T, Unertl K, Hamprecht K (2001) Human cytomegalovirus infections in nonimmunosuppressed critically ill patients. Crit Care Med 29:541–547PubMedCrossRef

10.

Kutza AST, Muhl E, Hackstein H, Kirchner H, Bein G (1998) High incidence of active cytomegalovirus infection among septic patients. Clin Infect Dis 26:1076–1082PubMedCrossRef

11.

Limaye AP, Kirby KA, Rubenfeld GD, Huang ML, Santo TK, Corey L, Boeckh M (2007) Association of cytomegalovirus (CMV) viral load with intensive care unit and hospital length of stay in critically-ill immunocompetent patients. Abstract #406, American Thoracic Society international Conference

12.

Mocarski ES, Shenk T, Pass RF (2007) Cytomegalovirus. In: Knipe DM, Howley PM (eds) Fields virology, 5th edn. Lippincott-Raven, Philadelphia, pp 2701–2772

13.

von Müller L, Klemm A, Durmus N, Weiss M, Suger-Wiedeck H, Schneider M, Hampl W, Mertens T (2007) Cellular immunity and active human cytomegalovirus infection in patients with septic shock. J Infect Dis 196:1288–1295CrossRef

14.

Frascaroli G, Varani S, Mastroianni A, Britton S, Gibellini D, Rossini G, Landini MP, Soderberg-Naucler C (2006) Dendritic cell function in cytomegalovirus-infected patients with mononucleosis. J Leukoc Biol 79:932–940PubMedCrossRef

15.

Ljungman P, Reusser P, de la CR, Einsele H, Engelhard D, Ribaud P, Ward K (2004) Management of CMV infections: recommendations from the infectious diseases working party of the EBMT. Bone Marrow Transplant 33:1075–1081PubMedCrossRef

16.

Barrios Y, Knor S, Lantto J, Mach M, Ohlin M (2007) Clonal repertoire diversification of a neutralizing cytomegalovirus glycoprotein B-specific antibody results in variants with diverse anti-viral properties. Mol Immunol 44:680–690PubMedCrossRef

17.

Nigro G, Adler SP, La TR, Best AM (2005) Passive immunization during pregnancy for congenital cytomegalovirus infection. N Engl J Med 353:1350–1362PubMedCrossRef

18.

Klenovsek K, Weisel F, Schneider A, Appelt U, Jonjic S, Messerle M, Bradel-Tretheway B, Winkler TH, Mach M (2007) Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells. Blood 110:3472–3479PubMedCrossRef

19.

Reddehase MJ, Jonjic S, Weiland F, Mutter W, Koszinowski UH (1988) Adoptive immunotherapy of murine cytomegalovirus adrenalitis in the immunocompromised host: CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors. J Virol 62:1061–1065PubMedPubMedCentralCrossRef

20.

Hertenstein B, Hampl W, Bunjes D, Wiesneth M, Duncker C, Koszinowski U, Heimpel H, Arnold R, Mertens Th (1995) In vivo/ex vivo T cell depletion for GVHD prophylaxis influences onset and course of active cytomegalovirus infection and disease after BMT. Bone Marrow Transplant 15:387–393PubMed

21.

Cerboni C, Mousavi-Jazi M, Linde A, Söderström K, Brytting M, Wahren B, Kärre K, Carbone E (2000) Human cytomegalovirus strain-dependent changes in NK cell recognition of infected fibroblasts. J Immunol 164:4775–4782PubMedCrossRef

22.

Reddehase MJ, Balthesen M, Rapp M, Jonjic S, Pavic I, Koszinowski UH (1994) The conditions of primary infection define the load of latent viral genome in organs and the risk of recurrent cytomegalovirus disease. J Exp Med 179:185–193PubMedCrossRef

23.

Slobedman B, Mocarski ES (1999) Quantitative analysis of latent human cytomegalovirus. J Virol 73:4806–4812PubMedPubMedCentralCrossRef

24.

Steffens H-P, Kurz S, Holtappels R, Reddehase MJ (1998) Preemptive CD8 T-cell immunotherapy of acute cytomegalovirus infection prevents lethal disease, limits the burden of latent viral genomes, and reduces the risk of virus recurrence. J Virol 72:1797–1804PubMedPubMedCentralCrossRef

25.

Hummel M, Zhang Z, Yan S, DePlaen I, Golia P, Varghese T, Thomas G, Abecassis MI (2001) Allogeneic transplantation induces expression of cytomegalovirus immediate-early genes in vivo: a model for reactivation from latency. J Virol 75:4814–4822PubMedPubMedCentralCrossRef

26.

Cook CH, Zhang Y, McGuinness BJ, Lahm MC, Sedmak DD, Ferguson RM (2002) Intra-abdominal bacterial infection reactivates latent pulmonary cytomegalovirus in immunocompetent mice. J Infect Dis 185:1395–1400PubMedCrossRef

27.

Cook CH, Trgovcich J, Zimmerman PD, Zhang Y, Sedmak DD (2006) Lipopolysaccharide, tumor necrosis factor alpha, or interleukin-1beta triggers reactivation of latent cytomegalovirus in immunocompetent mice. J Virol 80:9151–9158PubMedPubMedCentralCrossRef

28.

von Müller L, Schliep C, Storck M, Hampl W, Schmid T, Abendroth D, Mertens T (2006) Severe graft rejection, increased immunosuppression, and active CMV infection in renal transplantation. J Med Virol 78:394–399CrossRef

29.

Reeves MB, MacAry PA, Lehner PJ, Sissons JG, Sinclair JH (2005) Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers. Proc Natl Acad Sci USA 102:4140–4145PubMedPubMedCentralCrossRef

30.

Reeves MB, Coleman H, Chadderton J, Goddard M, Sissons JG, Sinclair JH (2004) Vascular endothelial and smooth muscle cells are unlikely to be major sites of latency of human cytomegalovirus in vivo. J Gen Virol 85:3337–3341PubMedCrossRef

31.

Mocarski ES (2002) Immunomodulation by cytomegaloviruses: manipulative strategies beyond evasion. Trends Microbiol 10:332–339PubMedCrossRef

32.

Soderberg-Naucler C, Fish KN, Nelson JA (1997) Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors. Cell 91:119–126PubMedCrossRef

33.

Rennekampff HO, Hamprecht K (2006) Cytomegalovirus infection in burns: a review. J Med Microbiol 55:483–487PubMedCrossRef

34.

Sester M, Gartner BC, Sester U, Girndt M, Mueller-Lantzsch N, Kohler H (2003) Is the cytomegalovirus serologic status always accurate? a comparative analysis of humoral and cellular immunity. Transplantation 76:1229–1230PubMedCrossRef

35.

von Müller L, Hinz J, Bommer M, Hampl W, Kluwick S, Wiedmann M, Bunjes D, Mertens T (2007) CMV monitoring using blood cells and plasma: a comparison of apples with oranges? Bone Marrow Transplant 39:353–357CrossRef

36.

Emery VC, Sabin CA, Cope AV, Gor D, Hassan-Walker AF, Griffiths PD (2000) Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation. Lancet 355:2032–2036PubMedCrossRef

37.

Einsele H, Roosnek E, Rufer N, Sinzger C, Riegler S, Loffler J, Grigoleit U, Moris A, Rammensee HG, Kanz L et al (2002) Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood 99:3916–3922PubMedCrossRef

38.

Fishman JA (2007) Infection in solid-organ transplant recipients. N Engl J Med 357:2601–2614PubMedCrossRef

39.

Rauser G, Einsele H, Sinzger C, Wernet D, Kuntz G, Assenmacher M, Campbell JD, Topp MS (2004) Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants. Blood 103:3565–3572PubMedCrossRef

40.

Riddell SR, Watanabe KS, Goodrich JM, Li CR, Agha ME, Greenberg PD (1992) Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 257:238–241PubMedCrossRef

41.

Mocarski ES (2004) Immune escape and exploitation strategies of cytomegaloviruses: impact on and imitation of the major histocompatibility system. Cell Microbiol 6:707–717PubMedCrossRef

42.

French AR, Yokoyama WM (2003) Natural killer cells and viral infections. Curr Opin Immunol 15:45–51PubMedCrossRef

43.

Puente J, Carvajal T, Parra S, Miranda D, Sepulveda C, Wolf ME, Mosnaim AD (1993) In vitro studies of natural killer cell activity in septic shock patients. Response to a challenge with alpha-interferon and interleukin-2. Int J Clin Pharmacol Ther Toxicol 31:271–275PubMed

44.

Vredevoe DL, Widawski M, Fonarow GC, Hamilton M, Martinez-Maza O, Gage JR (2004) Interleukin-6 (IL-6) expression and natural killer (NK) cell dysfunction and anergy in heart failure. Am J Cardiol 93:1007–1011PubMedCrossRef

45.

Waner JL, Budnick JE (1977) Blastogenic response of human lymphocytes to human cytomegalovirus. Clin Exp Immunol 30:44–49PubMedPubMedCentral

46.

Sester M, Sester U, Gärtner B, Heine G, Girndt M, Mueller-Lantzsch N, Meyerhans A, Kohler H (2001) Levels of virus-specific CD4 T cells correlate with cytomegalovirus control and predict virus-induced disease after renal transplantation. Transplantation 71:1287–1294PubMedCrossRef

47.

Llewelyn M, Cohen J (2002) Superantigens: microbial agents that corrupt immunity. Lancet Infect Dis 2:156–162PubMedCrossRef

48.

Ljungman P, De Bock R, Cordonnier C, Einsele H, Engelhard D, Grundy J, Locasciulli A, Reusser P, Ribaud P (1993) Practices for cytomegalovirus diagnosis, prophylaxis and treatment in allogeneic bone marrow transplant recipients: a report from the working party for infectious diseases of the EBMT. Bone Marrow Transplant 12:399–403PubMed

49.

Barry SM, Johnson MA, Janossy G (2000) Cytopathology or immunopathology? The puzzle of cytomegalovirus pneumonitis revisited. Bone Marrow Transplant 26:591–597PubMedPubMedCentralCrossRef

50.

Fishman JA, Emery V, Freeman R, Pascual M, Rostaing L, Schlitt HJ, Sgarabotto D, Torre-Cisneros J, Uknis ME (2007) Cytomegalovirus in transplantation—challenging the status quo. Clin Transplant 21:149–158PubMedCrossRef

51.

Lowance D, Neumayer H-H, Legendre CM, Squifflet J-P, Kovarik J, Brennan PJ, Norman D, Mendez R, Keating MR, Coggon GL et al (1999) Valacyclovir for the prevention of cytomegalovirus disease after renal transplantation. N Engl J Med 340:1462–1470PubMedCrossRef

52.

Reinhardt B, Mertens Th, Mayr U, Frank H, Lüske A, Waltenberger J (2004) HCMV-infection leads to enhanced PDGF responsiveness of vascular smooth muscle cells. Cardiovasc Res

53.

Cook CH, Zhang Y, Sedmak DD, Martin LC, Jewell S, Ferguson RM (2006) Pulmonary cytomegalovirus reactivation causes pathology in immunocompetent mice. Crit Care Med 34:842–849PubMedPubMedCentralCrossRef

54.

Docke WD, Prosch S, Fietze E, Kimel V, Zuckermann H, Klug C, Syrbe U, Kruger DH, von Baehr R, Volk HD (1994) Cytomegalovirus reactivation and tumour necrosis factor. Lancet 343:268–269PubMedCrossRef

55.

Simon CO, Holtappels R, Tervo HM, Bohm V, Daubner T, Oehrlein-Karpi SA, Kuhnapfel B, Renzaho A, Strand D, Podlech J et al (2006) CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivation. J Virol 80:10436–10456PubMedPubMedCentralCrossRef

Titel: Human cytomegalovirus infection and antiviral immunity in septic patients without canonical immunosuppression
verfasst von: Lutz von Müller
Thomas Mertens
Publikationsdatum: 01.06.2008
Verlag: Springer Berlin Heidelberg
Erschienen in: Medical Microbiology and Immunology / Ausgabe 2/2008
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-008-0087-0

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