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Journal of Gastrointestinal Surgery

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01.04.2011 | Review Article

Humans, Mice, and Mechanisms of Intestinal Atresias: A Window into Understanding Early Intestinal Development

verfasst von: Peter F. Nichol, Amy Reeder, Robert Botham

Erschienen in: Journal of Gastrointestinal Surgery | Ausgabe 4/2011

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Abstract

Introduction

Intestinal atresias have long been hypothesized to result from either failure of recanalization of the intestinal lumen or in utero vascular accidents. Recent work in animal models is now calling for a reassessment of these widely held paradigms.

Purpose

In this review, we will examine the data that led to the original hypotheses and then evaluate more recent work challenging these hypotheses. Furthermore, we will discuss how defining the mechanism of atresia formation in animal models may provide insight into early intestinal development and the mechanism of lengthwise intestinal growth.

Conclusion

Such insight will be critical in developing regenerative therapies for patients with intestinal failure.

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Titel: Humans, Mice, and Mechanisms of Intestinal Atresias: A Window into Understanding Early Intestinal Development
verfasst von: Peter F. Nichol
Amy Reeder
Robert Botham
Publikationsdatum: 01.04.2011
Verlag: Springer-Verlag
Erschienen in: Journal of Gastrointestinal Surgery / Ausgabe 4/2011
Print ISSN: 1091-255X
Elektronische ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-010-1400-y

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Abstract

Introduction

Purpose

Conclusion

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