Erschienen in:
19.06.2019 | Editorial Commentary
Hypothyroxinemia in Preterm Neonates: Not Always Hypothyroidism
verfasst von:
Vijayalakshmi Bhatia
Erschienen in:
Indian Journal of Pediatrics
|
Ausgabe 8/2019
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Excerpt
Thyroid physiology in preterm neonates is characterized by differences from that in the term counterpart. Challenges to interpretation of the results of newborn screening (NBS) for congenital hypothyroidism (CH) include: (a) low serum thyroxine (T4), which may mislead one to a diagnosis of CH, in T4 based NBS, and (b) falsely low TSH (or delayed rise of TSH, due to immaturity of the pituitary gland) which may lead to missed diagnosis of true CH in TSH based NBS. Besides the setting of NBS, thyroid function tests are performed for a variety of indications in the neonate; these results too may be subject to wrong interpretation. …