Skip to main content
Erschienen in: HSS Journal ® 1/2015

01.02.2015 | Cervical Spine Symposium

Iatrogenic Contributions to Cervical Adjacent Segment Pathology

Review Article

verfasst von: Haruki Ueda, MD, Russel C. Huang, MD, Darren R. Lebl, MD

Erschienen in: HSS Journal ® | Ausgabe 1/2015

Einloggen, um Zugang zu erhalten

Abstract

Background

Anterior cervical discectomy and fusion (ACDF) is widely accepted as a predictably excellent procedure. On the other hand, adjacent level pathology following ACDF is a well-known phenomenon which undercuts surgical outcome. However, the extent to which ACDF accelerates this phenomenon in the naturally degenerating cervical spine is still to be understood.

Questions/Purposes

To summarize the current evidence concerning adjacent segment pathology in the light of biomechanics, natural history, postoperative course, and comparison between ACDF and total disc replacement (TDR).

Methods

This is a study of published articles. Articles were searched by the topic of adjacent disc pathology in cervical spine through Google Scholar and Pubmed. After review, 37 published articles were deemed suitable for the subject of this study.

Results

Biomechanical and clinical data strongly suggest that ASP is a presentation of the iatrogenically accelerated natural aging process of cervical spine. However, power study analysis with assumption showed that current RCTs are unlikely to prove this suggestion.

Conclusion

Available data suggests that iatrogenic factors play a significant role in adjacent segment pathology following ACDF.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Anderson P, Sasso R, Metcalf N, et al. Reoperation rates for cervical arthroplasty vs. arthrodesis. Spine J. 2005; 5: 76 s-77 s.CrossRef Anderson P, Sasso R, Metcalf N, et al. Reoperation rates for cervical arthroplasty vs. arthrodesis. Spine J. 2005; 5: 76 s-77 s.CrossRef
2.
Zurück zum Zitat Anderson PA, Sasso RC, Riew KD. Comparison of adverse events between the Bryan artificial cervical disc and anterior cervical arthrodesis. Spine. 2008; 33: 1305-12.CrossRefPubMed Anderson PA, Sasso RC, Riew KD. Comparison of adverse events between the Bryan artificial cervical disc and anterior cervical arthrodesis. Spine. 2008; 33: 1305-12.CrossRefPubMed
3.
Zurück zum Zitat Anderson PA, Andersson GBJ, Arnold PM, et al. Terminology. Spine. 2012; 37(22S): 8-9.CrossRef Anderson PA, Andersson GBJ, Arnold PM, et al. Terminology. Spine. 2012; 37(22S): 8-9.CrossRef
4.
Zurück zum Zitat Auerbach J, Anakwenze O, Milby A, et al. Segmental contribution toward total cervical range of motion: a comparison of cervical disc arthroplasty and fusion. Spine. 2011; 36: E1593-9.CrossRefPubMed Auerbach J, Anakwenze O, Milby A, et al. Segmental contribution toward total cervical range of motion: a comparison of cervical disc arthroplasty and fusion. Spine. 2011; 36: E1593-9.CrossRefPubMed
5.
Zurück zum Zitat Baba H, Furusawa N, Imura S, et al. Late radiographic findings after anterior cervical fusion for spondylotic myeloradiculopathy. Spine. 1993; 18: 2167-73.CrossRefPubMed Baba H, Furusawa N, Imura S, et al. Late radiographic findings after anterior cervical fusion for spondylotic myeloradiculopathy. Spine. 1993; 18: 2167-73.CrossRefPubMed
6.
Zurück zum Zitat Burkus JK, Haid RW, Traynelis VC, Mummaneni PV. Long-term clinical and radiographic outcomes of cervical disc replacement with the prestige disc: results from a prospective randomized controlled clinical trial. J Neurosurg Spine. 2010; 13: 308-18.CrossRefPubMed Burkus JK, Haid RW, Traynelis VC, Mummaneni PV. Long-term clinical and radiographic outcomes of cervical disc replacement with the prestige disc: results from a prospective randomized controlled clinical trial. J Neurosurg Spine. 2010; 13: 308-18.CrossRefPubMed
7.
Zurück zum Zitat Carrier CS, Bono CM, Lebl DR. Evidence-based analysis of adjacent segment degeneration and disease after ACDF: a systematic review. Spine J 2013 Carrier CS, Bono CM, Lebl DR. Evidence-based analysis of adjacent segment degeneration and disease after ACDF: a systematic review. Spine J 2013
8.
Zurück zum Zitat Delamarter RB, Zigler J. Five-year reoperation rates, cervical total disc replacement versus fusion, results of a prospective randomized clinical trial. Spine. 2013; 38(9): 711-717.CrossRefPubMed Delamarter RB, Zigler J. Five-year reoperation rates, cervical total disc replacement versus fusion, results of a prospective randomized clinical trial. Spine. 2013; 38(9): 711-717.CrossRefPubMed
9.
Zurück zum Zitat Dmitriev AE, Cunningham BW, Hu N, et al. Adjacent level intradis- cal pressure and segmental kinematics following a cervical total disc arthroplasty: an in vitro human cadaveric model. Spine. 2005; 30: 1165-72.CrossRefPubMed Dmitriev AE, Cunningham BW, Hu N, et al. Adjacent level intradis- cal pressure and segmental kinematics following a cervical total disc arthroplasty: an in vitro human cadaveric model. Spine. 2005; 30: 1165-72.CrossRefPubMed
10.
Zurück zum Zitat Eck JC, Humphreys SC, Lim TH, et al. Biomechanical study on the effect of cervical spine fusion on adjacent-level intradiscal pressure and segmental motion. Spine. 2002; 27: 2431-4.CrossRefPubMed Eck JC, Humphreys SC, Lim TH, et al. Biomechanical study on the effect of cervical spine fusion on adjacent-level intradiscal pressure and segmental motion. Spine. 2002; 27: 2431-4.CrossRefPubMed
11.
Zurück zum Zitat Goffin J, Geusens E, Vantomme N, et al. Long-term follow-up after interbody fusion of the cervical spine. J Spinal Disord Tech. 2004; 17: 79-85.CrossRefPubMed Goffin J, Geusens E, Vantomme N, et al. Long-term follow-up after interbody fusion of the cervical spine. J Spinal Disord Tech. 2004; 17: 79-85.CrossRefPubMed
12.
Zurück zum Zitat Gore DR. Roentgenographic findings in the cervical spine in asymptomatic persons; a ten-year follow-up. Spine. 2001; 26(22): 2463-2466.CrossRefPubMed Gore DR. Roentgenographic findings in the cervical spine in asymptomatic persons; a ten-year follow-up. Spine. 2001; 26(22): 2463-2466.CrossRefPubMed
13.
Zurück zum Zitat Gore DR, Sepic SB. Anterior cervical fusion for degenerated or pro- truded discs: a review of one hundred forty-six patients. Spine. 1984; 9(7): 667-71.CrossRefPubMed Gore DR, Sepic SB. Anterior cervical fusion for degenerated or pro- truded discs: a review of one hundred forty-six patients. Spine. 1984; 9(7): 667-71.CrossRefPubMed
14.
Zurück zum Zitat Gore DR, Gardner GM, Sepic SB, et al. Roentgenographic findings following anterior cervical fusion. Skeletal Radiol. 1986; 15: 556-559.CrossRefPubMed Gore DR, Gardner GM, Sepic SB, et al. Roentgenographic findings following anterior cervical fusion. Skeletal Radiol. 1986; 15: 556-559.CrossRefPubMed
15.
Zurück zum Zitat Grunhagen T, Shirazi-Adl A, Fairbank JCT, et al. Intervertebral disk nutrition: a review of factors influencing concentrations of nutrients and metabolites. Orthop Clin N Am. 2011; 42: 465-477.CrossRef Grunhagen T, Shirazi-Adl A, Fairbank JCT, et al. Intervertebral disk nutrition: a review of factors influencing concentrations of nutrients and metabolites. Orthop Clin N Am. 2011; 42: 465-477.CrossRef
16.
Zurück zum Zitat Helgeson MD, Bevevino AJ, Hilibrand AS. Update on the evidence for adjacent segment degeneration and disease. Spine J. 2013; 13: 342-351.CrossRefPubMed Helgeson MD, Bevevino AJ, Hilibrand AS. Update on the evidence for adjacent segment degeneration and disease. Spine J. 2013; 13: 342-351.CrossRefPubMed
17.
Zurück zum Zitat Hilibrand AS, Robbins M. Adjacent segment degeneration and adjacent segment disease: the consequences of spinal fusion? Spine J. 2004; 4: 190s-194s.CrossRefPubMed Hilibrand AS, Robbins M. Adjacent segment degeneration and adjacent segment disease: the consequences of spinal fusion? Spine J. 2004; 4: 190s-194s.CrossRefPubMed
18.
Zurück zum Zitat Hilibrand AS, Carlson GD, Palumbo MA, et al. Radiculopathy and myelopathy at segments adjacent to the site of a previous anterior cervical arthrodesis. J Bone Joint Surg Am. 1999; 81: 519-28.PubMed Hilibrand AS, Carlson GD, Palumbo MA, et al. Radiculopathy and myelopathy at segments adjacent to the site of a previous anterior cervical arthrodesis. J Bone Joint Surg Am. 1999; 81: 519-28.PubMed
19.
Zurück zum Zitat Ishihara H, Kanamori M, Kawaguchi Y, et al. Adjacent segment disease after anterior cervical interbody fusion. Spine J. 2004; 4: 624-8.CrossRefPubMed Ishihara H, Kanamori M, Kawaguchi Y, et al. Adjacent segment disease after anterior cervical interbody fusion. Spine J. 2004; 4: 624-8.CrossRefPubMed
20.
Zurück zum Zitat Jawahar A, Cavanaugh DA, Kerr EJ 3rd, et al. Total disc arthroplasty does not affect the incidence of adjacent segment degeneration in cervical spine: results of 93 patients in three prospective randomized clinical trials. Spine J. 2010; 10: 1043-8.CrossRefPubMed Jawahar A, Cavanaugh DA, Kerr EJ 3rd, et al. Total disc arthroplasty does not affect the incidence of adjacent segment degeneration in cervical spine: results of 93 patients in three prospective randomized clinical trials. Spine J. 2010; 10: 1043-8.CrossRefPubMed
21.
Zurück zum Zitat Kelly MP, Mok JM, Frisch RF, Tay BK. Adjacent segment motion after anterior cervical discectomy and fusion versus prodisc-c cervical total disk arthroplasty: analysis from a randomized, controlled trial. Spine. 2011; 36: 1171-9.CrossRefPubMed Kelly MP, Mok JM, Frisch RF, Tay BK. Adjacent segment motion after anterior cervical discectomy and fusion versus prodisc-c cervical total disk arthroplasty: analysis from a randomized, controlled trial. Spine. 2011; 36: 1171-9.CrossRefPubMed
22.
Zurück zum Zitat Lee MJ, Dettori JR, Standaert CJ, et al. The natural history of degeneration of the lumbar and cervical spines: a systematic review. Spine. 2012; 37(22S): S18-S30.CrossRefPubMed Lee MJ, Dettori JR, Standaert CJ, et al. The natural history of degeneration of the lumbar and cervical spines: a systematic review. Spine. 2012; 37(22S): S18-S30.CrossRefPubMed
23.
Zurück zum Zitat Maldonado CV, Paz RD, Martin CB. Adjacent-level degeneration after cervical disc arthroplasty versus fusion. Eur Spine J. 2011; 20(3 Suppl): 403-7.CrossRefPubMedCentralPubMed Maldonado CV, Paz RD, Martin CB. Adjacent-level degeneration after cervical disc arthroplasty versus fusion. Eur Spine J. 2011; 20(3 Suppl): 403-7.CrossRefPubMedCentralPubMed
24.
Zurück zum Zitat Matsumoto M, Okada E, Ichihara D, et al. Anterior cervical decompression and fusion accelerates adjacent segment degeneration: comparison with asymptomatic volunteers in a ten-year magnetic resonance imaging follow-up study. Spine. 2010; 35: 36-43.CrossRefPubMed Matsumoto M, Okada E, Ichihara D, et al. Anterior cervical decompression and fusion accelerates adjacent segment degeneration: comparison with asymptomatic volunteers in a ten-year magnetic resonance imaging follow-up study. Spine. 2010; 35: 36-43.CrossRefPubMed
25.
Zurück zum Zitat Mummaneni PV, Burkus JK, Haid RW, et al. Clinical and radiographic analysis of cervical disc arthroplasty compared with allograft fusion: a randomized controlled clinical trial. J Neurosurg Spine. 2007; 6: 198-9.CrossRefPubMed Mummaneni PV, Burkus JK, Haid RW, et al. Clinical and radiographic analysis of cervical disc arthroplasty compared with allograft fusion: a randomized controlled clinical trial. J Neurosurg Spine. 2007; 6: 198-9.CrossRefPubMed
26.
Zurück zum Zitat Okada E, Matsumoto M, Fujiwara H, et al. Disc degeneration of cervical spine on MRI in patients with lumbar disc herniation: comparison study with asymptomatic volunteers. Eur Spine J. 2011; 20(4): 585-591.CrossRefPubMedCentralPubMed Okada E, Matsumoto M, Fujiwara H, et al. Disc degeneration of cervical spine on MRI in patients with lumbar disc herniation: comparison study with asymptomatic volunteers. Eur Spine J. 2011; 20(4): 585-591.CrossRefPubMedCentralPubMed
27.
Zurück zum Zitat Park JB, Cho YS, Riew KD. Development of adjacent-level ossification in patients with an anterior cervical plate. J Bone Joint Surg Am. 2005; 87: 558-63.PubMed Park JB, Cho YS, Riew KD. Development of adjacent-level ossification in patients with an anterior cervical plate. J Bone Joint Surg Am. 2005; 87: 558-63.PubMed
28.
Zurück zum Zitat Robertson JT, Papadopoulos SM, Traynelis VC. Assessment of adjacent-segment disease in patients treated with cervical fusion or arthroplasty: a prospective 2-year study. J Neurosurg Spine. 2005; 3: 417-23.CrossRefPubMed Robertson JT, Papadopoulos SM, Traynelis VC. Assessment of adjacent-segment disease in patients treated with cervical fusion or arthroplasty: a prospective 2-year study. J Neurosurg Spine. 2005; 3: 417-23.CrossRefPubMed
29.
Zurück zum Zitat Robinson RA, Smith GW. Anterolateral cervical disc removal and interbody fusion for cervical disc syndrome. (Abstract.) Bull. Johns Hopkins Hosp. 1955; 96: 223-224. Robinson RA, Smith GW. Anterolateral cervical disc removal and interbody fusion for cervical disc syndrome. (Abstract.) Bull. Johns Hopkins Hosp. 1955; 96: 223-224.
30.
Zurück zum Zitat Sasso RC, Smucker JD, Hacker RJ, et al. Artificial disc versus fusion. Spine. 2007; 26(32): 2933-2940.CrossRef Sasso RC, Smucker JD, Hacker RJ, et al. Artificial disc versus fusion. Spine. 2007; 26(32): 2933-2940.CrossRef
31.
Zurück zum Zitat Sasso R, Anderson P, Riew K, et al. Results of cervical arthroplasty compared with anterior discectomy and fusion: four-year clinical outcomes in a prospective, randomized, controlled trial. J Bone Joint Surg Am. 2011; 93: 1684-92.CrossRefPubMed Sasso R, Anderson P, Riew K, et al. Results of cervical arthroplasty compared with anterior discectomy and fusion: four-year clinical outcomes in a prospective, randomized, controlled trial. J Bone Joint Surg Am. 2011; 93: 1684-92.CrossRefPubMed
32.
Zurück zum Zitat Satyajit M, Girardi F, Sama A, et al. National trends in anterior cervical fusion procedures. Spine. 2010; 35(15): 1454-1459. Satyajit M, Girardi F, Sama A, et al. National trends in anterior cervical fusion procedures. Spine. 2010; 35(15): 1454-1459.
33.
Zurück zum Zitat Smith GW, Robinson RA. The treatment of certain cervical-spine disorders by anterior removal of the intervertebral disc and interbody fusion. J Bone Jt Surg. 1958; 40-A: 607-624. Smith GW, Robinson RA. The treatment of certain cervical-spine disorders by anterior removal of the intervertebral disc and interbody fusion. J Bone Jt Surg. 1958; 40-A: 607-624.
34.
Zurück zum Zitat Wilder FV, Hall BJ, Barrett JP. Smoking and osteoarthritis: is there an association? the clearwater osteoarthritis study. Osteoarthritis Cartilage 2003;11:29. Wilder FV, Hall BJ, Barrett JP. Smoking and osteoarthritis: is there an association? the clearwater osteoarthritis study. Osteoarthritis Cartilage 2003;11:29.
35.
Zurück zum Zitat Wilder FV, Fahlman L, Donnelly R. Radiographic cervical spine osteoarthritis progression rates: a longitudinal assessment. Rheu- matol Int 2011;31:45 Wilder FV, Fahlman L, Donnelly R. Radiographic cervical spine osteoarthritis progression rates: a longitudinal assessment. Rheu- matol Int 2011;31:45
36.
Zurück zum Zitat Yue WM, Brodner W, Highland TR. Long-term results after anterior cervical discectomy and fusion with allograft and plating: a 5- to 11-year radiologic and clinical follow-up study. Spine. 2005; 30: 2138-44.CrossRefPubMed Yue WM, Brodner W, Highland TR. Long-term results after anterior cervical discectomy and fusion with allograft and plating: a 5- to 11-year radiologic and clinical follow-up study. Spine. 2005; 30: 2138-44.CrossRefPubMed
Metadaten
Titel
Iatrogenic Contributions to Cervical Adjacent Segment Pathology
Review Article
verfasst von
Haruki Ueda, MD
Russel C. Huang, MD
Darren R. Lebl, MD
Publikationsdatum
01.02.2015
Verlag
Springer US
Erschienen in
HSS Journal ® / Ausgabe 1/2015
Print ISSN: 1556-3316
Elektronische ISSN: 1556-3324
DOI
https://doi.org/10.1007/s11420-014-9409-5

Weitere Artikel der Ausgabe 1/2015

HSS Journal ® 1/2015 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

TEP mit Roboterhilfe führt nicht zu größerer Zufriedenheit

15.05.2024 Knie-TEP Nachrichten

Der Einsatz von Operationsrobotern für den Einbau von Totalendoprothesen des Kniegelenks hat die Präzision der Eingriffe erhöht. Für die postoperative Zufriedenheit der Patienten scheint das aber unerheblich zu sein, wie eine Studie zeigt.

Lever-Sign-Test hilft beim Verdacht auf Kreuzbandriss

15.05.2024 Vordere Kreuzbandruptur Nachrichten

Mit dem Hebelzeichen-Test lässt sich offenbar recht zuverlässig feststellen, ob ein vorderes Kreuzband gerissen ist. In einer Metaanalyse war die Vorhersagekraft vor allem bei positivem Testergebnis hoch.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Klinik aktuell Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Aquatherapie bei Fibromyalgie wirksamer als Trockenübungen

03.05.2024 Fibromyalgiesyndrom Nachrichten

Bewegungs-, Dehnungs- und Entspannungsübungen im Wasser lindern die Beschwerden von Patientinnen mit Fibromyalgie besser als das Üben auf trockenem Land. Das geht aus einer spanisch-brasilianischen Vergleichsstudie hervor.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.