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01.05.2010 | Original Article

Identification and characterization of novel hepatitis B virus subgenotype C10 in Nusa Tenggara, Indonesia

verfasst von: Mulyanto, Sulaiman Ngongu Depamede, Kiely Surayah, Andreas Andhry Heru Tjahyono, Jirintai, Shigeo Nagashima, Masaharu Takahashi, Hiroaki Okamoto

Erschienen in: Archives of Virology | Ausgabe 5/2010

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Abstract

Six novel subgenotypes (B7, B8, C6, C8, C9, and D6) within three hepatitis B virus (HBV) genotypes (B–D) were recently identified in Indonesia. To further characterize HBV in this country, 18 HBV-viremic samples obtained from blood donors in Nusa Tenggara, Indonesia, were subjected to phylogenetic analysis of an 1.6-kb partial or full-length sequence. Thirteen HBV isolates were classified into genotype B with four distinct subgenotypes [B3 (n = 2), B5 (n = 1), B7 (n = 4), and B8 (n = 6)], followed by 4 HBV isolates of genotype C (HBV/C); the remaining one isolate was of D (D1). As for the four HBV/C isolates, one isolate segregated into subgenotype C1, and two into C2. The remaining HBV/C isolate [C0901177(NT3)] differed from reported HBV/C isolates (C1–C9) by 4.6–7.7% over the entire genome and did not show evidence of recombination with any of the known HBV genotypes/subgenotypes, justifying its conclusive assignment into a novel subgenotype (C10) within genotype C.

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Titel: Identification and characterization of novel hepatitis B virus subgenotype C10 in Nusa Tenggara, Indonesia
verfasst von: Mulyanto
Sulaiman Ngongu Depamede
Kiely Surayah
Andreas Andhry Heru Tjahyono
Jirintai
Shigeo Nagashima
Masaharu Takahashi
Hiroaki Okamoto
Publikationsdatum: 01.05.2010
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 5/2010
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-010-0628-x

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