Erschienen in:
01.10.2008 | Original Article
Identification of a new HLA-Cw*07 allele, HLA-Cw*0743, from a Chinese hematopoietic stem cell donor
verfasst von:
Haiyan Zhu, Dandan Zhao, Xiaoping Han, Jingfen Sun, Wanming Da, Li Yu, Chunji Gao
Erschienen in:
International Journal of Hematology
|
Ausgabe 3/2008
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Abstract
A new allele of the human leukocyte antigen C (HLA-C) locus was identified during routine HLA typing of a Chinese hematopoietic stem cell donor in Beijing, China. Sequence analysis of exons 2 and 3 of the HLA-C gene revealed the novel polymorphism. The closest matched allele was HLA-Cw*0710. A comparison of the two alleles showed that HLA-Cw*0743 carried a nucleotide substitution of C to A at codon 99 in exon 3, resulting in an amino acid substitution of serine to tyrosine with no obvious change in protein structure.