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01.10.2008 | Original Article

Reduced-intensity unrelated donor bone marrow transplantation for hematologic malignancies

verfasst von: Sung-Won Kim, Keitaro Matsuo, Takahiro Fukuda, Masamichi Hara, Kosei Matsue, Shuichi Taniguchi, Tetsuya Eto, Mitsune Tanimoto, Atsushi Wake, Kazuo Hatanaka, Shinji Nakao, Yoji Ishida, Mine Harada, Atae Utsunomiya, Masahiro Imamura, Yoshinobu Kanda, Kazutaka Sunami, Fumio Kawano, Yoichi Takaue, Takanori Teshima

Erschienen in: International Journal of Hematology | Ausgabe 3/2008

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Abstract

To review a current experience of unrelated bone marrow transplantation (BMT) with reduced-intensity conditioning (RIC) regimens, we conducted a nationwide survey with 77 patients (age, 25–68 years). The backbone RIC regimen was a combination of fludarabine or cladribine, busulfan or melphalan and total body irradiation at 2–4 Gy. Five patients died early, but 71 (92%) achieved initial neutrophil recovery. Thereafter, 36 patients (47%) died of therapy-related complications, 23 (30%) of whom died within day 100. Grades II–IV acute graft-versus-host disease (GVHD) occurred in 34 of the 68 evaluable patients (50%). In a multivariate analysis, a regimen containing antithymocyte globulin (ATG) was significantly associated with a decreased risk of acute GVHD (P = 0.041). Thirty-three patients are currently alive with a median follow-up of 439 days (28–2002 days), with an OS of 50% at 1 year. In conclusion, unrelated BMT with RIC regimens can be a curative treatment in a subset of patients.

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Titel: Reduced-intensity unrelated donor bone marrow transplantation for hematologic malignancies
verfasst von: Sung-Won Kim
Keitaro Matsuo
Takahiro Fukuda
Masamichi Hara
Kosei Matsue
Shuichi Taniguchi
Tetsuya Eto
Mitsune Tanimoto
Atsushi Wake
Kazuo Hatanaka
Shinji Nakao
Yoji Ishida
Mine Harada
Atae Utsunomiya
Masahiro Imamura
Yoshinobu Kanda
Kazutaka Sunami
Fumio Kawano
Yoichi Takaue
Takanori Teshima
Publikationsdatum: 01.10.2008
Verlag: Springer Japan
Erschienen in: International Journal of Hematology / Ausgabe 3/2008
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-008-0163-7

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