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Erschienen in: Forensic Toxicology 1/2013

01.01.2013 | Short Communication

Identification of N-ethyl-α-ethylphenethylamine in crystalline powder seized for suspected drug trafficking: a research chemical or a new designer drug?

verfasst von: Jaesin Lee, Sanggil Choe, Hyeyoung Choi, Sewoong Heo, Eunmi Kim, Hyunju Kim, Eunjung Bang, Heesun Chung

Erschienen in: Forensic Toxicology | Ausgabe 1/2013

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Abstract

A crystalline powder was found in an unclaimed lost article shipped from Vietnam to South Korea, and it was seized by narcotics agents as an item of suspicious trade. The chemical was suspected to be methamphetamine crystals, and was sent to the National Forensic Service for forensic identification. Elucidation of the chemical structure was carried out using gas chromatography–electron impact ionization–mass spectrometry, liquid chromatography–time-of-flight–mass spectrometry, and 1D and 2D nuclear magnetic resonance spectroscopy. The compound was identified as N-ethyl-α-ethylphenethylamine. Although the narcotic effect of this compound remains unverified, it may be classified as a phenethylamine-based designer drug on the basis of its structure. It appeared that the recipient of this article sought to abuse this chemical in the same way as amphetamines. There is a possibility that this chemical will be widely abused for recreational use in the near future.
Literatur
1.
Zurück zum Zitat Namera A, Nakamoto A, Saito T, Nagao M (2011) Colorimetric detection and chromatographic analyses of designer drugs in biological materials: a comprehensive review. Forensic Toxicol 29:1–24CrossRef Namera A, Nakamoto A, Saito T, Nagao M (2011) Colorimetric detection and chromatographic analyses of designer drugs in biological materials: a comprehensive review. Forensic Toxicol 29:1–24CrossRef
2.
Zurück zum Zitat Auwärter V, Dresen S, Weinmann W, Müller M, Pütz M, Fereirós N (2009) ‘Spice’ and other herbal blends: harmless incense or cannabinoid designer drugs? J Mass Spectrom 44:832–837PubMedCrossRef Auwärter V, Dresen S, Weinmann W, Müller M, Pütz M, Fereirós N (2009) ‘Spice’ and other herbal blends: harmless incense or cannabinoid designer drugs? J Mass Spectrom 44:832–837PubMedCrossRef
3.
Zurück zum Zitat Uchiyama N, Kawamura M, Kikura-Hanajiri R, Goda Y (2011) Identification and quantitation of two cannabimimetic phenylacetylindoles JWH-251 and JWH-250, and four cannabimimetic naphthoylidoles JWH-081, JWH-015, JWH-200, and JWH-073 as designer drugs in illegal products. Forensic Toxicol 29:25–37CrossRef Uchiyama N, Kawamura M, Kikura-Hanajiri R, Goda Y (2011) Identification and quantitation of two cannabimimetic phenylacetylindoles JWH-251 and JWH-250, and four cannabimimetic naphthoylidoles JWH-081, JWH-015, JWH-200, and JWH-073 as designer drugs in illegal products. Forensic Toxicol 29:25–37CrossRef
4.
Zurück zum Zitat 2011 Annual report of the state of the drugs problem in Europe. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Lisbon, November 2011 2011 Annual report of the state of the drugs problem in Europe. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Lisbon, November 2011
5.
Zurück zum Zitat World Drug Report (2011) United Nations Office of Drugs and Crime (UNODC). June, Vienna 2011 World Drug Report (2011) United Nations Office of Drugs and Crime (UNODC). June, Vienna 2011
6.
Zurück zum Zitat Hillebrand J, Olszewski D, Sedefov R (2010) Legal highs on the Internet. Subst Use Misuse 45:330–340PubMedCrossRef Hillebrand J, Olszewski D, Sedefov R (2010) Legal highs on the Internet. Subst Use Misuse 45:330–340PubMedCrossRef
7.
Zurück zum Zitat Zaitsu K, Katagi M, Tatsuno M, Sato T, Tsuchihasi H, Suzuki K (2011) Recently abused β-keto derivatives of 3,4-methylenedioxyphenylalkylamines: a review of their metabolisms and toxicological analysis. Forensic Toxicol 29:73–84CrossRef Zaitsu K, Katagi M, Tatsuno M, Sato T, Tsuchihasi H, Suzuki K (2011) Recently abused β-keto derivatives of 3,4-methylenedioxyphenylalkylamines: a review of their metabolisms and toxicological analysis. Forensic Toxicol 29:73–84CrossRef
8.
Zurück zum Zitat Zuba D (2012) Identification of cathinones and other active components of ‘legal highs’ by mass spectrometric methods. Trends Anal Chem 32:15–30CrossRef Zuba D (2012) Identification of cathinones and other active components of ‘legal highs’ by mass spectrometric methods. Trends Anal Chem 32:15–30CrossRef
9.
Zurück zum Zitat Coppola M, Mondola R (2012) 3,4-Methylenedioxypyrovalerone (MDPV): chemistry, pharmacology and toxicology of a new designer drug of abuse marketed online. Toxicol Lett 208:12–15PubMedCrossRef Coppola M, Mondola R (2012) 3,4-Methylenedioxypyrovalerone (MDPV): chemistry, pharmacology and toxicology of a new designer drug of abuse marketed online. Toxicol Lett 208:12–15PubMedCrossRef
10.
Zurück zum Zitat Gibbons S, Zloh M (2010) An analysis of the ‘legal high’ mephedrone. Bioorg Med Chem Lett 20:4135–4139PubMedCrossRef Gibbons S, Zloh M (2010) An analysis of the ‘legal high’ mephedrone. Bioorg Med Chem Lett 20:4135–4139PubMedCrossRef
11.
Zurück zum Zitat Maheux CR, Copeland CR, Pollard MM (2010) Characterization of three methcathinone analogs: 4-methylmethcathinone, methylone, and bk-MBDB. Microgram J 7:42–49 Maheux CR, Copeland CR, Pollard MM (2010) Characterization of three methcathinone analogs: 4-methylmethcathinone, methylone, and bk-MBDB. Microgram J 7:42–49
12.
Zurück zum Zitat Theobald DS, Maurer HH (2007) Identification of monoamine oxidase and cytochrome P450 isoenzymes involved in the deamination of phenethylamine-derived designer drugs (2C-series). Biochem Pharmacol 73:287–297PubMedCrossRef Theobald DS, Maurer HH (2007) Identification of monoamine oxidase and cytochrome P450 isoenzymes involved in the deamination of phenethylamine-derived designer drugs (2C-series). Biochem Pharmacol 73:287–297PubMedCrossRef
13.
Zurück zum Zitat Rösner P, Quednow B, Girreser U, Junge T (2005) Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs). Forensic Sci Int 148:143–156PubMedCrossRef Rösner P, Quednow B, Girreser U, Junge T (2005) Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs). Forensic Sci Int 148:143–156PubMedCrossRef
14.
Zurück zum Zitat Gosav S, Dinica R, Praisler M (2008) Choosing between GC–FTIR and GC–MS spectra for an efficient intelligent identification of illicit amphetamines. J Mol Struct 887:269–278CrossRef Gosav S, Dinica R, Praisler M (2008) Choosing between GC–FTIR and GC–MS spectra for an efficient intelligent identification of illicit amphetamines. J Mol Struct 887:269–278CrossRef
15.
Zurück zum Zitat Junet R (1956) Ethylamphetamine in the treatment of obesity. Praxis 45:986–988 (article in French) Junet R (1956) Ethylamphetamine in the treatment of obesity. Praxis 45:986–988 (article in French)
16.
Zurück zum Zitat Oberlender R, Nicholas DE (1991) Structural variation and (+)-amphetamine like discriminative stimulus properties. Pharmacol Biochem Behav 38:581–586PubMedCrossRef Oberlender R, Nicholas DE (1991) Structural variation and (+)-amphetamine like discriminative stimulus properties. Pharmacol Biochem Behav 38:581–586PubMedCrossRef
17.
Zurück zum Zitat Nicholas DE (1986) Differences between the mechanism of action of MDMA, MBDB, and the classic hallucinogens. Identification of a new therapeutic class: entactogens. J Psychoactive Drugs 18:305–313CrossRef Nicholas DE (1986) Differences between the mechanism of action of MDMA, MBDB, and the classic hallucinogens. Identification of a new therapeutic class: entactogens. J Psychoactive Drugs 18:305–313CrossRef
18.
Zurück zum Zitat Misuse of Drugs Act 1971. Parliament of the United Kingdom, May 1971 Misuse of Drugs Act 1971. Parliament of the United Kingdom, May 1971
Metadaten
Titel
Identification of N-ethyl-α-ethylphenethylamine in crystalline powder seized for suspected drug trafficking: a research chemical or a new designer drug?
verfasst von
Jaesin Lee
Sanggil Choe
Hyeyoung Choi
Sewoong Heo
Eunmi Kim
Hyunju Kim
Eunjung Bang
Heesun Chung
Publikationsdatum
01.01.2013
Verlag
Springer Japan
Erschienen in
Forensic Toxicology / Ausgabe 1/2013
Print ISSN: 1860-8965
Elektronische ISSN: 1860-8973
DOI
https://doi.org/10.1007/s11419-012-0158-1

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