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Angiogenesis

Erschienen in:

01.12.2006 | Original paper

Image analysis measurements of the microvascularisation in endometrium, superficial and deep endometriotic tissues

verfasst von: M. Jondet, M. C. Vacher-Lavenu, C. Chapron

Erschienen in: Angiogenesis | Ausgabe 4/2006

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Abstract

The aim of this study was to evaluate precisely the microvascularisation of endometrium, superficial and deep endometriotic lesions, in progestin-treated and non-treated patients suffering from endometriosis.

Methods: A population of 66 women was constituted. Immunohistochemistry was carried out with a specific marker of the endothelial cells (CD31). The number of vessels and the vessel area were assessed by a computer image analysis system.

Results: The number of vessels per mm² were 211, 216, 225 and the vessel area was 270, 141 and 194 μm², respectively in endometria, superficial and deep endometriotic lesions of untreated women. In endometria, superficial and deep endometriotic lesions of progestin-treated women the number of vessels were respectively 129, 149, and 181 per mm² and the vessel area was 369, 474 and 254 μm².

Conclusion: Statistically significant data indicate that endometriotic lesions are heterogeneous and suggest that progestin treatment induces a reduction in number and a concomitant dilation of microvessels with more microvascular changes in endometrium and superficial endometriotic lesions than in deep endometriotic lesions.

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Titel: Image analysis measurements of the microvascularisation in endometrium, superficial and deep endometriotic tissues
verfasst von: M. Jondet
M. C. Vacher-Lavenu
C. Chapron
Publikationsdatum: 01.12.2006
Verlag: Kluwer Academic Publishers
Erschienen in: Angiogenesis / Ausgabe 4/2006
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-006-9044-y

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