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Erschienen in: Skeletal Radiology 11/2023

17.01.2023 | Review Article

Imaging of joint response to exercise with MRI and PET

verfasst von: Lauren E. Watkins, Ananya Goyal, Anthony A. Gatti, Feliks Kogan

Erschienen in: Skeletal Radiology | Ausgabe 11/2023

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Abstract

Imaging of the joint in response to loading stress may provide additional measures of joint structure and function beyond conventional, static imaging studies. Exercise such as running, stair climbing, and squatting allows evaluation of the joint response to larger loading forces than during weight bearing. Quantitative MRI (qMRI) may assess properties of cartilage and meniscus hydration and organization in vivo that have been investigated to assess the functional response of these tissues to physiological stress. [18F]sodium fluoride ([18F]NaF) interrogates areas of newly mineralizing bone and provides an opportunity to study bone physiology, including perfusion and mineralization rate, as a measure of joint loading stress. In this review article, methods utilizing quantitative MRI, PET, and hybrid PET-MRI systems for assessment of the joint response to loading from exercise in vivo are examined. Both methodology and results of various studies performed are outlined and discussed. Lastly, the technical considerations, challenges, and future opportunities for these approaches are addressed.
Literatur
1.
Zurück zum Zitat Skou ST, Bricca A, Roos EM. The impact of physical activity level on the short- and long-term pain relief from supervised exercise therapy and education: a study of 12,796 Danish patients with knee osteoarthritis. Osteoarthr Cartil. 2018;26(11):1474–8.PubMedCrossRef Skou ST, Bricca A, Roos EM. The impact of physical activity level on the short- and long-term pain relief from supervised exercise therapy and education: a study of 12,796 Danish patients with knee osteoarthritis. Osteoarthr Cartil. 2018;26(11):1474–8.PubMedCrossRef
3.
Zurück zum Zitat Chang SH, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-kappaB pathway. Nat Commun. 2019;10(1):1442.PubMedPubMedCentralCrossRef Chang SH, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-kappaB pathway. Nat Commun. 2019;10(1):1442.PubMedPubMedCentralCrossRef
4.
Zurück zum Zitat Roemer FW, Demehri S, Omoumi P, Link TM, Kijowski R, Saarakkala S, et al. State of the art: imaging of osteoarthritis-revisited 2020. Radiology. 2020;296(1):5–21.PubMedCrossRef Roemer FW, Demehri S, Omoumi P, Link TM, Kijowski R, Saarakkala S, et al. State of the art: imaging of osteoarthritis-revisited 2020. Radiology. 2020;296(1):5–21.PubMedCrossRef
5.
Zurück zum Zitat Oei EH, van Tiel J, Robinson WH, Gold GE. Quantitative radiological imaging techniques for articular cartilage composition: towards early diagnosis and development of disease-modifying therapeutics for osteoarthritis. Arthritis Care Res. 2014;66(8):1129–41.CrossRef Oei EH, van Tiel J, Robinson WH, Gold GE. Quantitative radiological imaging techniques for articular cartilage composition: towards early diagnosis and development of disease-modifying therapeutics for osteoarthritis. Arthritis Care Res. 2014;66(8):1129–41.CrossRef
6.
Zurück zum Zitat Bae WC, Du J, Bydder GM, Chung CB. Conventional and ultrashort time-to-echo magnetic resonance imaging of articular cartilage, meniscus, and intervertebral disk. Top Magn Reson Imaging. 2010;21(5):275–89.PubMedPubMedCentralCrossRef Bae WC, Du J, Bydder GM, Chung CB. Conventional and ultrashort time-to-echo magnetic resonance imaging of articular cartilage, meniscus, and intervertebral disk. Top Magn Reson Imaging. 2010;21(5):275–89.PubMedPubMedCentralCrossRef
7.
Zurück zum Zitat Czernin J, Satyamurthy N, Schiepers C. Molecular mechanisms of bone 18F-NaF deposition. J Nucl Med. 2010;51(12):1826–9.PubMedCrossRef Czernin J, Satyamurthy N, Schiepers C. Molecular mechanisms of bone 18F-NaF deposition. J Nucl Med. 2010;51(12):1826–9.PubMedCrossRef
8.
Zurück zum Zitat Turmezei TD, Low SB, Rupret S, Treece GM, Gee AH, MacKay JW, et al. Multiparametric 3-D analysis of bone and joint space width at the knee from weight bearing computed tomography. Osteoarthr Imaging. 2022;2(2):100069. Turmezei TD, Low SB, Rupret S, Treece GM, Gee AH, MacKay JW, et al. Multiparametric 3-D analysis of bone and joint space width at the knee from weight bearing computed tomography. Osteoarthr Imaging. 2022;2(2):100069.
9.
Zurück zum Zitat Barg A, Bailey T, Richter M, de Cesar NC, Lintz F, Burssens A, et al. Weightbearing computed tomography of the foot and ankle: emerging technology topical review. Foot Ankle Int. 2018;39(3):376–86.PubMedCrossRef Barg A, Bailey T, Richter M, de Cesar NC, Lintz F, Burssens A, et al. Weightbearing computed tomography of the foot and ankle: emerging technology topical review. Foot Ankle Int. 2018;39(3):376–86.PubMedCrossRef
10.
Zurück zum Zitat Zevenbergen L, Gsell W, Cai L, Chan DD, Famaey N, Vander Sloten J, et al. Cartilage-on-cartilage contact: effect of compressive loading on tissue deformations and structural integrity of bovine articular cartilage. Osteoarthr Cartil. 2018;26(12):1699–709.PubMedCrossRef Zevenbergen L, Gsell W, Cai L, Chan DD, Famaey N, Vander Sloten J, et al. Cartilage-on-cartilage contact: effect of compressive loading on tissue deformations and structural integrity of bovine articular cartilage. Osteoarthr Cartil. 2018;26(12):1699–709.PubMedCrossRef
11.
Zurück zum Zitat Jerban S, Chang EY, Du J. Magnetic resonance imaging (MRI) studies of knee joint under mechanical loading: Review. Magn Reson Imaging. 2020;65:27–36.PubMedCrossRef Jerban S, Chang EY, Du J. Magnetic resonance imaging (MRI) studies of knee joint under mechanical loading: Review. Magn Reson Imaging. 2020;65:27–36.PubMedCrossRef
12.
Zurück zum Zitat Bruno F, Barile A, Arrigoni F, Laporta A, Russo A, Carotti M, et al. Weight-bearing MRI of the knee: a review of advantages and limits. Acta Biomed. 2018;89(1-S):78–88.PubMedPubMedCentral Bruno F, Barile A, Arrigoni F, Laporta A, Russo A, Carotti M, et al. Weight-bearing MRI of the knee: a review of advantages and limits. Acta Biomed. 2018;89(1-S):78–88.PubMedPubMedCentral
13.
Zurück zum Zitat Ye D, Sun X, Zhang C, Zhang S, Zhang X, Wang S, et al. In vivo foot and ankle kinematics during activities measured by using a dual fluoroscopic imaging system: a narrative review. Front Bioeng Biotechnol. 2021;9:693806.PubMedPubMedCentralCrossRef Ye D, Sun X, Zhang C, Zhang S, Zhang X, Wang S, et al. In vivo foot and ankle kinematics during activities measured by using a dual fluoroscopic imaging system: a narrative review. Front Bioeng Biotechnol. 2021;9:693806.PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Li X, Majumdar S. Quantitative MRI of articular cartilage and its clinical applications. J Magn Reson Imaging. 2013;38(5):991–1008.PubMedCrossRef Li X, Majumdar S. Quantitative MRI of articular cartilage and its clinical applications. J Magn Reson Imaging. 2013;38(5):991–1008.PubMedCrossRef
15.
Zurück zum Zitat Chu CR, Williams AA. Quantitative MRI UTE-T2* and T2* show progressive and continued graft maturation over 2 years in human patients after anterior cruciate ligament reconstruction. Orthop J Sports Med. 2019;7(8):2325967119863056.PubMedPubMedCentralCrossRef Chu CR, Williams AA. Quantitative MRI UTE-T2* and T2* show progressive and continued graft maturation over 2 years in human patients after anterior cruciate ligament reconstruction. Orthop J Sports Med. 2019;7(8):2325967119863056.PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Mazzoli V, Uhlrich S, Rubin EB, Kogan F, Hargreaves B, Delp S, et al. editors. Gait retraining as a conservative treatment for medial knee OA: preliminary findings. In: Proceedings of 27th Annual Meeting of ISMRM; May 11–16, 2019. Montreal, Quebec, Canada: Abstract 0864. Mazzoli V, Uhlrich S, Rubin EB, Kogan F, Hargreaves B, Delp S, et al. editors. Gait retraining as a conservative treatment for medial knee OA: preliminary findings. In: Proceedings of 27th Annual Meeting of ISMRM; May 11–16, 2019. Montreal, Quebec, Canada: Abstract 0864.
17.
Zurück zum Zitat Chaudhari AS, Sveinsson B, Moran CJ, McWalter EJ, Johnson EM, Zhang T, et al. Imaging and T2 relaxometry of short-T2 connective tissues in the knee using ultrashort echo-time double-echo steady-state (UTEDESS). Magn Reson Med. 2017;78(6):2136–48.PubMedPubMedCentralCrossRef Chaudhari AS, Sveinsson B, Moran CJ, McWalter EJ, Johnson EM, Zhang T, et al. Imaging and T2 relaxometry of short-T2 connective tissues in the knee using ultrashort echo-time double-echo steady-state (UTEDESS). Magn Reson Med. 2017;78(6):2136–48.PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat Borthakur A, Mellon E, Niyogi S, Witschey W, Kneeland JB, Reddy R. Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage. NMR Biomed. 2006;19(7):781–821.PubMedPubMedCentralCrossRef Borthakur A, Mellon E, Niyogi S, Witschey W, Kneeland JB, Reddy R. Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage. NMR Biomed. 2006;19(7):781–821.PubMedPubMedCentralCrossRef
19.
Zurück zum Zitat Khan MCM, O’Donovan J, Charlton JM, Roy JS, Hunt MA, Esculier JF. The influence of running on lower limb cartilage: a systematic review and meta-analysis. Sports Med. 2022;52(1):55–74.PubMedCrossRef Khan MCM, O’Donovan J, Charlton JM, Roy JS, Hunt MA, Esculier JF. The influence of running on lower limb cartilage: a systematic review and meta-analysis. Sports Med. 2022;52(1):55–74.PubMedCrossRef
20.
Zurück zum Zitat Esculier JF, Jarrett M, Krowchuk NM, Rauscher A, Wiggermann V, Taunton JE, et al. Cartilage recovery in runners with and without knee osteoarthritis: a pilot study. Knee. 2019;26(5):1049–57.PubMedCrossRef Esculier JF, Jarrett M, Krowchuk NM, Rauscher A, Wiggermann V, Taunton JE, et al. Cartilage recovery in runners with and without knee osteoarthritis: a pilot study. Knee. 2019;26(5):1049–57.PubMedCrossRef
21.
Zurück zum Zitat Gatti AA, Noseworthy MD, Stratford PW, Brenneman EC, Totterman S, Tamez-Pena J, et al. Acute changes in knee cartilage transverse relaxation time after running and bicycling. J Biomech. 2017;53:171–7.PubMedCrossRef Gatti AA, Noseworthy MD, Stratford PW, Brenneman EC, Totterman S, Tamez-Pena J, et al. Acute changes in knee cartilage transverse relaxation time after running and bicycling. J Biomech. 2017;53:171–7.PubMedCrossRef
22.
Zurück zum Zitat Chen M, Qiu L, Shen S, Wang F, Zhang J, Zhang C, et al. The influences of walking, running and stair activity on knee articular cartilage: quantitative MRI using T1 rho and T2 mapping. PLoS One. 2017;12(11):e0187008.PubMedPubMedCentralCrossRef Chen M, Qiu L, Shen S, Wang F, Zhang J, Zhang C, et al. The influences of walking, running and stair activity on knee articular cartilage: quantitative MRI using T1 rho and T2 mapping. PLoS One. 2017;12(11):e0187008.PubMedPubMedCentralCrossRef
23.
Zurück zum Zitat Subburaj K, Kumar D, Souza RB, Alizai H, Li X, Link TM, et al. The acute effect of running on knee articular cartilage and meniscus magnetic resonance relaxation times in young healthy adults. Am J Sports Med. 2012;40(9):2134–41.PubMedPubMedCentralCrossRef Subburaj K, Kumar D, Souza RB, Alizai H, Li X, Link TM, et al. The acute effect of running on knee articular cartilage and meniscus magnetic resonance relaxation times in young healthy adults. Am J Sports Med. 2012;40(9):2134–41.PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat Behzadi C, Welsch GH, Laqmani A, Henes FO, Kaul MG, Schoen G, et al. The immediate effect of long-distance running on T2 and T2* relaxation times of articular cartilage of the knee in young healthy adults at 3.0 T MR imaging. Br J Radiol. 2016;89(1064):20151075.PubMedPubMedCentralCrossRef Behzadi C, Welsch GH, Laqmani A, Henes FO, Kaul MG, Schoen G, et al. The immediate effect of long-distance running on T2 and T2* relaxation times of articular cartilage of the knee in young healthy adults at 3.0 T MR imaging. Br J Radiol. 2016;89(1064):20151075.PubMedPubMedCentralCrossRef
25.
Zurück zum Zitat Mosher TJ, Smith HE, Collins C, Liu Y, Hancy J, Dardzinski BJ, et al. Change in knee cartilage T2 at MR imaging after running: a feasibility study. Radiology. 2005;234(1):245–9.PubMedCrossRef Mosher TJ, Smith HE, Collins C, Liu Y, Hancy J, Dardzinski BJ, et al. Change in knee cartilage T2 at MR imaging after running: a feasibility study. Radiology. 2005;234(1):245–9.PubMedCrossRef
26.
Zurück zum Zitat Crowder HA, Mazzoli V, Black MS, Watkins LE, Kogan F, Hargreaves BA, et al. Characterizing the transient response of knee cartilage to running: decreases in cartilage T2 of female recreational runners. J Orthop Res. 2021;39(11):2340–52.PubMedPubMedCentralCrossRef Crowder HA, Mazzoli V, Black MS, Watkins LE, Kogan F, Hargreaves BA, et al. Characterizing the transient response of knee cartilage to running: decreases in cartilage T2 of female recreational runners. J Orthop Res. 2021;39(11):2340–52.PubMedPubMedCentralCrossRef
27.
Zurück zum Zitat Kyung Kim H, Fernandez J, Logan C, Tarr GP, Doyle A, Mirjalili SA. T2 relaxation time measurements in tibiotalar cartilage after barefoot running and its relationship to ankle biomechanics. J Biomech. 2019;90:103–12.PubMedCrossRef Kyung Kim H, Fernandez J, Logan C, Tarr GP, Doyle A, Mirjalili SA. T2 relaxation time measurements in tibiotalar cartilage after barefoot running and its relationship to ankle biomechanics. J Biomech. 2019;90:103–12.PubMedCrossRef
28.
Zurück zum Zitat Mosher TJ, Liu Y, Torok CM. Functional cartilage MRI T2 mapping: evaluating the effect of age and training on knee cartilage response to running. Osteoarthr Cartil. 2010;18(3):358–64.CrossRef Mosher TJ, Liu Y, Torok CM. Functional cartilage MRI T2 mapping: evaluating the effect of age and training on knee cartilage response to running. Osteoarthr Cartil. 2010;18(3):358–64.CrossRef
29.
Zurück zum Zitat Wang Z, Ai S, Tian F, Liow MHL, Wang S, Zhao J, et al. Higher body mass index is associated with biochemical changes in knee articular cartilage after marathon running: a quantitative T2-relaxation MRI study. Orthop J Sports Med. 2020;8(8):2325967120943874.PubMedPubMedCentralCrossRef Wang Z, Ai S, Tian F, Liow MHL, Wang S, Zhao J, et al. Higher body mass index is associated with biochemical changes in knee articular cartilage after marathon running: a quantitative T2-relaxation MRI study. Orthop J Sports Med. 2020;8(8):2325967120943874.PubMedPubMedCentralCrossRef
30.
Zurück zum Zitat Brenneman Wilson EC, Gatti AA, Keir PJ, Maly MR. Daily cumulative load and body mass index alter knee cartilage response to running in women. Gait Posture. 2021;88:192–7.PubMedCrossRef Brenneman Wilson EC, Gatti AA, Keir PJ, Maly MR. Daily cumulative load and body mass index alter knee cartilage response to running in women. Gait Posture. 2021;88:192–7.PubMedCrossRef
31.
Zurück zum Zitat Collins AT, Kulvaranon ML, Cutcliffe HC, Utturkar GM, Smith WAR, Spritzer CE, et al. Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI. Arthritis Res Ther. 2018;20(1):232.PubMedPubMedCentralCrossRef Collins AT, Kulvaranon ML, Cutcliffe HC, Utturkar GM, Smith WAR, Spritzer CE, et al. Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI. Arthritis Res Ther. 2018;20(1):232.PubMedPubMedCentralCrossRef
32.
Zurück zum Zitat Zhang X, Li J, Ren C, Zhang P, Zeng Y, Zhang R, et al. Periodical assessment of four horns of knee meniscus using MR T2 mapping imaging in volunteers before and after amateur marathons. Sci Rep. 2022;12(1):12093.PubMedPubMedCentralCrossRef Zhang X, Li J, Ren C, Zhang P, Zeng Y, Zhang R, et al. Periodical assessment of four horns of knee meniscus using MR T2 mapping imaging in volunteers before and after amateur marathons. Sci Rep. 2022;12(1):12093.PubMedPubMedCentralCrossRef
33.
Zurück zum Zitat Liess C, Lusse S, Karger N, Heller M, Gluer CC. Detection of changes in cartilage water content using MRI T2-mapping in vivo. Osteoarthr Cartil. 2002;10(12):907–13.CrossRef Liess C, Lusse S, Karger N, Heller M, Gluer CC. Detection of changes in cartilage water content using MRI T2-mapping in vivo. Osteoarthr Cartil. 2002;10(12):907–13.CrossRef
34.
Zurück zum Zitat Watkins LE, Haddock B, MacKay JW, Baker J, Uhlrich SD, Mazzoli V, et al. [(18)F]Sodium fluoride PET-MRI detects increased metabolic bone response to whole-joint loading stress in osteoarthritic knees. Osteoarthr Cartil. 2022;30(11):1515–25.CrossRef Watkins LE, Haddock B, MacKay JW, Baker J, Uhlrich SD, Mazzoli V, et al. [(18)F]Sodium fluoride PET-MRI detects increased metabolic bone response to whole-joint loading stress in osteoarthritic knees. Osteoarthr Cartil. 2022;30(11):1515–25.CrossRef
35.
Zurück zum Zitat Goyal A, Gold G, Kogan F, Watkins L, editors. Changes in meniscus T2 relaxation times due to acute exercise in individuals with knee osteoarthritis. Proceedings of 29th Annual Meeting of ISMRM; May 15–21, 2021; Online; Abstract 4236. Goyal A, Gold G, Kogan F, Watkins L, editors. Changes in meniscus T2 relaxation times due to acute exercise in individuals with knee osteoarthritis. Proceedings of 29th Annual Meeting of ISMRM; May 15–21, 2021; Online; Abstract 4236.
36.
Zurück zum Zitat Lu XL, Mow VC. Biomechanics of articular cartilage and determination of material properties. Med Sci Sports Exerc. 2008;40(2):193–9.PubMedCrossRef Lu XL, Mow VC. Biomechanics of articular cartilage and determination of material properties. Med Sci Sports Exerc. 2008;40(2):193–9.PubMedCrossRef
37.
Zurück zum Zitat Gatti AA, Keir PJ, Noseworthy MD, Maly MR. Investigating acute changes in osteoarthritic cartilage by integrating biomechanics and statistical shape models of bone: data from the osteoarthritis initiative. MAGMA. 2022;35(5):861–73.PubMedPubMedCentralCrossRef Gatti AA, Keir PJ, Noseworthy MD, Maly MR. Investigating acute changes in osteoarthritic cartilage by integrating biomechanics and statistical shape models of bone: data from the osteoarthritis initiative. MAGMA. 2022;35(5):861–73.PubMedPubMedCentralCrossRef
38.
Zurück zum Zitat Farrokhi S, Colletti PM, Powers CM. Differences in patellar cartilage thickness, transverse relaxation time, and deformational behavior: a comparison of young women with and without patellofemoral pain. Am J Sports Med. 2011;39(2):384–91.PubMedCrossRef Farrokhi S, Colletti PM, Powers CM. Differences in patellar cartilage thickness, transverse relaxation time, and deformational behavior: a comparison of young women with and without patellofemoral pain. Am J Sports Med. 2011;39(2):384–91.PubMedCrossRef
39.
Zurück zum Zitat Cha JG, Lee JC, Kim HJ, Han JK, Lee EH, Kim YD, et al. Comparison of MRI T2 relaxation changes of knee articular cartilage before and after running between young and old amateur athletes. Korean J Radiol. 2012;13(5):594–601.PubMedPubMedCentralCrossRef Cha JG, Lee JC, Kim HJ, Han JK, Lee EH, Kim YD, et al. Comparison of MRI T2 relaxation changes of knee articular cartilage before and after running between young and old amateur athletes. Korean J Radiol. 2012;13(5):594–601.PubMedPubMedCentralCrossRef
40.
Zurück zum Zitat Karanfil Y, Babayeva N, Donmez G, Diren HB, Eryilmaz M, Doral MN, et al. Thirty minutes of running exercise decreases T2 signal intensity but not thickness of the knee joint cartilage: a 3.0-T magnetic resonance imaging study. Cartilage. 2019;10(4):444–50.PubMedCrossRef Karanfil Y, Babayeva N, Donmez G, Diren HB, Eryilmaz M, Doral MN, et al. Thirty minutes of running exercise decreases T2 signal intensity but not thickness of the knee joint cartilage: a 3.0-T magnetic resonance imaging study. Cartilage. 2019;10(4):444–50.PubMedCrossRef
41.
Zurück zum Zitat Qiu L, Perez J, Emerson C, Barrera CM, Zhong J, Nham F, et al. Biochemical changes in knee articular cartilage of novice half-marathon runners. J Int Med Res. 2019;47(11):5671–9.PubMedPubMedCentralCrossRef Qiu L, Perez J, Emerson C, Barrera CM, Zhong J, Nham F, et al. Biochemical changes in knee articular cartilage of novice half-marathon runners. J Int Med Res. 2019;47(11):5671–9.PubMedPubMedCentralCrossRef
43.
Zurück zum Zitat Luke AC, Stehling C, Stahl R, Li X, Kay T, Takamoto S, et al. High-field magnetic resonance imaging assessment of articular cartilage before and after marathon running: does long-distance running lead to cartilage damage? Am J Sports Med. 2010;38(11):2273–80.PubMedCrossRef Luke AC, Stehling C, Stahl R, Li X, Kay T, Takamoto S, et al. High-field magnetic resonance imaging assessment of articular cartilage before and after marathon running: does long-distance running lead to cartilage damage? Am J Sports Med. 2010;38(11):2273–80.PubMedCrossRef
44.
Zurück zum Zitat Stehling C, Luke A, Stahl R, Baum T, Joseph G, Pan J, et al. Meniscal T1rho and T2 measured with 3.0T MRI increases directly after running a marathon. Skelet Radiol. 2011;40(6):725–35. Stehling C, Luke A, Stahl R, Baum T, Joseph G, Pan J, et al. Meniscal T1rho and T2 measured with 3.0T MRI increases directly after running a marathon. Skelet Radiol. 2011;40(6):725–35.
45.
Zurück zum Zitat Nathani A, Gold GE, Monu U, Hargreaves B, Finlay AK, Rubin EB, et al. Does injection of hyaluronic acid protect against early cartilage injury seen after marathon running? A randomized controlled trial utilizing high-field magnetic resonance imaging. Am J Sports Med. 2019;47(14):3414–22.PubMedCrossRef Nathani A, Gold GE, Monu U, Hargreaves B, Finlay AK, Rubin EB, et al. Does injection of hyaluronic acid protect against early cartilage injury seen after marathon running? A randomized controlled trial utilizing high-field magnetic resonance imaging. Am J Sports Med. 2019;47(14):3414–22.PubMedCrossRef
46.
Zurück zum Zitat Kessler DA, MacKay JW, McDonald S, McDonnell S, Grainger AJ, Roberts AR, et al. Effectively measuring exercise-related variations in T1rho and T2 relaxation times of healthy articular cartilage. J Magn Reson Imaging. 2020;52(6):1753–64.PubMedCrossRef Kessler DA, MacKay JW, McDonald S, McDonnell S, Grainger AJ, Roberts AR, et al. Effectively measuring exercise-related variations in T1rho and T2 relaxation times of healthy articular cartilage. J Magn Reson Imaging. 2020;52(6):1753–64.PubMedCrossRef
47.
Zurück zum Zitat Heckelman LN, Smith WAR, Riofrio AD, Vinson EN, Collins AT, Gwynn OR, et al. Quantifying the biochemical state of knee cartilage in response to running using T1rho magnetic resonance imaging. Sci Rep. 2020;10(1):1870.PubMedPubMedCentralCrossRef Heckelman LN, Smith WAR, Riofrio AD, Vinson EN, Collins AT, Gwynn OR, et al. Quantifying the biochemical state of knee cartilage in response to running using T1rho magnetic resonance imaging. Sci Rep. 2020;10(1):1870.PubMedPubMedCentralCrossRef
48.
Zurück zum Zitat Schutz UH, Ellermann J, Schoss D, Wiedelbach H, Beer M, Billich C. Biochemical cartilage alteration and unexpected signal recovery in T2* mapping observed in ankle joints with mobile MRI during a transcontinental multistage footrace over 4486 km. Osteoarthr Cartil. 2014;22(11):1840–50.PubMedCrossRef Schutz UH, Ellermann J, Schoss D, Wiedelbach H, Beer M, Billich C. Biochemical cartilage alteration and unexpected signal recovery in T2* mapping observed in ankle joints with mobile MRI during a transcontinental multistage footrace over 4486 km. Osteoarthr Cartil. 2014;22(11):1840–50.PubMedCrossRef
49.
Zurück zum Zitat Hesper T, Miese FR, Hosalkar HS, Behringer M, Zilkens C, Antoch G, et al. Quantitative T2(*) assessment of knee joint cartilage after running a marathon. Eur J Radiol. 2015;84(2):284–9.PubMedCrossRef Hesper T, Miese FR, Hosalkar HS, Behringer M, Zilkens C, Antoch G, et al. Quantitative T2(*) assessment of knee joint cartilage after running a marathon. Eur J Radiol. 2015;84(2):284–9.PubMedCrossRef
50.
Zurück zum Zitat Schutz U, Ehrhardt M, God S, Billich C, Beer M, Trattnig S. A mobile MRI field study of the biochemical cartilage reaction of the knee joint during a 4,486 km transcontinental multistage ultra-marathon using T2* mapping. Sci Rep. 2020;10(1):8157.PubMedPubMedCentralCrossRef Schutz U, Ehrhardt M, God S, Billich C, Beer M, Trattnig S. A mobile MRI field study of the biochemical cartilage reaction of the knee joint during a 4,486 km transcontinental multistage ultra-marathon using T2* mapping. Sci Rep. 2020;10(1):8157.PubMedPubMedCentralCrossRef
51.
Zurück zum Zitat Zhang P, Yu B, Zhang R, Chen X, Shao S, Zeng Y, et al. Longitudinal study of the morphological and T2* changes of knee cartilages of marathon runners using prototype software for automatic cartilage segmentation. Br J Radiol. 2021;94(1119):20200833.PubMedPubMedCentralCrossRef Zhang P, Yu B, Zhang R, Chen X, Shao S, Zeng Y, et al. Longitudinal study of the morphological and T2* changes of knee cartilages of marathon runners using prototype software for automatic cartilage segmentation. Br J Radiol. 2021;94(1119):20200833.PubMedPubMedCentralCrossRef
52.
Zurück zum Zitat Schutz U, Martensen T, Kleiner S, Dreyhaupt J, Wegener M, Wilke HJ, et al. T2*-mapping of knee cartilage in response to mechanical loading in alpine skiing: a feasibility study. Diagnostics (Basel). 2022;12(6). Schutz U, Martensen T, Kleiner S, Dreyhaupt J, Wegener M, Wilke HJ, et al. T2*-mapping of knee cartilage in response to mechanical loading in alpine skiing: a feasibility study. Diagnostics (Basel). 2022;12(6).
53.
Zurück zum Zitat Kersting UG, Stubendorff JJ, Schmidt MC, Bruggemann GP. Changes in knee cartilage volume and serum COMP concentration after running exercise. Osteoarthr Cartil. 2005;13(10):925–34.CrossRef Kersting UG, Stubendorff JJ, Schmidt MC, Bruggemann GP. Changes in knee cartilage volume and serum COMP concentration after running exercise. Osteoarthr Cartil. 2005;13(10):925–34.CrossRef
54.
Zurück zum Zitat Eckstein F, Lemberger B, Gratzke C, Hudelmaier M, Glaser C, Englmeier KH, et al. In vivo cartilage deformation after different types of activity and its dependence on physical training status. Ann Rheum Dis. 2005;64(2):291–5.PubMedPubMedCentralCrossRef Eckstein F, Lemberger B, Gratzke C, Hudelmaier M, Glaser C, Englmeier KH, et al. In vivo cartilage deformation after different types of activity and its dependence on physical training status. Ann Rheum Dis. 2005;64(2):291–5.PubMedPubMedCentralCrossRef
55.
Zurück zum Zitat Kessler MA, Glaser C, Tittel S, Reiser M, Imhoff AB. Volume changes in the menisci and articular cartilage of runners: an in vivo investigation based on 3-D magnetic resonance imaging. Am J Sports Med. 2006;34(5):832–6.PubMedCrossRef Kessler MA, Glaser C, Tittel S, Reiser M, Imhoff AB. Volume changes in the menisci and articular cartilage of runners: an in vivo investigation based on 3-D magnetic resonance imaging. Am J Sports Med. 2006;34(5):832–6.PubMedCrossRef
56.
Zurück zum Zitat Kessler MA, Glaser C, Tittel S, Reiser M, Imhoff AB. Recovery of the menisci and articular cartilage of runners after cessation of exercise: additional aspects of in vivo investigation based on 3-dimensional magnetic resonance imaging. Am J Sports Med. 2008;36(5):966–70.PubMedCrossRef Kessler MA, Glaser C, Tittel S, Reiser M, Imhoff AB. Recovery of the menisci and articular cartilage of runners after cessation of exercise: additional aspects of in vivo investigation based on 3-dimensional magnetic resonance imaging. Am J Sports Med. 2008;36(5):966–70.PubMedCrossRef
57.
Zurück zum Zitat Boocock M, McNair P, Cicuttini F, Stuart A, Sinclair T. The short-term effects of running on the deformation of knee articular cartilage and its relationship to biomechanical loads at the knee. Osteoarthr Cartil. 2009;17(7):883–90.CrossRef Boocock M, McNair P, Cicuttini F, Stuart A, Sinclair T. The short-term effects of running on the deformation of knee articular cartilage and its relationship to biomechanical loads at the knee. Osteoarthr Cartil. 2009;17(7):883–90.CrossRef
58.
Zurück zum Zitat Niehoff A, Muller M, Bruggemann L, Savage T, Zaucke F, Eckstein F, et al. Deformational behaviour of knee cartilage and changes in serum cartilage oligomeric matrix protein (COMP) after running and drop landing. Osteoarthr Cartil. 2011;19(8):1003–10.CrossRef Niehoff A, Muller M, Bruggemann L, Savage T, Zaucke F, Eckstein F, et al. Deformational behaviour of knee cartilage and changes in serum cartilage oligomeric matrix protein (COMP) after running and drop landing. Osteoarthr Cartil. 2011;19(8):1003–10.CrossRef
59.
Zurück zum Zitat Bratke G, Bruggemann GP, Willwacher S, Mahlich D, Trudeau MB, Rohr E, et al. Does footwear affect articular cartilage volume change after a prolonged run? Scand J Med Sci Sports. 2020;30(2):332–8.PubMedCrossRef Bratke G, Bruggemann GP, Willwacher S, Mahlich D, Trudeau MB, Rohr E, et al. Does footwear affect articular cartilage volume change after a prolonged run? Scand J Med Sci Sports. 2020;30(2):332–8.PubMedCrossRef
60.
Zurück zum Zitat Chalian M, Li X, Guermazi A, Obuchowski NA, Carrino JA, Oei EH, et al. The QIBA profile for MRI-based compositional imaging of knee cartilage. Radiology. 2021;301(2):423–32.PubMedCrossRef Chalian M, Li X, Guermazi A, Obuchowski NA, Carrino JA, Oei EH, et al. The QIBA profile for MRI-based compositional imaging of knee cartilage. Radiology. 2021;301(2):423–32.PubMedCrossRef
61.
Zurück zum Zitat Du J, Bydder M, Takahashi AM, Carl M, Chung CB, Bydder GM. Short T2 contrast with three-dimensional ultrashort echo time imaging. Magn Reson Imaging. 2011;29(4):470–82.PubMedPubMedCentralCrossRef Du J, Bydder M, Takahashi AM, Carl M, Chung CB, Bydder GM. Short T2 contrast with three-dimensional ultrashort echo time imaging. Magn Reson Imaging. 2011;29(4):470–82.PubMedPubMedCentralCrossRef
62.
Zurück zum Zitat Silva MJ, Uthgenannt BA, Rutlin JR, Wohl GR, Lewis JS, Welch MJ. In vivo skeletal imaging of 18F-fluoride with positron emission tomography reveals damage- and time-dependent responses to fatigue loading in the rat ulna. Bone. 2006;39(2):229–36.PubMedCrossRef Silva MJ, Uthgenannt BA, Rutlin JR, Wohl GR, Lewis JS, Welch MJ. In vivo skeletal imaging of 18F-fluoride with positron emission tomography reveals damage- and time-dependent responses to fatigue loading in the rat ulna. Bone. 2006;39(2):229–36.PubMedCrossRef
63.
Zurück zum Zitat Tomlinson RE, Silva MJ, Shoghi KI. Quantification of skeletal blood flow and fluoride metabolism in rats using PET in a pre-clinical stress fracture model. Mol Imaging Biol. 2012;14(3):348–54.PubMedPubMedCentralCrossRef Tomlinson RE, Silva MJ, Shoghi KI. Quantification of skeletal blood flow and fluoride metabolism in rats using PET in a pre-clinical stress fracture model. Mol Imaging Biol. 2012;14(3):348–54.PubMedPubMedCentralCrossRef
64.
Zurück zum Zitat Haddock B, Fan AP, Uhlrich SD, Jorgensen NR, Suetta C, Gold GE, et al. Assessment of acute bone loading in humans using [(18)F]NaF PET/MRI. Eur J Nucl Med Mol Imaging. 2019;46(12):2452–63.PubMedPubMedCentralCrossRef Haddock B, Fan AP, Uhlrich SD, Jorgensen NR, Suetta C, Gold GE, et al. Assessment of acute bone loading in humans using [(18)F]NaF PET/MRI. Eur J Nucl Med Mol Imaging. 2019;46(12):2452–63.PubMedPubMedCentralCrossRef
65.
Zurück zum Zitat Hawkins RA, Choi Y, Huang SC, Hoh CK, Dahlbom M, Schiepers C, et al. Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET. J Nucl Med. 1992;33(5):633–42.PubMed Hawkins RA, Choi Y, Huang SC, Hoh CK, Dahlbom M, Schiepers C, et al. Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET. J Nucl Med. 1992;33(5):633–42.PubMed
67.
Zurück zum Zitat Besier TF, Gold GE, Delp SL, Fredericson M, Beaupre GS. The influence of femoral internal and external rotation on cartilage stresses within the patellofemoral joint. J Orthop Res. 2008;26(12):1627–35.PubMedCrossRef Besier TF, Gold GE, Delp SL, Fredericson M, Beaupre GS. The influence of femoral internal and external rotation on cartilage stresses within the patellofemoral joint. J Orthop Res. 2008;26(12):1627–35.PubMedCrossRef
68.
Zurück zum Zitat Gatti A, Haddock B, Alcantara R, St. Pierre S, Peirlinck M, Uhlrich S, et al. editors. Validation of [18F]NaF PET as a measure of bone remodeling using finite element analysis. North American Congress on Biomechanics; 2022. Gatti A, Haddock B, Alcantara R, St. Pierre S, Peirlinck M, Uhlrich S, et al. editors. Validation of [18F]NaF PET as a measure of bone remodeling using finite element analysis. North American Congress on Biomechanics; 2022.
69.
Zurück zum Zitat Klein-Nulend J, van Oers RF, Bakker AD, Bacabac RG. Bone cell mechanosensitivity, estrogen deficiency, and osteoporosis. J Biomech. 2015;48(5):855–65.PubMedCrossRef Klein-Nulend J, van Oers RF, Bakker AD, Bacabac RG. Bone cell mechanosensitivity, estrogen deficiency, and osteoporosis. J Biomech. 2015;48(5):855–65.PubMedCrossRef
70.
71.
Zurück zum Zitat Watkins L, MacKay J, Haddock B, Mazzoli V, Uhlrich S, Gold G, et al. Assessment of quantitative [(18)F]Sodium fluoride PET measures of knee subchondral bone perfusion and mineralization in osteoarthritic and healthy subjects. Osteoarthr Cartil. 2021. Watkins L, MacKay J, Haddock B, Mazzoli V, Uhlrich S, Gold G, et al. Assessment of quantitative [(18)F]Sodium fluoride PET measures of knee subchondral bone perfusion and mineralization in osteoarthritic and healthy subjects. Osteoarthr Cartil. 2021.
72.
Zurück zum Zitat Savic D, Pedoia V, Seo Y, Yang J, Bucknor M, Franc BL, et al. Imaging bone-cartilage interactions in osteoarthritis using [18F]-NaF PET-MRI. Mol Imaging. 2016;15:1–12.PubMedCrossRef Savic D, Pedoia V, Seo Y, Yang J, Bucknor M, Franc BL, et al. Imaging bone-cartilage interactions in osteoarthritis using [18F]-NaF PET-MRI. Mol Imaging. 2016;15:1–12.PubMedCrossRef
73.
Zurück zum Zitat Tibrewala R, Bahroos E, Mehrabian H, Foreman SC, Link TM, Pedoia V, et al. [(18) F]-Sodium fluoride PET/MR imaging for bone-cartilage interactions in hip osteoarthritis: a feasibility study. J Orthop Res. 2019;37(12):2671–80.PubMedPubMedCentralCrossRef Tibrewala R, Bahroos E, Mehrabian H, Foreman SC, Link TM, Pedoia V, et al. [(18) F]-Sodium fluoride PET/MR imaging for bone-cartilage interactions in hip osteoarthritis: a feasibility study. J Orthop Res. 2019;37(12):2671–80.PubMedPubMedCentralCrossRef
74.
Zurück zum Zitat Tibrewala R, Pedoia V, Bucknor M, Majumdar S. Principal component analysis of simultaneous PET-MRI reveals patterns of bone-cartilage interactions in osteoarthritis. J Magn Reson Imaging. 2020;52(5):1462–74.PubMedCrossRef Tibrewala R, Pedoia V, Bucknor M, Majumdar S. Principal component analysis of simultaneous PET-MRI reveals patterns of bone-cartilage interactions in osteoarthritis. J Magn Reson Imaging. 2020;52(5):1462–74.PubMedCrossRef
75.
Zurück zum Zitat Kogan F, Fan AP, Monu UD, Iagaru A, Hargreaves BA, Gold GE. Quantitative imaging of bone-cartilage interactions in ACL-injured patients with PET-MRI. Osteoarthr Cartil. 2018;26(6):790–6.CrossRef Kogan F, Fan AP, Monu UD, Iagaru A, Hargreaves BA, Gold GE. Quantitative imaging of bone-cartilage interactions in ACL-injured patients with PET-MRI. Osteoarthr Cartil. 2018;26(6):790–6.CrossRef
Metadaten
Titel
Imaging of joint response to exercise with MRI and PET
verfasst von
Lauren E. Watkins
Ananya Goyal
Anthony A. Gatti
Feliks Kogan
Publikationsdatum
17.01.2023
Verlag
Springer Berlin Heidelberg
Erschienen in
Skeletal Radiology / Ausgabe 11/2023
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-022-04271-7

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