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01.04.2016 | Original Article

Immediate tooth replantation in rats: effect of systemic antibiotic therapy with amoxicillin and tetracycline

verfasst von: Moriel Evangelista Melo, Cristina Antoniali Silva, Weglis Dyanne de Souza Gomes, Vanessa Ferreira da Silva, Daniela Atili Brandini, Wilson Roberto Poi, Lithiene Ribeiro Castilho, Celso Koogi Sonoda, Sônia Regina Panzarini

Erschienen in: Clinical Oral Investigations | Ausgabe 3/2016

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Abstract

Objectives

The aim of this study was to evaluate the influence of systemic administration of antibiotics (amoxicillin and tetracycline) at the different phases of the repair process (7, 15, 30 days) in immediate rat tooth replantation.

Materials and methods

Ninety rats had their incisors extracted and stored in saline for 5 min. Next, the teeth were replanted, and the animals were assigned to three groups according to the antibiotic administered by oral gavage: control group, amoxycillin group, and tetracycline group. Euthanasia was performed at 7, 15, and 30 days after replantation.

Results

Regardless of the evaluation period, the connective tissue underlying the epithelial attachment and the periodontal ligament showed statistically significant difference relative to the acute inflammatory infiltrate, which was more intense in the control group followed by the tetracycline group.

Conclusion

These results point to the fact that systemic antibiotic therapy (SAT) in immediate tooth replantation is beneficial to pulpal and periodontal ligament repair and that amoxycillin is an excellent option.

Clinical relevance

There is a lack of randomized studies assessing how the use of systemic antibiotics could influence tooth healing after immediate replantation.

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Titel: Immediate tooth replantation in rats: effect of systemic antibiotic therapy with amoxicillin and tetracycline
verfasst von: Moriel Evangelista Melo
Cristina Antoniali Silva
Weglis Dyanne de Souza Gomes
Vanessa Ferreira da Silva
Daniela Atili Brandini
Wilson Roberto Poi
Lithiene Ribeiro Castilho
Celso Koogi Sonoda
Sônia Regina Panzarini
Publikationsdatum: 01.04.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 3/2016
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-015-1534-0

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Immediate tooth replantation in rats: effect of systemic antibiotic therapy with amoxicillin and tetracycline