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Current HIV/AIDS Reports

Erschienen in:

01.09.2014 | Complications of Antiretroviral Therapy (JM Kilby, Section Editor)

Immune Reconstitution Disorders in Patients With HIV Infection: From Pathogenesis to Prevention and Treatment

verfasst von: C. C. Chang, V. Sheikh, I. Sereti, M. A. French

Erschienen in: Current HIV/AIDS Reports | Ausgabe 3/2014

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Abstract

An immune reconstitution disorder occurs in up to 40 % of severely immunodeficient HIV patients who commence antiretroviral therapy (ART), with an immune reconstitution inflammatory syndrome (IRIS) being encountered most commonly. Differences in the immunopathogenesis of an IRIS associated with different types of pathogen have become apparent but common features have also been defined. These include severe immunodeficiency prior to commencing ART associated with a high pathogen load and ‘compensatory’ immune responses, particularly innate immune responses, which inadequately control the pathogen and increase the risk of immunopathology as the immune system recovers on ART. Prevention of an IRIS may be achieved by optimising therapy for opportunistic infections before ART is commenced, delaying ART or using immunomodulatory therapy to prevent or suppress the immune response that causes the immunopathology. However, further clinical studies are required to examine these options in a systematic manner for the various types of IRIS.

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Titel: Immune Reconstitution Disorders in Patients With HIV Infection: From Pathogenesis to Prevention and Treatment
verfasst von: C. C. Chang
V. Sheikh
I. Sereti
M. A. French
Publikationsdatum: 01.09.2014
Verlag: Springer US
Erschienen in: Current HIV/AIDS Reports / Ausgabe 3/2014
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI: https://doi.org/10.1007/s11904-014-0213-0

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