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Seminars in Immunopathology

Erschienen in:

01.09.2014 | Review

Immune sensing of nucleic acids in inflammatory skin diseases

verfasst von: Olivier Demaria, Jeremy Di Domizio, Michel Gilliet

Erschienen in: Seminars in Immunopathology | Ausgabe 5/2014

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Abstract

Endosomal and cytosolic nucleic acid receptors are important immune sensors required for the detection of infecting or replicating viruses. The intracellular location of these receptors allows viral recognition and, at the same time, avoids unnecessary immune activation to self-nucleic acids that are continuously released by dying host cells. Recent evidence, however, indicates that endogenous factors such as anti-microbial peptides have the ability to break this protective mechanism. Here, we discuss these factors and illustrate how they drive inflammatory responses by promoting immune recognition of self-nucleic acids in skin wounds and inflammatory skin diseases such as psoriasis and lupus.

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Titel: Immune sensing of nucleic acids in inflammatory skin diseases
verfasst von: Olivier Demaria
Jeremy Di Domizio
Michel Gilliet
Publikationsdatum: 01.09.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Seminars in Immunopathology / Ausgabe 5/2014
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-014-0445-5

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