Ausgabe 1/2023
Inhalt (76 Artikel)
Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study
Qian Liu, Zhenshu Li, Ling Huang, Dezheng Zhou, Jingzhu Fu, Huilian Duan, Zehao Wang, Tong Yang, Jing Zhao, Wen Li, Huan Liu, Fei Ma, Changqing Sun, Guangshun Wang, Yue Du, Meilin Zhang, Yongjie Chen, Guowei Huang
Immunosenescence and inflammaging in the aged horse
Sally DeNotta, Dianne McFarlane
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease
E. Costantini, C. Carrarini, P. Borrelli, M. De Rosa, D. Calisi, S. Consoli, D. D’Ardes, F. Cipollone, M. Di Nicola, M. Onofrj, M. Reale, L. Bonanni
Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults
Charles T. Semelka, Michael E. DeWitt, Maria W. Blevins, Beth C. Holbrook, John W. Sanders, Martha A. Alexander-Miller
Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice
Miriam Zamorano, Jenolyn F. Alexander, Desiree Catania, Shruti Dharmaraj, Annemieke Kavelaars, Cobi J. Heijnen
Mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individuals
Anjali M. Byappanahalli, Nicole Noren Hooten, Mya Vannoy, Nicolle A. Mode, Ngozi Ezike, Alan B. Zonderman, Michele K. Evans
Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging
Bin Yang, Chengzhi Lv, Li Ye, Zhen Wang, Yoon Kim, Wenhai Luo, Peter M. Elias, Mao-Qiang Man
Decreased thymic output predicts progression of chronic kidney disease
Kenichiro Iio, Daijiro Kabata, Rei Iio, Shinichi Shibamoto, Yuuki Watanabe, Masashi Morita, Yosuke Imai, Masaki Hatanaka, Hiroki Omori, Yoshitaka Isaka
Higher plasma levels of thymosin-α1 are associated with a lower waning of humoral response after COVID-19 vaccination: an eight months follow-up study in a nursing home
María del Mar Pozo-Balado, Ángel Bulnes-Ramos, Israel Olivas-Martínez, Vanesa Garrido-Rodríguez, Carmen Lozano, Ana I. Álvarez-Ríos, Berta Sánchez-Sánchez, Encarnación Sánchez-Bejarano, Isabel Maldonado-Calzado, José Manuel Martín-Lara, Juan Antonio Santamaría, Rafael Bernal, María Francisca González-Escribano, Manuel Leal, Yolanda M. Pacheco
“Just right” combinations of adjuvants with nanoscale carriers activate aged dendritic cells without overt inflammation
Ananya Ananya, Kaitlyn G. Holden, Zhiling Gu, Dan Nettleton, Surya K. Mallapragada, Michael J. Wannemuehler, Marian L. Kohut, Balaji Narasimhan
Sex-specific innate immunity and ageing in long-lived fresh water turtles (Kinosternon flavescens: Kinosternidae)
Anne M. Bronikowski, Ashley R. Hedrick, Greta A. Kutz, Kaitlyn G. Holden, Beth Reinke, John B. Iverson
Glycyrrhizic acid inhibits myeloid differentiation of hematopoietic stem cells by binding S100 calcium binding protein A8 to improve cognition in aged mice
Xue Gong, Haitao Shen, Liuling Guo, Ce Huang, Tingting Su, Hao Wang, Shengyu Feng, Shanshan Yang, Fenjiao Huo, Haifeng Liu, Jianbo Zhu, Jian-Kang Zhu, Hongbin Li, Hailiang Liu
Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease
Roberto Paganelli, Alessia Paganelli, Graham Pawelec, Angelo Di Iorio
UGRP1-modulated MARCO+ alveolar macrophages contribute to age-related lung fibrosis
Yongyan Chen, Xiaolei Hao, Ming Li, Zhigang Tian, Min Cheng
Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation
Kaiwu He, Lulin Nie, Tahir Ali, Zizhen Liu, Weifen Li, Ruyan Gao, Zena Zhang, Jianjun Liu, Zhongliang Dai, Yongmei Xie, Zaijun Zhang, Gongping Liu, Ming Dong, Zhi-Jian Yu, Shupeng Li, Xifei Yang
Thymic function and survival at advance ages in nursing home residents from Southern Italy
Ersilia Paparazzo, Silvana Geracitano, Vincenzo Lagani, Luigi Citrigno, Denise Bartolomeo, Mirella Aurora Aceto, Francesco Bruno, Raffaele Maletta, Giuseppe Passarino, Alberto Montesanto
Aged brain and neuroimmune responses to COVID-19: post-acute sequelae and modulatory effects of behavioral and nutritional interventions
Ludmila Müller, Svetlana Di Benedetto
The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial
Dominique E. Martin, Andreia N. Cadar, Hunter Panier, Blake L. Torrance, George A. Kuchel, Jenna M. Bartley
12-week combined strength and endurance exercise attenuates CD8+ T-cell differentiation and affects the kynurenine pathway in the elderly: a randomized controlled trial
Tim Konstantin Boßlau, Paulina Wasserfurth, Thomas Reichel, Christopher Weyh, Jana Palmowski, Josefine Nebl, Niklas Joisten, Sergen Belen, Alexander Schenk, Andreas Hahn, Philipp Zimmer, Karsten Krüger
Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice
Bo Ryoung Park, Ramireddy Bommireddy, David Hyunjung Chung, Ki-Hye Kim, Jeeva Subbiah, Yu-Jin Jung, Noopur Bhatnagar, Christopher D. Pack, Sampath Ramachandiran, Shaker J.C. Reddy, Periasamy Selvaraj, Sang-Moo Kang
Single-cell RNA sequencing reveals the local cell landscape in mouse epididymal initial segment during aging
Jintao Zhuang, Xiangping Li, Jiahui Yao, Xiangzhou Sun, Jiumin Liu, Hua Nie, Yang Hu, Xiangan Tu, Huang Liu, Weibing Qin, Yun Xie
Age-related neuroimmune signatures in dorsal root ganglia of a Fabry disease mouse model
Jeiny Luna Choconta, Verena Labi, Cristiana Dumbraveanu, Theodora Kalpachidou, Kai K. Kummer, Michaela Kress
Targeting the hallmarks of aging to improve influenza vaccine responses in older adults
Andreia N. Cadar, Dominique E. Martin, Jenna M. Bartley
Associations between circulating cell-free mitochondrial DNA, inflammatory markers, and cognitive and physical outcomes in community dwelling older adults
Lolita S. Nidadavolu, Danielle Feger, Diefei Chen, Yuqiong Wu, Francine Grodstein, Alden L. Gross, David A. Bennett, Jeremy D. Walston, Esther S. Oh, Peter M. Abadir
Aging and chronic inflammation: highlights from a multidisciplinary workshop
Danay Saavedra, Ana Laura Añé-Kourí, Nir Barzilai, Calogero Caruso, Kyung-Hyun Cho, Luigi Fontana, Claudio Franceschi, Daniela Frasca, Nuris Ledón, Laura J. Niedernhofer, Karla Pereira, Paul D. Robbins, Alexa Silva, Gisela M. Suarez, Wim Vanden Berghe, Thomas von Zglinicki, Graham Pawelec, Agustín Lage
Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4+ T cells specific for the epidermal autoantigen desmoglein 3
Hisato Iriki, Miho Mukai, Yasuhiko Asahina, Yoko Kubo, Hiromi Ito, Masayuki Amagai, Hayato Takahashi
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS
Wenkai Yue, Xue Deng, Zhao Wang, Mingsheng Jiang, Rirong Hu, Yongjia Duan, Qiangqiang Wang, Jihong Cui, Yanshan Fang
Novel nanoadjuvants balance immune activation with modest inflammation: implications for older adult vaccines
Kathleen A. Ross, April M. Tingle, Sujata Senapati, Kaitlyn G. Holden, Michael J. Wannemuehler, Surya K. Mallapragada, Balaji Narasimhan, Marian L. Kohut
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans
Ryan G. Snodgrass, Xiaowen Jiang, Charles B. Stephensen, Kevin D. Laugero
Immunogenicity of adjuvanted versus high-dose inactivated influenza vaccines in older adults: a randomized clinical trial
Kenneth E. Schmader, Christine K. Liu, Brendan Flannery, Wes Rountree, Heidi Auerbach, Elizabeth D. Barnett, Elizabeth P. Schlaudecker, Christopher A. Todd, Marek Poniewierski, Mary A. Staat, Theresa Harrington, Rongxia Li, Karen R. Broder, Emmanuel B. Walter
TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα
Alexandre Poirier, Chenyue Wu, Ana Maria Hincapie, Zuzet Martinez-Cordova, Belma Melda Abidin, Michel L. Tremblay
The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov2
M. S. Espinar-Buitrago, L. Tarancon-Diez, E. Vazquez-Alejo, E. Magro-Lopez, M. Genebat, F. Romero-Candau, M. Leal, M. A. Muñoz-Fernandez
Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals
Leire Iparraguirre, Ainhoa Alberro, Saioa GS Iñiguez, Maider Muñoz-Culla, Itziar Vergara, Ander Matheu, David Otaegui
Aging modifies endometrial dendritic cell function and unconventional double negative T cells in the human genital mucosa
Siddharth Parthasarathy, Zheng Shen, Francisco J. Carrillo-Salinas, Vidya Iyer, Alison Vogell, Diego Illanes, Charles R. Wira, Marta Rodriguez-Garcia
Obesity accelerates age defects in B cells, and weight loss improves B cell function
Daniela Frasca, Maria Romero, Alain Diaz, Bonnie B. Blomberg
Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults: a population-based study
Yongxiang Wang, Qi Han, Xiaolei Han, Yi Dong, Ming Mao, Chaoqun Wang, Xiaojie Wang, Shi Tang, Cuicui Liu, Yuanjing Li, Tingting Hou, Lin Cong, Yifeng Du, Chengxuan Qiu
Immunogenicity and safety of quadrivalent influenza vaccine among young and older adults in Tianjin, China: implication of immunosenescence as a risk factor
Tongling Xiao, Miaomiao Wei, Xiaokun Guo, Yu Zhang, Zhongyan Wang, Xiaoshuang Xia, Xuemei Qi, Lin Wang, Xin Li, Sean X. Leng
Interseason waning of vaccine-induced hemagglutination inhibition antibody titers and contributing factors to pre-existing humoral immunity against influenza in community-dwelling older adults 75 years and older
Bettina Wunderlich, Thomas Laskow, Huifen Li, Li Zhang, Engle Abrams, Jing Tian, Jun Yu, Yiyin Chen, Juliette Tavenier, Yushu Huang, Kawsar Talaat, Jay H. Bream, Qian-Li Xue, Graham Pawelec, Sean X. Leng
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease
Chunrong Li, Kangding Liu, Jie Zhu, Feiqi Zhu
Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection
Olivia B. Parks, Taylor Eddens, Jorna Sojati, Jie Lan, Yu Zhang, Tim D. Oury, Manda Ramsey, John J. Erickson, Craig A. Byersdorfer, John V. Williams
Systemic immune response in young and elderly patients after traumatic brain injury
Marta Magatti, Francesca Pischiutta, Fabrizio Ortolano, Anna Pasotti, Enrico Caruso, Anna Cargnoni, Andrea Papait, Franco Capuzzi, Tommaso Zoerle, Marco Carbonara, Nino Stocchetti, Stefano Borsa, Marco Locatelli, Elisa Erba, Daniele Prati, Antonietta R Silini, Elisa R Zanier, Ornella Parolini
Kinetics of COVID-19 mRNA primary and booster vaccine-associated neutralizing activity against SARS-CoV-2 variants of concern in long-term care facility residents: a prospective longitudinal study in Japan
Tomoyuki Kakugawa, Keiko Doi, Yuichi Ohteru, Hiroyuki Kakugawa, Keiji Oishi, Masahiro Kakugawa, Tsunahiko Hirano, Yusuke Mimura, Kazuto Matsunaga
The intersection of biological sex and gender in adverse events following seasonal influenza vaccination in older adults
Janna R. Shapiro, Kumba Seddu, Han-Sol Park, John S. Lee, Patrick S. Creisher, Anna Yin, Patrick Shea, Helen Kuo, Huifen Li, Engle Abrams, Sean X. Leng, Rosemary Morgan, Sabra L. Klein
Short-term intensive fasting enhances the immune function of red blood cells in humans
Yixuan Fang, Jiawei Qian, Li Xu, Wen Wei, Wenwen Bu, Suping Zhang, Yaqi Lv, Lei Li, Chen Zhao, Xueqin Gao, Yue Gu, Li Wang, Zixing Chen, Xiao Wang, Ruizhi Zhang, Youjia Xu, Yanjun Yang, Jie Lu, Zhanjun Yan, Mingyuan Wang, Longhai Tang, Na Yuan, Jianrong Wang
Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population
Mårten Sandstedt, Rosanna W S Chung, Camilla Skoglund, Anna K. Lundberg, Carl Johan Östgren, Jan Ernerudh, Lena Jonasson
Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study
Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Stefania Bandinelli, Antimo Moretti, Giovanni Iolascon, Eleonora Sparvieri, Domiziano Tarantino, Luigi Ferrucci
Association between body fat distribution and B-lymphocyte subsets in peripheral blood
Pia Prechtl, Timo Schmitz, Nicole Pochert, Claudia Traidl-Hoffmann, Jakob Linseisen, Christa Meisinger, Dennis Freuer
Related factors of renal injury in primary Sjögren's syndrome
Nan Duan, Zhiyan Li, Yong Fan, Yaping Jiang, Haixia Li
Towards a better preclinical cancer model – human immune aging in humanized mice
Joel H. L. Tan, You Yi Hwang, Hui Xian Chin, Min Liu, Sue Yee Tan, Qingfeng Chen
Transcriptional characteristics and functional validation of three monocyte subsets during aging
Chen Wang, Yating Cheng, Boyu Li, Xueping Qiu, Hui Hu, Xiaokang Zhang, Zhibing Lu, Fang Zheng
Obesity drives adipose-derived stem cells into a senescent and dysfunctional phenotype associated with P38MAPK/NF-KB axis
L K Grun, R M Maurmann, J N Scholl, M E Fogaça, C R R Schmitz, C K Dias, J Gasparotto, A V Padoin, C C Mottin, F Klamt, F Figueiró, M H Jones, E C Filippi-Chiela, F C R Guma, F M Barbé-Tuana
Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients
Neriman Eren, Susanna Gerike, Berk Üsekes, Oliver Peters, Nicoleta-Carmen Cosma, Julian Hellmann-Regen
Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health
Margarete M. Karg, May Moorefield, Emma Hoffmann, Hannah Philipose, Drenushe Krasniqi, Cindy Hoppe, Daisy Y. Shu, Shintaro Shirahama, Bruce R. Ksander, Magali Saint-Geniez
Decoding the immune landscape following hip fracture in elderly patients: unveiling temporal dynamics through single-cell RNA sequencing
Yining Lu, Yang Luo, Qi Zhang, Wei Chen, Ning Zhang, Ling Wang, Yingze Zhang
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
Bernardo Abel Cedeno-Veloz, Lucía Lozano-Vicario, Fabricio Zambom-Ferraresi, Joaquín Fernández-Irigoyen, Enrique Santamaría, Alba Rodríguez-García, Roman Romero-Ortuno, Jaime Mondragon-Rubio, Javier Ruiz-Ruiz, Robinson Ramírez-Vélez, Mikel Izquierdo, Nicolás Martínez-Velilla
Bifidobacterium bifidum and Lactobacillus paracasei alleviate sarcopenia and cognitive impairment in aged mice by regulating gut microbiota-mediated AKT, NF-κB, and FOXO3a signaling pathways
Ji-Su Baek, Yoon-Jung Shin, Xiaoyang Ma, Hee-Seo Park, Yun-Ha Hwang, Dong-Hyun Kim
Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study
Yunus Kuijpers, H. Susan J. Picavet, Lia de Rond, Mary-lène de Zeeuw-Brouwer, Ryanne Rutkens, Esther Gijsbers, Irene Slits, Peter Engelfriet, Anne-Marie Buisman, W. M. Monique Verschuren
A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence
Meng He, Jürgen Borlak
TBX21, the Master regulator of the type 1 immune response, overexpresses in the leukocytes of peripheral blood in patients with late-onset Alzheimer’s disease
S. R. Fatemi Langroudi, M. Zeinaly, F. Ajamian
Correction: Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health
Margarete M. Karg, May Moorefield, Emma Hoffmann, Hannah Philipose, Drenushe Krasniqi, Cindy Hoppe, Daisy Y. Shu, Shintaro Shirahama, Bruce R. Ksander, Magali Saint-Geniez
Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome
Tomasz Kmiołek, Gabriela Filipowicz, Diana Bogucka, Anna Wajda, Adam Ejma-Multański, Barbara Stypińska, Ewa Modzelewska, Yana Kaliberda, Marcin Radkowski, Tomasz Targowski, Julia Wrona, Agnieszka Paradowska-Gorycka
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
Rubén Martín-Escolano, Erick Joan Vidal-Alcántara, Javier Crespo, Pablo Ryan, Luis Miguel Real, Juan Ignacio Lazo-Álvarez, Joaquín Cabezas-González, Juan Macías, María Teresa Arias-Loste, Guillermo Cuevas, Ana Virseda-Berdices, Veronica Briz, Salvador Resino, María Ángeles Jiménez-Sousa, Amanda Fernández-Rodríguez
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia
Hao Han, Yawei Zhao, Junda Du, Sushan Wang, Xuehan Yang, Weijie Li, Jiayi Song, Siwei Zhang, Ziyi Zhang, Yongfei Tan, Grant M. Hatch, Ming Zhang, Li Chen
Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly
Coralie Fonte, Pauline Jacob, Anne Vanet, Stéphanie Ghislin, Jean-Pol Frippiat
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions
Wen Deng, Caijiao Yi, Wei Pan, Jian Liu, Jinyan Qi, Juan Chen, Zengchao Zhou, Yiqin Duan, Xiangyan Ning, Jun Li, Changhua Ye, Zhongping Chen, Heping Xu
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway
Yahong Fu, Qiaowei Jia, Mengmeng Ren, Hengjie Bie, Xin Zhang, Qian Zhang, Shu He, Chengcheng Li, Hanxiao Zhou, Yanjun Wang, Xiongkang Gan, Zhengxian Tao, Xiumei Chen, Enzhi Jia
Toll-like receptor 4 (TLR4): new insight immune and aging
Hyo-Jin Kim, Hyemin Kim, Jeong-Hyung Lee, Cheol Hwangbo
Frailty is related to serum inflammageing markers: results from the VITAL study
Yannick van Sleen, Sudarshan A. Shetty, Marieke van der Heiden, Milou C. A. Venema, Nicolas Gutiérrez-Melo, Erik J. M. Toonen, Josine van Beek, Anne-Marie Buisman, Debbie van Baarle, Delphine Sauce
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective
Sean X. Leng, Albert C. Shaw
Impact of NAD+ metabolism on ovarian aging
Jinghui Liang, Feiling Huang, Zhaoqi Song, Ruiyi Tang, Peng Zhang, Rong Chen
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Juan Joseph Young, Hong-Jai Park, Minhyung Kim, Jennefer Par-Young, Hugh Bartlett, Hye Sun Kim, Serhan Unlu, Lais Osmani, Min Sun Shin, Richard Bucala, Christopher H. van Dyck, Heather Allore, Adam P. Mecca, Sungyong You, Insoo Kang
Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus
Shogo Ijima, Yuki Saito, Sena Yamamoto, Kentaro Nagaoka, Taiki Iwamoto, Arisa Kita, Maki Miyajima, Tsukasa Sato, Akihiro Miyazaki, Takako S. Chikenji
The effect of metformin on senescence of T lymphocytes
Jia Yang, Hai-Cheng Liu, Jian-Qing Zhang, Jian-Yong Zou, Xin Zhang, Wo-Ming Chen, Yong Gu, Hai Hong
IL-17A promotes the progression of Alzheimer’s disease in APP/PS1 mice
Min Cao, Jing Liu, Xiaomin Zhang, Yaqi Wang, Yuli Hou, Qiao Song, Yuting Cui, Yue Zhao, Peichang Wang
The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
Xiaomin Fu, Peng Qin, Fanghui Li, Huifang Zhu, Hongqin You, Yong Zhang, Benling Xu, Tiepeng Li, Fang Zhang, Lu Han, Lingdi Zhao, Baozhen Ma, Zibing Wang, Quanli Gao
Blood circulating bacterial DNA in hospitalized old COVID-19 patients
Robertina Giacconi, Patrizia D’Aquila, Maurizio Cardelli, Francesco Piacenza, Elisa Pierpaoli, Giada Sena, Mirko Di Rosa, Anna Rita Bonfigli, Roberta Galeazzi, Antonio Cherubini, Massimiliano Fedecostante, Riccardo Sarzani, Chiara Di Pentima, Piero Giordano, Roberto Antonicelli, Fabrizia Lattanzio, Giuseppe Passarino, Mauro Provinciali, Dina Bellizzi