Erschienen in:
01.12.2000 | Paper Report
PPAR? negatively regulates T cell function
verfasst von:
Andy Clark
Erschienen in:
Arthritis Research & Therapy
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Ausgabe 1/2000
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Excerpt
PPAR? is a member of the nuclear hormone receptor family of transcription factors. It is activated by naturally occurring ligands such as 15-deoxy-?12,14 prostaglandin J2 (15?-PGJ2), and by thiazolidinedione drugs such as troglitazone. Recent papers suggest that PPAR? is a negative regulator of macrophage function. This paper reports a novel function of PPAR?, the ability to block T cell activation and IL-2 expression. This function may involve negative regulation of the transcription factor NFATc, which plays a critical role in IL-2 gene expression and T cell activation. To investigate the function and mechanism of action of PPAR? in isolated T lymphocytes and in a T cell line. …