Erschienen in:
01.04.2013 | Research Article
Immunosuppressive effects of Euphorbia hirta in experimental animals
verfasst von:
Sheikh Fayaz Ahmad, Beenish Khan, Sarang Bani, Anpurna Kaul, Phalisteen Sultan, Sheikh Abid Ali, N. K. Satti, Saleh A. Bakheet, Sabry M. Attia, Khairy M. A. Zoheir, Adel R. A. Abd-Allah
Erschienen in:
Inflammopharmacology
|
Ausgabe 2/2013
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Abstract
Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, wounds, antipyretic, anti-inflammatory activities, etc. Therefore, we undertook to investigate their immunomodulatory effect on T lymphocytes (CD3+, CD4+ and CD8+ receptors) and Th1 cytokines (IL-2, TNF-α, IFN-γ) in a dose-dependent manner. E. hirta ethanol extract at 25, 50, 100 and 200 mg/kg doses was given orally for 7 days from the day of immunization. E. hirta maximum inhibition at 100 and 200 mg/kg p.o. was found to significantly block the production of the cell-mediated immune response, (CD3+, CD4+ and CD8+ receptors) and (IL-2, TNF-α, IFN-γ) and also prolongs graft rejection. E. hirta also showed a decrease of delayed hypersensitivity (DTH) response and dose-related decrease in the primary antibody response, respectively. Based on the data, it can be suggested that E. hirta is a potent and non-toxic immunosuppressor, which can be further explored for the development of potent immunosuppressor.