Skip to main content
main-content

01.06.2014 | Original Contribution | Ausgabe 4/2014

European Journal of Nutrition 4/2014

Impact of a functionalized olive oil extract on the uterus and the bone in a model of postmenopausal osteoporosis

Zeitschrift:
European Journal of Nutrition > Ausgabe 4/2014
Autoren:
Annekathrin Martina Keiler, Oliver Zierau, Ricardo Bernhardt, Dieter Scharnweber, Nikolaos Lemonakis, Aikaterini Termetzi, Leandros Skaltsounis, Günter Vollmer, Maria Halabalaki

Abstract

Purpose

The Mediterranean diet rich in fruits, vegetables and olive oil has been related to a lower osteoporosis incidence and accordingly to a reduced fracture risk. These observations might be mediated by the active constituents of extra virgin olive oil, and especially polyphenols. In the context of exploring the features of olive oil active constituents on postmenopausal osteoporosis, an extra virgin olive oil total polyphenolic fraction (TPF) was isolated and its effect on the bone loss attenuation was investigated.

Methods

Female Lewis rats were ovariectomized and fed a diet enriched with a total phenolic extract of extra virgin olive oil in a concentration of 800 mg/kg diet.

Results

Oleocanthal, one compound of the polyphenolic fraction, showed a higher relative estrogen receptor binding affinity to the ERα compared to the ERβ. While the TPF only slightly induced the uterine wet weight (490.7 ± 53.7 vs. 432.7 ± 23, p = 0.058), TPF regulated estrogen response genes in the uterus (progesterone receptor, antigen identified by monoclonal antibody Ki67, complement C3). Comparing the quantified bone parameters, the oral TPF substitution did not attenuate the ovariectomy-induced bone loss.

Conclusions

The administration of extra virgin olive oil polyphenols regulated uterine estrogen response marker genes in an E2-agonistic manner. The bone loss induced by estrogen ablation was not mitigated by treatment with the polyphenolic extract.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Für Ihren Erfolg in Klinik und Praxis - Die beste Hilfe in Ihrem Arbeitsalltag als Mediziner

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de.

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 4/2014

European Journal of Nutrition 4/2014 Zur Ausgabe

Neu im Fachgebiet Innere Medizin

22.01.2021 | Ernährung | Podcast | Onlineartikel

Vitaminmangel: Welche Vitamine im Blick haben?

Im Gespräch mit der Ernährungswissenschaftlerin Dr. Maria Wallert

19.01.2021 | COVID-19 | Nachrichten

Corona-Check mit Lavendelduft

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Innere Medizin und bleiben Sie gut informiert – ganz bequem per eMail.

© Springer Medizin 

Bildnachweise