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01.09.2014 | Original Article

Impact of a multi-nutrient diet on cognition, brain metabolism, hemodynamics, and plasticity in apoE4 carrier and apoE knockout mice

verfasst von: Diane Jansen, Valerio Zerbi, Carola I. F. Janssen, Daan van Rooij, Bastian Zinnhardt, Pieter J. Dederen, Alan J. Wright, Laus M. Broersen, Dieter Lütjohann, Arend Heerschap, Amanda J. Kiliaan

Erschienen in: Brain Structure and Function | Ausgabe 5/2014

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Abstract

Lipid metabolism and genetic background together strongly influence the development of both cardiovascular and neurodegenerative diseases like Alzheimer’s disease (AD). A non-pharmacological way to prevent the genotype-induced occurrence of these pathologies is given by dietary behavior. In the present study, we tested the effects of long-term consumption of a specific multi-nutrient diet in two models for atherosclerosis and vascular risk factors in AD: the apolipoprotein ε4 (apoE4) and the apoE knockout (apoE ko) mice. This specific multi-nutrient diet was developed to support neuronal membrane synthesis and was expected to contribute to the maintenance of vascular health. At 12 months of age, both genotypes showed behavioral changes compared to control mice and we found increased neurogenesis in apoE ko mice. The specific multi-nutrient diet decreased anxiety-related behavior in the open field, influenced sterol composition in serum and brain tissue, and increased the concentration of omega-3 fatty acids in the brain. Furthermore, we found that wild-type and apoE ko mice fed with this multi-nutrient diet showed locally increased cerebral blood volume and decreased hippocampal glutamate levels. Taken together, these data suggest that a specific dietary intervention has beneficial effects on early pathological consequences of hypercholesterolemia and vascular risk factors for AD.

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Titel: Impact of a multi-nutrient diet on cognition, brain metabolism, hemodynamics, and plasticity in apoE4 carrier and apoE knockout mice
verfasst von: Diane Jansen
Valerio Zerbi
Carola I. F. Janssen
Daan van Rooij
Bastian Zinnhardt
Pieter J. Dederen
Alan J. Wright
Laus M. Broersen
Dieter Lütjohann
Arend Heerschap
Amanda J. Kiliaan
Publikationsdatum: 01.09.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 5/2014
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-013-0606-7

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