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25.04.2019 | Sleep

Impact of Lung Function and SDB on Incident Myocardial Infarction and Heart Failure: A Community-based Study

verfasst von: Ruohan Li, Jingjing Zhang, Ya Gao, Jiamei Li, Bin Yan, Gang Wang

Erschienen in: Lung | Ausgabe 3/2019

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Abstract

Purpose

To investigate whether lung function, especially when complicated with SDB, has an increased risk for myocardial infarction (MI) and congestive heart failure (CHF).

Methods

A prospective study was performed within the Sleep Heart Health Study (SHHS). A total of 4161 individuals were followed up for an average of 10.91 years. Forced vital capacity (FVC), forced expiratory volume in one second (FEV₁) and the predicted value of FVC and FEV₁ were measured to evaluate lung function. The primary outcomes were the MI and CHF. Cox regression analysis was used to investigate the association between reduced lung function and the incidence of MI or CHF. In subgroup analysis, all the individuals were divided into Apnoea–Hypopnoea Index (AHI) < 5 subgroup and AHI ≥ 5 subgroup to explore the relationship.

Results

Lung function were inversely associated with the incidence of MI or CHF. The hazard ratio (HR) and 95% confidence interval (95% CI) for MI and CHF were 0.658 (0.543–0.797) and 0.792 (0.673–0.933) for every 1 L increase in FVC, 0.715 (0.567–0.902) and 0.738 (0.605–0.900) for every 1 L increase in FEV₁, 0.986 (0.979–0.993) and 0.989 (0.983–0.995) for every 1% increase in FEV₁/pre%, and 0.994 (0.988–0.999) and 0.991 (0.987–0.996) in FVC/pre%, respectively. In addition, the association of lung function with MI and CHF was more prominent in the subgroup with AHI ≥ 5.

Conclusions

Lung function may be associated with incident MI and CHF in this large community cohort of middle-aged and older adults, especially in those with SDB.

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Titel: Impact of Lung Function and SDB on Incident Myocardial Infarction and Heart Failure: A Community-based Study
verfasst von: Ruohan Li
Jingjing Zhang
Ya Gao
Jiamei Li
Bin Yan
Gang Wang
Publikationsdatum: 25.04.2019
Verlag: Springer US
Erschienen in: Lung / Ausgabe 3/2019
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-019-00229-0

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Impact of Lung Function and SDB on Incident Myocardial Infarction and Heart Failure: A Community-based Study

Abstract

Purpose

Methods

Results

Conclusions

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Abstract

Purpose

Methods

Results

Conclusions

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