nach oben

Erschienen in:

04.09.2017 | Maternal-Fetal Medicine

RETRACTED ARTICLE: Impact of maternal nutrition in hepatitis E infection in pregnancy

verfasst von: Ashok Kumar, Sheetal Sharma, Premashish Kar, Sarita Agarwal, Siddhartha Ramji, Syed Akhtar Husain, Sudha Prasad, Shashi Sharma

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 5/2017

Einloggen, um Zugang zu erhalten

Abstract

Background and aim

The basis of host response in hepatitis E virus (HEV)—related liver disease during pregnancy—is still unclear. The study aims to evaluate anthropometric parameters and biochemical nutritional parameters in hepatitis E infection during pregnancy and correlate it with severity of the disease.

Methods

A total of consecutive 267 pregnant women with jaundice were recruited. The jaundiced patients were classified as acute viral hepatitis (AVH) or acute liver failure (ALF). The study group included 144 pregnant women with HEV infection and 144 healthy asymptomatic age and gestational age-matched pregnant women as controls. Nutritional factors were evaluated on basis of anthropometric parameters and biochemical factors. Serum prealbumin and folate were assayed by ELISA kit.

Results

All nutritional parameters were significantly lower in pregnant women with HEV infection as compared with healthy pregnant controls. Some of the nutritional parameters significantly lower in ALF pregnant patients compared to AVH pregnant patients in HEV group. Linear regression analysis of the AVH group showed that serum total protein and mid-upper arm circumference (MUAC) were significant predictors for bilirubin, body mass index (BMI) could significantly predict viral load level, and total protein, prealbumin, folate, and tricep skin fold thickness (TSFT) could significantly predict prothrombin time. In ALF group, serum prealbumin could significantly predict bilirubin levels and MUAC could significantly predict prothrombin time.

Conclusion

Malnutrition might confer a higher predisposition for HEV infection during pregnancy and is associated with increased severity of disease in terms of occurrence of ALF.

Khuroo MS, Teli MR, Skidmore S, Soa MA, Khuroo MI (1981) Incidence and severity of viral hepatitis in pregnancy. Am J Med 70:252–255CrossRefPubMed

Kumar A, Beniwal M, Kar P, Sharma JB, Murthy NS (2004) Hepatitis E in pregnancy. Int J Gynaecol Obstet 85(3):240–244CrossRefPubMed

Jilani N, Das BC, Husain SA et al (2007) Hepatitis E virus infection and fulminant hepatic failure during pregnancy. J Gastroenterol Hepatol 22:676–682CrossRefPubMed

Stephen CA, Thame MM, Gray R et al (2002) Primary malnutrition. Can we always tell? West Indian Med J 51(3):148–152PubMed

Black R (2003) Micronutrient deficiency: an underlying cause of morbidity and mortality. Bull World Health Organ 81(2):79PubMedPubMedCentral

Krawczynski K (1993) Hepatitis E. Hepatology 17:932–941CrossRefPubMed

Chandra S, Chandra RK (1986) Nutrition, immune response, and outcome. Prog Food Nutr Sci 10:1–65PubMed

Stapleton PP, Fujita J, Murphy EM, Naama HA, Daly JM (2001) The influence of restricted calorie intake on peritoneal macrophage function. Nutrition 17(1):41–45CrossRefPubMed

Menta PL, Correia MI, Vidigal PV, Silva LD, Teixeira R (2015) Nutrition status of patients with chronic hepatitis B or C. Nutr Clin Pract 30(2):290–296CrossRefPubMed

10.

Sánchez López AM, Moreno-Torres Herrera R, Pérez de la Cruz AJ, Orduña Espinosa R, Medina T, López Martínez C (2005) Malnutrition prevalence in patients admitted to a rehabilitation and orthopedic surgery hospital. Nutr Hosp 20(2):121–130PubMed

11.

Teiusanu A, Andrei M, Arbanas T, Nicolaie T, Diculescu M (2012) Nutritional status in cirrhotic patients. Maedica (Buchar) 7(4):284–289

12.

Meng QH, Yu HW, Li J et al (2010) Inadequate nutritional intake and protein-energy malnutrition involved in acute and chronic viral hepatitis Chinese patients especially in cirrhosis patients. Hepatogastroenterology 57(101):845–851PubMed

13.

Dai FH, Zeng WQ, Jiang CY (2012) Assessment of the factors associated with insulin resistance in patients with chronic hepatitis B infection. Zhonghua Gan Zang Bing Za Zhi 20(7):517–521PubMed

14.

Patra S, Kumar A, Trivedi SS, Puri M, Sarin SK (2007) Maternal and fetal outcomes in pregnant women with acute hepatitis E virus infection. Ann Intern Med 538(147):28–33CrossRef

15.

Bose PD, Das BC, Kumar A, Gondal R, Kumar D, Kar P (2011) High viral load and deregulation of the progesterone receptor signaling pathway: association with hepatitis E-related poor pregnancy outcome. J Hepatol 54:1107–1113CrossRefPubMed

16.

Kar P, Jilani N, Husain SA, Pasha ST, Anand R, Rai A, Das BC (2008) Does hepatitis E viral load and genotypes influence the final outcome of acute liver failure during pregnancy? Am J Gastroenterol 103:2495–2501CrossRefPubMed

17.

Smedile A, Carcil FP, Verma G et al (1982) Inference of delta infection on the severity of hepatitis B. Lancet 2:945–947CrossRefPubMed

18.

Tandon BN, Bernauau J, O’Grady J et al (1999) Recommendations of the International Association for the Study of the Liver subcommittee on nomenclature of acute and subacute liver failure. J Gastroenterol Hepatol 14:403–404CrossRefPubMed

19.

Mahajan BK, Gupta MC (1995) Textbook of preventive and social medicine, 3rd edn. Jaypee Brothers, Delhi, pp 134–135

20.

National Nutrition Monitoring Bureau. Special Report on elderly and Adolescents: Diet and nutritional status. NNMB Technical Report No. 20 National Institute of Nutrition, Hyderabad

21.

Fatmah (2010) Validation of predicted height model based in arm span, Knee height and sitting height in Indonesian elderly people. J Clin Me Res 295:67–73

22.

Rabe B, Thamrin MH, Gross R, Solomons NW, Schultink W (1996) Body mass index of the elderly derived from height and from armspan. Asia Pac J Clin Nutr 5:79–83PubMed

23.

Madan K, Gopalkrishna V, Kar P, Sharma JK, Das UP, Das BC (1998) Detection of hepatitis C and E virus genomes in sera of patients with acute viral hepatitis and fulminant hepatitis by their simultaneous amplification in PCR. J Gastroenterol Hepatol 13:125–130CrossRefPubMed

24.

Jaiswal SPB, Jain AK, Naik G, Soni N, Chitnis DS (2001) Viral hepatitis during pregnancy. Int Gynecol Obstet 72:103–108CrossRef

25.

Singh S, Mohanty A, Joshi YK, Dwivedi SN, Deka D (2001) Outcome of hepatitis E virus infection in Indian pregnant women admitted to a tertiary care hospital. Indian J Med Res 113:35–39PubMed

26.

Scrimshaw NS, Taylor CE, Gordon JE (1968) Interactions of nutrition and infection. Monogr Ser World Health Organ 57:3–329PubMed

27.

Saravanabalaji S, Tripathy AS, Dhoot RR, Chadha MS, Kakrani AL, Arankalle VA (2009) Viral load, antibody titers and recombinant open reading frame 2 protein-induced TH1/TH2 cytokines and cellular immune responses in self-limiting and fulminant hepatitis E. Intervirology 52(2):78–85CrossRefPubMed

28.

Pal R, Aggarwal R, Naik SR, Das V, Das S, Naik S (2005) Immunological alterations in pregnant women with acute hepatitis E. J Gastroenterol Hepatol 20(7):1094–1101CrossRefPubMed

29.

Devoto G, Gallo F, Marchello C (2006) Prealbumin serum concentrations as a useful tool in the assessment of malnutrition in hospitalized patients. Clin Chem 52(12):2281–2285CrossRefPubMed

30.

Mears E (1996) Outcomes of continuous process improvement of a nutritional care program incorporating serum prealbumin measurements. Nutrition 12(7–8):479–484CrossRefPubMed

31.

Schaible UE, Kaufmann SH (2007) Malnutrition and infection: complex mechanisms and global impacts. PLoS Medicine 4(5):e115CrossRefPubMedPubMedCentral

32.

Woodward B (1998) Protein, calories, and immune defenses. Nutr Rev 56(1 Pt 2):S84–S92PubMed

33.

Powell-Tuck J, Hennessy EM (2003) A comparison of mid upper arm circumference, body mass index and weight loss as indices of undernutrition in acutely hospitalized patients. Clin Nutr 22(3):307–312CrossRefPubMed

34.

Collins S (1996) Using middle upper arm circumference to assess severe adult malnutrition during famine. JAMA 276(5):391–395CrossRefPubMed

35.

Bose K (2001) The interaction of waist-hip ratio and conicity index with subcutaneous adiposity in two ethnic groups: native British and migrant Pakistani men. Anthropol Anz 59(3):275–282CrossRefPubMed

36.

Gowda C, Compher C, Amorosa VK, Lo Re V 3rd (2014) Association between chronic hepatitis C virus infection and low muscle mass in US adults. J Viral Hepat 21(12):938–943CrossRefPubMedPubMedCentral

37.

Huang L, Li J, Yan JJ, Liu CF, Wu MC, Yan YQ (2012) Prealbumin is predictive for postoperative liver insufficiency in patients undergoing liver resection. World J Gastroenterol 18(47):7021–7025CrossRefPubMedPubMedCentral

Titel: RETRACTED ARTICLE: Impact of maternal nutrition in hepatitis E infection in pregnancy
verfasst von: Ashok Kumar
Sheetal Sharma
Premashish Kar
Sarita Agarwal
Siddhartha Ramji
Syed Akhtar Husain
Sudha Prasad
Shashi Sharma
Publikationsdatum: 04.09.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 5/2017
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-017-4501-y

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

RETRACTED ARTICLE: Impact of maternal nutrition in hepatitis E infection in pregnancy