nach oben

Erschienen in:

25.08.2020 | Original Paper

Impact of sub-foveal choroidal thickness on clinical features and long-term clinical outcomes in polypoidal choroidal vasculopathy

verfasst von: Ramesh Venkatesh, Santosh Gopi Krishna Gadde, Arpitha Pereira, Vivek Singh, Sajjan Sangai, Akhila Sridharan, Bharathi Bavaharan, Nimesh Jain, Naresh Kumar Yadav

Erschienen in: International Ophthalmology | Ausgabe 1/2021

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To study the clinical features and long-term clinical outcomes in polypoidal choroidal vasculopathy (PCV) in eyes with different sub-foveal choroidal thickness (SFCT).

Methods

In this retrospective, observational comparative study, treatment-naïve eyes diagnosed with PCV using the ‘EVEREST-2’ study criteria were included. The eyes were divided into three groups of thin, medium and thick choroids, based on the SFCT data of total study eyes. Demographic, clinical, imaging features and treatment outcomes between the 3 groups were compared.

Results

Sixty-three eyes in 63 patients were included. Right eye was involved in 39 (61%) cases and left eye in 24 (39%) cases. Mean age was 68.3 ± 6.82 years (range 54–85 years). Mean SFCT was 274 µm (median = 269 µm), and one standard deviation was 79.2 µm. Totally, 11, 43 and 9 eyes were included in the thin, medium and thick choroid groups, respectively. The mean SFCT was 161 ± 24.1 µm, 275 ± 39.6 µm and 412 ± 26.2 µm in the thin, medium and thick choroid groups, respectively. There was no statistically significant difference in the clinical and imaging features and treatment outcomes between eyes with thin, medium and thick SFCT.

Conclusion

Eyes with PCV can have a choroid of varying thicknesses. Clinical, imaging and treatment responses were similar between the three sub-foveal choroidal thickness groups in this study. In future, more studies are required to evaluate the role of the choroidal thickness and its relationship to treatment in PCV.

Cheung CMG, Lee WK, Koizumi H et al (2019) Pachychoroid disease. Eye (Lond) 33:14–33. https://doi.org/10.1038/s41433-018-0158-4CrossRef

Lee WK, Baek J, Dansingani KK et al (2016) Choroidal morphology in eyes with polypoidal choroidal vasculopathy and normal or subnormal subfoveal choroidal thickness. Retina (Philadelphia, Pa) 36(Suppl 1):S73–S82. https://doi.org/10.1097/IAE.0000000000001346CrossRef

Ciardella AP, Donsoff IM, Huang SJ et al (2004) Polypoidal choroidal vasculopathy. Surv Ophthalmol 49:25–37. https://doi.org/10.1016/j.survophthal.2003.10.007CrossRefPubMed

Coscas G, Yamashiro K, Coscas F et al (2014) Comparison of exudative age-related macular degeneration subtypes in Japanese and French Patients: multicenter diagnosis with multimodal imaging. Am J Ophthalmol 158:309–318.e2. https://doi.org/10.1016/j.ajo.2014.05.004CrossRefPubMed

Yang LH, Jonas JB, Wei WB (2013) Optical coherence tomographic enhanced depth imaging of polypoidal choroidal vasculopathy. Retina (Philadelphia, Pa) 33:1584–1589. https://doi.org/10.1097/IAE.0b013e318285cbb3CrossRef

Nakai S, Honda S, Miki A et al (2017) Comparison of the 12-month outcomes of intravitreal ranibizumab between two angiographic subtypes of polypoidal choroidal vasculopathy. Ophthalmologica 237:123–127. https://doi.org/10.1159/000455273CrossRefPubMed

Tan CSH, Ngo WK, Lim LW, Lim TH (2014) A novel classification of the vascular patterns of polypoidal choroidal vasculopathy and its relation to clinical outcomes. Br J Ophthalmol 98:1528–1533. https://doi.org/10.1136/bjophthalmol-2014-305059CrossRefPubMed

Chaikitmongkol V, Kong J, Khunsongkiet P et al (2019) Sensitivity and specificity of potential diagnostic features detected using fundus photography, optical coherence tomography, and fluorescein angiography for polypoidal choroidal vasculopathy. JAMA Ophthalmol 137:661–667. https://doi.org/10.1001/jamaophthalmol.2019.0565CrossRefPubMedPubMedCentral

Huang C-H, Yeh P-T, Hsieh Y-T et al (2019) Characterizing branching vascular network morphology in polypoidal choroidal vasculopathy by optical coherence tomography angiography. Sci Rep 9:595. https://doi.org/10.1038/s41598-018-37384-yCrossRefPubMedPubMedCentral

10.

Chung SE, Kang SW, Lee JH, Kim YT (2011) Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration. Ophthalmology 118:840–845. https://doi.org/10.1016/j.ophtha.2010.09.012CrossRefPubMed

11.

Takahashi Y, Koizumi H, Hasegawa T et al (2018) Comparison of subfoveal choroidal structures in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. Jpn J Ophthalmol 62:576–583. https://doi.org/10.1007/s10384-018-0615-4CrossRefPubMed

12.

Kong M, Kim SM, Ham D-I (2017) Comparison of clinical features and 3-month treatment response among three different choroidal thickness groups in polypoidal choroidal vasculopathy. PLoS ONE 12:e0184058. https://doi.org/10.1371/journal.pone.0184058CrossRefPubMedPubMedCentral

13.

Chang Y-C, Cheng C-K (2019) Difference between pachychoroid and nonpachychoroid polypoidal choroidal vasculopathy and their response to anti-vascular endothelial growth factor therapy. Retina (Philadelphia, Pa). https://doi.org/10.1097/IAE.0000000000002583CrossRef

14.

Rayess N, Rahimy E, Ying G-S et al (2015) Baseline choroidal thickness as a predictor for response to anti-vascular endothelial growth factor therapy in diabetic macular edema. Am J Ophthalmol 159(85–91):e1–e3. https://doi.org/10.1016/j.ajo.2014.09.033CrossRef

15.

Shin JY, Kwon KY, Byeon SH (2015) Association between choroidal thickness and the response to intravitreal ranibizumab injection in age-related macular degeneration. Acta Ophthalmol 93:524–532. https://doi.org/10.1111/aos.12653CrossRefPubMed

16.

Ho CPS, Lai TYY (2018) Current management strategy of polypoidal choroidal vasculopathy. Indian J Ophthalmol 66:1727–1735. https://doi.org/10.4103/ijo.IJO_975_18CrossRefPubMedPubMedCentral

17.

Fenner BJ, Ting DSW, Tan ACS et al (2019) Real-world treatment outcomes of age-related macular degeneration and polypoidal choroidal vasculopathy in asians. Ophthalmol Retina. https://doi.org/10.1016/j.oret.2019.10.019CrossRefPubMed

18.

Yang J, Yuan M, Xia S, Chen Y (2019) Six-year real-world outcomes of antivascular endothelial growth factor monotherapy and combination therapy for various subtypes of polypoidal choroidal vasculopathy. J Ophthalmol 2019:1609717. https://doi.org/10.1155/2019/1609717CrossRefPubMedPubMedCentral

19.

Uyama M, Wada M, Nagai Y et al (2002) Polypoidal choroidal vasculopathy: natural history. Am J Ophthalmol 133:639–648. https://doi.org/10.1016/s0002-9394(02)01404-6CrossRefPubMed

20.

Tan CS, Ngo WK, Chen JP et al (2015) EVEREST study report 2: imaging and grading protocol, and baseline characteristics of a randomised controlled trial of polypoidal choroidal vasculopathy. Br J Ophthalmol 99:624–628. https://doi.org/10.1136/bjophthalmol-2014-305674CrossRefPubMedPubMedCentral

21.

Wakatsuki Y, Shinojima A, Kawamura A, Yuzawa M (2015) Correlation of aging and segmental choroidal thickness measurement using swept source optical coherence tomography in healthy eyes. PLoS ONE 10:e0144156. https://doi.org/10.1371/journal.pone.0144156CrossRefPubMedPubMedCentral

22.

Dansingani KK, Balaratnasingam C, Klufas MA et al (2015) Optical coherence tomography angiography of shallow irregular pigment epithelial detachments in pachychoroid spectrum disease. Am J Ophthalmol 160:1243–1254.e2. https://doi.org/10.1016/j.ajo.2015.08.028CrossRefPubMed

Titel: Impact of sub-foveal choroidal thickness on clinical features and long-term clinical outcomes in polypoidal choroidal vasculopathy
verfasst von: Ramesh Venkatesh
Santosh Gopi Krishna Gadde
Arpitha Pereira
Vivek Singh
Sajjan Sangai
Akhila Sridharan
Bharathi Bavaharan
Nimesh Jain
Naresh Kumar Yadav
Publikationsdatum: 25.08.2020
Verlag: Springer Netherlands
Erschienen in: International Ophthalmology / Ausgabe 1/2021
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-020-01555-6

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Impact of sub-foveal choroidal thickness on clinical features and long-term clinical outcomes in polypoidal choroidal vasculopathy

Abstract

Purpose

Methods

Results

Conclusion

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2021

The efficacy of gonioscopy-assisted transluminal trabeculectomy combined with phacoemulsification

Pentacam corneal densitometry-guided treatment of adenoviral corneal subepithelial infiltrates: a comparative study between transepithelial phototherapeutic keratectomy and topical tacrolimus

Comparison of vessel density in macular and peripapillary regions between primary open-angle glaucoma and pseudoexfoliation glaucoma using OCTA

Molecular and clinical characterization of Thai patients with achromatopsia: identification of three novel disease-associated variants in the CNGA3 and CNGB3 genes

Correction of pseudophakic presbyopia using Lasik with aspheric ablation profiles and a micro-monovision protocol

Comparison of reading performance with low add bifocal and extended depth of focus intraocular lenses implanted with mini-monovision

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde