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Clinical Rheumatology

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28.12.2015 | Original Article

Impact of the polymorphism in vitamin D receptor gene BsmI and the risk of systemic lupus erythematosus: an updated meta-analysis

verfasst von: Weiping Hu, Guodong Niu, Yong Lin, Xiaoqing Chen, Ling Lin

Erschienen in: Clinical Rheumatology | Ausgabe 4/2016

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Abstract

The etiology of system lupus erythematosus (SLE) still remains unclear, and vitamin D is associated with immune response. Although a few studies are conducted to investigate the association between polymorphism in vitamin D receptor (VDR) genes and SLE risk, their results are conflicting. Following the guideline of PRISMA, we conducted a systematic search and meta-analysis of the BsmI polymorphism rs1544410 and the risk of SLE. The pooled odds ratios (OR) and its 95 % confidential interval (CI) were calculated by using Stata Version 10 with dominant and recessive model and allele analyses. Nine studies were included in our meta-analysis with a total of 1247 SLE cases and 1687 controls. No significant association was found in both models in the overall population. Only Bb + BB genotypes showed a significantly elevated SLE risk in Asian subgroup with an OR of 3.26 (95 % CI = 1.30–8.17) while no significance was observed in Caucasian population. Notably, B allele significantly increased the SLE risk among Asian population with an OR of 2.29 (95 % CI = 1.14–4.61). No positive findings were reported in Caucasian population and in the overall analysis. In Asian population, Bb + BB genotype and B allele can significantly increase the SLE risk.

Choi J, Kim ST, Craft J (2012) The pathogenesis of systemic lupus erythematosus—an update. Curr Opin Immunol 24(6):651–657CrossRefPubMedPubMedCentral

Lisnevskaia L, Murphy G, Isenberg D (2014) Systemic lupus erythematosus. Lancet 384(9957):1878–1888CrossRefPubMed

D’Cruz DP, Khamashta MA, Hughes GR (2007) Systemic lupus erythematosus. Lancet 369(9561):587–596CrossRefPubMed

Zandman-Goddard G, Solomon M, Rosman Z et al (2012) Environment and lupus-related diseases. Lupus 21(3):241–250CrossRefPubMed

Harley JB, Kelly JA, Kaufman KM (2006) Unraveling the genetics of systemic lupus erythematosus. Springer Semin Immunopathol 28(2):119–130CrossRefPubMed

Bogdanos DP, Smyk DS, Rigopoulou EI et al (2012) Twin studies in autoimmune disease: genetics, gender and environment. J Autoimmun 38(2–3):J156–J169CrossRefPubMed

Hristova M, Dourmishev L, Kamenarska Z et al (2013) Role of the promoter polymorphism IL-6 -174G/C in dermatomyositis and systemic lupus erythematosus. Biomed Res Int 2013:315365CrossRefPubMedPubMedCentral

Webb R, Merrill JT, Kelly JA et al (2009) A polymorphism within IL21R confers risk for systemic lupus erythematosus. Arthritis Rheum 60(8):2402–2407CrossRefPubMedPubMedCentral

Warchoł T, Mostowska A, Lianeri M et al (2012) XRCC1 Arg399Gln gene polymorphism and the risk of systemic lupus erythematosus in the Polish population. DNA Cell Biol 31(1):50–56CrossRefPubMedPubMedCentral

10.

Hawn TR, Wu H, Grossman JM et al (2005) A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. Proc Natl Acad Sci U S A 102(30):10593–10597CrossRefPubMedPubMedCentral

11.

Takahashi R, Tsutsumi A, Ohtani K et al (2005) Association of mannose binding lectin (MBL) gene polymorphism and serum MBL concentration with characteristics and progression of systemic lupus erythematosus. Ann Rheum Dis 64(2):311–314CrossRefPubMedPubMedCentral

12.

Moher D, Liberati A, Tetzlaff J et al (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8(5):336–341CrossRefPubMed

13.

Ozaki Y, Nomura S, Nagahama M et al (2000) Vitamin-D receptor genotype and renal disorder in Japanese patients with systemic lupus erythematosus. Nephron 85(1):86–91CrossRefPubMed

14.

Huang CM, Wu MC, Wu JY et al (2002) Association of vitamin D receptor gene BsmI polymorphisms in Chinese patients with systemic lupus erythematosus. Lupus 11(1):31–34CrossRefPubMed

15.

Sakulpipatsin W, Verasertniyom O, Nantiruj K et al (2006) Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus. Arthritis Res Ther 8(2):R48CrossRefPubMedPubMedCentral

16.

Abbasi M, Rezaieyazdi Z, Afshari JT et al (2010) Lack of association of vitamin D receptor gene BsmI polymorphisms in patients with systemic lupus erythematosus. Rheumatol Int 30(11):1537–1539CrossRefPubMed

17.

Luo XY, Yang MH, Wu FX et al (2012) Vitamin D receptor gene BsmI polymorphism B allele, but not BB genotype, is associated with systemic lupus erythematosus in a Han Chinese population. Lupus 21(1):53–59CrossRefPubMed

18.

Monticielo OA, Brenol JC, Chies JA et al (2012) The role of BsmI and FokI vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D in Brazilian patients with systemic lupus erythematosus. Lupus 21(1):43–52CrossRefPubMed

19.

Kaleta B, Bogaczewicz J, Robak E et al (2013) Vitamin D receptor gene BsmI polymorphism in polish patients with systemic lupus erythematosus. ISRN Endocrinol 2013:427818CrossRefPubMedPubMedCentral

20.

Mostowska A, Lianeri M, Wudarski M et al (2013) Vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus. Mol Biol Rep 40(2):803–810CrossRefPubMedPubMedCentral

21.

Carvalho C, Marinho A, Leal B et al (2015) Association between vitamin D receptor (VDR) gene polymorphisms and systemic lupus erythematosus in Portuguese patients. Lupus 24(8):846–853CrossRefPubMed

22.

Holick MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80(6 Suppl):1678S–1688SPubMed

23.

Grant WB (2006) Epidemiology of disease risks in relation to vitamin D insufficiency. Prog Biophys Mol Biol 92(1):65–79CrossRefPubMed

24.

Lemire JM, Ince A, Takashima M (1992) 1,25-Dihydroxyvitamin D₃ attenuates the expression of experimental murine lupus of MRL/l mice. Autoimmunity 12(2):143–148CrossRefPubMed

25.

Ritterhouse LL, Crowe SR, Niewold TB et al (2011) Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus. Ann Rheum Dis 70(9):1569–1574CrossRefPubMedPubMedCentral

26.

O’Regan S, Chesney RW, Hamstra A et al (1979) Reduced serum 1,25-(OH)2 vitamin D₃ levels in prednisone-treated adolescents with systemic lupus erythematosus. Acta Paediatr Scand 68(1):109–111CrossRefPubMed

27.

Hamza RT, Awwad KS, Ali MK et al (2011) Reduced serum concentrations of 25-hydroxy vitamin D in Egyptian patients with systemic lupus erythematosus: relation to disease activity. Med Sci Monit 17(12):CR711–CR718CrossRefPubMedPubMedCentral

28.

McGhie TK, DeCeulaer K, Walters CA et al (2014) Vitamin D levels in Jamaican patients with systemic lupus erythematosus. Lupus 23(10):1092–1096CrossRefPubMed

29.

Garf KE, Marzouk H, Farag Y et al (2015) Vitamin D status in Egyptian patients with juvenile-onset systemic lupus erythematosus. Rheumatol Int 35(9):1535–1540CrossRefPubMed

30.

Yap KS, Northcott M, Hoi AB et al (2015) Association of low vitamin D with high disease activity in an Australian systemic lupus erythematosus cohort. Lupus Sci Med 2(1):e000064CrossRefPubMedPubMedCentral

31.

Morrison NA, Qi JC, Tokita A et al (1994) Prediction of bone density from vitamin D receptor alleles. Nature 367(6460):284–287CrossRefPubMed

32.

Alroy I, Towers TL, Freedman LP (1995) Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Mol Cell Biol 15(10):5789–5799CrossRefPubMedPubMedCentral

33.

Lemire JM, Adams JS, Kermani-Arab V et al (1985) 1,25-Dihydroxyvitamin D₃ suppresses human T helper/inducer lymphocyte activity in vitro. J Immunol 134(5):3032–3035PubMed

Titel: Impact of the polymorphism in vitamin D receptor gene BsmI and the risk of systemic lupus erythematosus: an updated meta-analysis
verfasst von: Weiping Hu
Guodong Niu
Yong Lin
Xiaoqing Chen
Ling Lin
Publikationsdatum: 28.12.2015
Verlag: Springer London
Erschienen in: Clinical Rheumatology / Ausgabe 4/2016
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-015-3157-x

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