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21.05.2019 | Review

Implications of grape extract and its nanoformulated bioactive agent resveratrol against skin disorders

verfasst von: Samaneh Soleymani, Amin Iranpanah, Fariba Najafi, Tarun Belwal, Sudipta Ramola, Zahra Abbasabadi, Saeideh Momtaz, Mohammad Hosein Farzaei

Erschienen in: Archives of Dermatological Research | Ausgabe 8/2019

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Abstract

The grape seed extract (GSE) and its main active polyphenol, resveratrol (RES), have shown considerable antioxidant activities, besides possessed protective and therapeutic effects against various skin complications. This paper discusses the favorable effects of RES, GSE and their nanoformulations for dermatological approaches, with specific emphasis on clinical interventions. In this manner, electronic databases including PubMed, Science Direct and Google Scholar were searched. Data were collected from 1980 up to February 2019. The search terms included “Vitis vinifera”, “grape”, “resveratrol”, “skin”, “dermatology”, and “nanoformulation”. To increase the skin permeability of GSE and RES, several innovative nanoformulation such as liposomes, niosomes, solid–lipid nanoparticles, nanostructured lipid carriers, and lipid-core nanocapsule has been evaluated. According to our extensive searches, both RES and GSE have beneficial impacts on skin disorders such as chloasma, acne vulgaris, skin aging, as well as wound and facial redness. More clinical studies with nanoformulation approaches are recommended to achieve conclusive outcomes regarding the efficacy of RES and GSE in the management of skin diseases.

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Titel: Implications of grape extract and its nanoformulated bioactive agent resveratrol against skin disorders
verfasst von: Samaneh Soleymani
Amin Iranpanah
Fariba Najafi
Tarun Belwal
Sudipta Ramola
Zahra Abbasabadi
Saeideh Momtaz
Mohammad Hosein Farzaei
Publikationsdatum: 21.05.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Dermatological Research / Ausgabe 8/2019
Print ISSN: 0340-3696
Elektronische ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-019-01930-z

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