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Erschienen in: Modern Rheumatology 1/2011

01.02.2011 | Original Article

Incidence of falls and fear of falling in Japanese patients with rheumatoid arthritis

verfasst von: Kiyotaka Yamagiwa, Setsu Iijima, Takefumi Furuya, Tetsuo Ikai, Eisuke Inoue, Atsuo Taniguchi, Shigeki Momohara, Hisashi Yamanaka

Erschienen in: Modern Rheumatology | Ausgabe 1/2011

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Abstract

The objective of this study is to determine the incidence of falls and fear of falling by gender and age in Japanese patients with rheumatoid arthritis (RA). Among the Japanese patients who participated in a single-institute-based prospective observational cohort study of patients with RA, namely the Institute of Rheumatology Rheumatoid Arthritis, 765 men (median age 63 years) and 4,231 women (median age 60 years) with RA responded to questions related to falls. Eight percent of men and 11% of women reported one or more falls during the previous 6 months. At least one fall and multiple falls were significantly more frequent in men (p < 0.05) and in women (p < 0.001) with RA over age 65 and age 75 years, respectively, although there was no significant linear increase in risk with age. Sixteen percent of men and 22% of women reported fear of falling. More men over age 65 tended to report fear of falling than those under age 65 (p < 0.001), although the incidence of women with fear of falling increased with advancing age. Japanese patients with RA over age 65 and age 75 appeared to have a high risk of at least one fall and multiple falls, respectively.
Literatur
1.
Zurück zum Zitat Haugeberg G, Uhlig T, Falch JA, Halse JI, Kvien TK. Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis: results from 394 patients in the Oslo County Rheumatoid Arthritis register. Arthritis Rheum. 2000;43:522–30.CrossRefPubMed Haugeberg G, Uhlig T, Falch JA, Halse JI, Kvien TK. Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis: results from 394 patients in the Oslo County Rheumatoid Arthritis register. Arthritis Rheum. 2000;43:522–30.CrossRefPubMed
2.
Zurück zum Zitat Shibuya K, Hagino H, Morio Y, Teshima R. Cross-sectional and longitudinal study of osteoporosis in patients with rheumatoid arthritis. Clin Rheumatol. 2002;21:150–8.CrossRefPubMed Shibuya K, Hagino H, Morio Y, Teshima R. Cross-sectional and longitudinal study of osteoporosis in patients with rheumatoid arthritis. Clin Rheumatol. 2002;21:150–8.CrossRefPubMed
3.
Zurück zum Zitat Cooper C, Coupland C, Mitchell M. Rheumatoid arthritis, corticosteroid therapy and hip fracture. Ann Rheum Dis. 1995;54:49–52.CrossRefPubMed Cooper C, Coupland C, Mitchell M. Rheumatoid arthritis, corticosteroid therapy and hip fracture. Ann Rheum Dis. 1995;54:49–52.CrossRefPubMed
4.
Zurück zum Zitat Hooyman JR, Melton LJ 3rd, Nelson AM, O’Fallon WM, Riggs BL. Fractures after rheumatoid arthritis. A population-based study. Arthritis Rheum. 1984;27:1353–61.CrossRefPubMed Hooyman JR, Melton LJ 3rd, Nelson AM, O’Fallon WM, Riggs BL. Fractures after rheumatoid arthritis. A population-based study. Arthritis Rheum. 1984;27:1353–61.CrossRefPubMed
5.
Zurück zum Zitat Huusko TM, Korpela M, Karppi P, Avikainen V, Kautiainen H, Sulkava R. Threefold increased risk of hip fractures with rheumatoid arthritis in Central Finland. Ann Rheum Dis. 2001;60:521–2.CrossRefPubMed Huusko TM, Korpela M, Karppi P, Avikainen V, Kautiainen H, Sulkava R. Threefold increased risk of hip fractures with rheumatoid arthritis in Central Finland. Ann Rheum Dis. 2001;60:521–2.CrossRefPubMed
6.
Zurück zum Zitat Orstavik RE, Haugeberg G, Mowinckel P, Hoiseth A, Uhlig T, Falch JA, et al. Vertebral deformities in rheumatoid arthritis: a comparison with population-based controls. Arch Intern Med. 2004;164:420–5.CrossRefPubMed Orstavik RE, Haugeberg G, Mowinckel P, Hoiseth A, Uhlig T, Falch JA, et al. Vertebral deformities in rheumatoid arthritis: a comparison with population-based controls. Arch Intern Med. 2004;164:420–5.CrossRefPubMed
7.
Zurück zum Zitat Kaz Kaz H, Johnson D, Kerry S, Chinappen U, Tweed K, Patel S. Fall-related risk factors and osteoporosis in women with rheumatoid arthritis. Rheumatology (Oxford). 2004;43:1267–71.CrossRef Kaz Kaz H, Johnson D, Kerry S, Chinappen U, Tweed K, Patel S. Fall-related risk factors and osteoporosis in women with rheumatoid arthritis. Rheumatology (Oxford). 2004;43:1267–71.CrossRef
8.
Zurück zum Zitat Yamanaka H, Tohma S. Potential impact of observational cohort studies in Japan on rheumatoid arthritis research and practice. Mod Rheumatol. 2006;16:75–6.CrossRefPubMed Yamanaka H, Tohma S. Potential impact of observational cohort studies in Japan on rheumatoid arthritis research and practice. Mod Rheumatol. 2006;16:75–6.CrossRefPubMed
9.
Zurück zum Zitat Furuya T, Kotake S, Inoue E, Nanke Y, Yago T, Kobashigawa T, et al. Risk factors associated with incident clinical vertebral and nonvertebral fractures in Japanese women with rheumatoid arthritis: a prospective 54-month observational study. J Rheumatol. 2007;34:303–10.PubMed Furuya T, Kotake S, Inoue E, Nanke Y, Yago T, Kobashigawa T, et al. Risk factors associated with incident clinical vertebral and nonvertebral fractures in Japanese women with rheumatoid arthritis: a prospective 54-month observational study. J Rheumatol. 2007;34:303–10.PubMed
10.
Zurück zum Zitat Furuya T, Urano T, Ikari K, Kotake S, Inoue S, Hara M, et al. A1330V polymorphism of low-density lipoprotein receptor-related protein 5 gene and self-reported incident fractures in Japanese female patients with rheumatoid arthritis. Mod Rheumatol. 2009;19:140–6.CrossRefPubMed Furuya T, Urano T, Ikari K, Kotake S, Inoue S, Hara M, et al. A1330V polymorphism of low-density lipoprotein receptor-related protein 5 gene and self-reported incident fractures in Japanese female patients with rheumatoid arthritis. Mod Rheumatol. 2009;19:140–6.CrossRefPubMed
11.
Zurück zum Zitat Urano W, Furuya T, Inoue E, Taniguchi A, Urano T, Kotake S, et al. Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients. J Bone Miner Metab. 2009;27:574–83.CrossRefPubMed Urano W, Furuya T, Inoue E, Taniguchi A, Urano T, Kotake S, et al. Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients. J Bone Miner Metab. 2009;27:574–83.CrossRefPubMed
12.
Zurück zum Zitat Furuya T, Kotake S, Inoue E, Nanke Y, Yago T, Hara M, et al. Risk factors associated with incident fractures in Japanese men with rheumatoid arthritis: a prospective observational cohort study. J Bone Miner Metab. 2008;26:499–505.PubMed Furuya T, Kotake S, Inoue E, Nanke Y, Yago T, Hara M, et al. Risk factors associated with incident fractures in Japanese men with rheumatoid arthritis: a prospective observational cohort study. J Bone Miner Metab. 2008;26:499–505.PubMed
13.
Zurück zum Zitat Nampei A, Hashimoto J, Koyanagi J, Ono T, Hashimoto H, Tsumaki N, et al. Characteristics of fracture and related factors in patients with rheumatoid arthritis. Mod Rheumatol. 2008;18:170–6.CrossRefPubMed Nampei A, Hashimoto J, Koyanagi J, Ono T, Hashimoto H, Tsumaki N, et al. Characteristics of fracture and related factors in patients with rheumatoid arthritis. Mod Rheumatol. 2008;18:170–6.CrossRefPubMed
14.
Zurück zum Zitat Furuya T, Yamagiwa K, Ikai T, Inoue E, Taniguchi A, Momohara S, et al. Associated factors for falls and fear of falling in Japanese patients with rheumatoid arthritis. Clin Rheumatol. 2009;28:1325–30.CrossRefPubMed Furuya T, Yamagiwa K, Ikai T, Inoue E, Taniguchi A, Momohara S, et al. Associated factors for falls and fear of falling in Japanese patients with rheumatoid arthritis. Clin Rheumatol. 2009;28:1325–30.CrossRefPubMed
15.
Zurück zum Zitat Guideline for the prevention of falls in older persons. American Geriatrics Society, British Geriatrics Society, and American Academy of Orthopaedic Surgeons Panel on Falls Prevention. J Am Geriatr Soc. 2001;49:664–72. Guideline for the prevention of falls in older persons. American Geriatrics Society, British Geriatrics Society, and American Academy of Orthopaedic Surgeons Panel on Falls Prevention. J Am Geriatr Soc. 2001;49:664–72.
16.
Zurück zum Zitat Oswald AE, Pye SR, O’Neill TW, Bunn D, Gaffney K, Marshall T, et al. Prevalence and associated factors for falls in women with established inflammatory polyarthritis. J Rheumatol. 2006;33:690–4.PubMed Oswald AE, Pye SR, O’Neill TW, Bunn D, Gaffney K, Marshall T, et al. Prevalence and associated factors for falls in women with established inflammatory polyarthritis. J Rheumatol. 2006;33:690–4.PubMed
17.
Zurück zum Zitat Armstrong C, Swarbrick CM, Pye SR, O’Neill TW. Occurrence and risk factors for falls in rheumatoid arthritis. Ann Rheum Dis. 2005;64:1602–4.CrossRefPubMed Armstrong C, Swarbrick CM, Pye SR, O’Neill TW. Occurrence and risk factors for falls in rheumatoid arthritis. Ann Rheum Dis. 2005;64:1602–4.CrossRefPubMed
18.
Zurück zum Zitat Hayashibara M, Hagino H, Katagiri H, Okano T, Okada J, Teshima R. Incidence and risk factors of falling in ambulatory patients with rheumatoid arthritis: a prospective 1-year study. Osteoporos Int. 2010. doi:10.1007/s00198-009-1150-4. Hayashibara M, Hagino H, Katagiri H, Okano T, Okada J, Teshima R. Incidence and risk factors of falling in ambulatory patients with rheumatoid arthritis: a prospective 1-year study. Osteoporos Int. 2010. doi:10.​1007/​s00198-009-1150-4.
19.
Zurück zum Zitat Jamison M, Neuberger GB, Miller PA. Correlates of falls and fear of falling among adults with rheumatoid arthritis. Arthritis Rheum. 2003;49:673–80.CrossRefPubMed Jamison M, Neuberger GB, Miller PA. Correlates of falls and fear of falling among adults with rheumatoid arthritis. Arthritis Rheum. 2003;49:673–80.CrossRefPubMed
20.
Zurück zum Zitat Smulders E, Schreven C, Weerdesteyn V, van den Hoogen FH, Laan R, Van Lankveld W. Fall incidence and fall risk factors in people with rheumatoid arthritis. Ann Rheum Dis. 2009;68:1795–6.CrossRefPubMed Smulders E, Schreven C, Weerdesteyn V, van den Hoogen FH, Laan R, Van Lankveld W. Fall incidence and fall risk factors in people with rheumatoid arthritis. Ann Rheum Dis. 2009;68:1795–6.CrossRefPubMed
21.
Zurück zum Zitat Fessel KD, Nevitt MC. Correlates of fear of falling and activity limitation among persons with rheumatoid arthritis. Arthritis Care Res. 1997;10:222–8.CrossRefPubMed Fessel KD, Nevitt MC. Correlates of fear of falling and activity limitation among persons with rheumatoid arthritis. Arthritis Care Res. 1997;10:222–8.CrossRefPubMed
22.
Zurück zum Zitat Iikuni N, Sato E, Hoshi M, Inoue E, Taniguchi A, Hara M, et al. The influence of sex on patients with rheumatoid arthritis in a large observational cohort. J Rheumatol. 2009;36:508–11.CrossRefPubMed Iikuni N, Sato E, Hoshi M, Inoue E, Taniguchi A, Hara M, et al. The influence of sex on patients with rheumatoid arthritis in a large observational cohort. J Rheumatol. 2009;36:508–11.CrossRefPubMed
23.
Zurück zum Zitat Matsuda Y, Singh G, Yamanaka H, Tanaka E, Urano W, Taniguchi A, et al. Validation of a Japanese version of the Stanford Health Assessment Questionnaire in 3,763 patients with rheumatoid arthritis. Arthritis Rheum. 2003;49:784–8.CrossRefPubMed Matsuda Y, Singh G, Yamanaka H, Tanaka E, Urano W, Taniguchi A, et al. Validation of a Japanese version of the Stanford Health Assessment Questionnaire in 3,763 patients with rheumatoid arthritis. Arthritis Rheum. 2003;49:784–8.CrossRefPubMed
24.
Zurück zum Zitat Momohara S, Inoue E, Ikari K, Kawamura K, Tsukahara S, Iwamoto T, et al. Decrease in orthopaedic operations, including total joint replacements, in patients with rheumatoid arthritis between 2001 and 2007: data from Japanese outpatients in a single institute-based large observational cohort (IORRA). Ann Rheum Dis. 2010;69:312–3.CrossRefPubMed Momohara S, Inoue E, Ikari K, Kawamura K, Tsukahara S, Iwamoto T, et al. Decrease in orthopaedic operations, including total joint replacements, in patients with rheumatoid arthritis between 2001 and 2007: data from Japanese outpatients in a single institute-based large observational cohort (IORRA). Ann Rheum Dis. 2010;69:312–3.CrossRefPubMed
25.
Zurück zum Zitat Momohara S, Inoue E, Ikari K, Tsukahara S, Kawamura K, Toki H, et al. Risk factors for wrist surgery in rheumatoid arthritis. Clin Rheumatol. 2008;27:1387–91.CrossRefPubMed Momohara S, Inoue E, Ikari K, Tsukahara S, Kawamura K, Toki H, et al. Risk factors for wrist surgery in rheumatoid arthritis. Clin Rheumatol. 2008;27:1387–91.CrossRefPubMed
26.
Zurück zum Zitat Nakajima A, Inoue E, Tanaka E, Singh G, Sato E, Hoshi D, et al. Mortality and cause of death in Japanese patients with rheumatoid arthritis based on a large observational cohort, IORRA. Scand J Rheumatol. 2010. doi: 10.1007/s00296-010-1524-0. Nakajima A, Inoue E, Tanaka E, Singh G, Sato E, Hoshi D, et al. Mortality and cause of death in Japanese patients with rheumatoid arthritis based on a large observational cohort, IORRA. Scand J Rheumatol. 2010. doi: 10.​1007/​s00296-010-1524-0.
27.
Zurück zum Zitat Okamoto H, Koizumi K, Kamitsuji S, Inoue E, Hara M, Tomatsu T, et al. Beneficial action of statins in patients with rheumatoid arthritis in a large observational cohort. J Rheumatol. 2007;34:964–8.PubMed Okamoto H, Koizumi K, Kamitsuji S, Inoue E, Hara M, Tomatsu T, et al. Beneficial action of statins in patients with rheumatoid arthritis in a large observational cohort. J Rheumatol. 2007;34:964–8.PubMed
28.
Zurück zum Zitat Shidara K, Hoshi D, Inoue E, Yamada T, Nakajima A, Taniguchi A, et al. Incidence of and risk factors for interstitial pneumonia in patients with rheumatoid arthritis in a large Japanese observational cohort, IORRA. Mod Rheumatol. 2010;20:280–6.CrossRefPubMed Shidara K, Hoshi D, Inoue E, Yamada T, Nakajima A, Taniguchi A, et al. Incidence of and risk factors for interstitial pneumonia in patients with rheumatoid arthritis in a large Japanese observational cohort, IORRA. Mod Rheumatol. 2010;20:280–6.CrossRefPubMed
29.
Zurück zum Zitat Tanaka E, Inoue E, Mannalithara A, Bennett M, Kamitsuji S, Taniguchi A, et al. Medical care costs of patients with rheumatoid arthritis during the prebiologics period in Japan: a large prospective observational cohort study. Mod Rheumatol. 2010;20:46–53.CrossRefPubMed Tanaka E, Inoue E, Mannalithara A, Bennett M, Kamitsuji S, Taniguchi A, et al. Medical care costs of patients with rheumatoid arthritis during the prebiologics period in Japan: a large prospective observational cohort study. Mod Rheumatol. 2010;20:46–53.CrossRefPubMed
30.
Zurück zum Zitat Tanaka E, Mannalithara A, Inoue E, Hara M, Tomatsu T, Kamatani N, et al. Efficient management of rheumatoid arthritis significantly reduces long-term functional disability. Ann Rheum Dis. 2008;67:1153–8.CrossRefPubMed Tanaka E, Mannalithara A, Inoue E, Hara M, Tomatsu T, Kamatani N, et al. Efficient management of rheumatoid arthritis significantly reduces long-term functional disability. Ann Rheum Dis. 2008;67:1153–8.CrossRefPubMed
31.
Zurück zum Zitat Yamada T, Nakajima A, Inoue E, Tanaka E, Hara M, Tomatsu T, et al. Increased risk of tuberculosis in patients with rheumatoid arthritis in Japan. Ann Rheum Dis. 2006;65:1661–3.CrossRefPubMed Yamada T, Nakajima A, Inoue E, Tanaka E, Hara M, Tomatsu T, et al. Increased risk of tuberculosis in patients with rheumatoid arthritis in Japan. Ann Rheum Dis. 2006;65:1661–3.CrossRefPubMed
32.
Zurück zum Zitat Yamada T, Nakajima A, Inoue E, Tanaka E, Taniguchi A, Momohara S, et al. Incidence of malignancy in Japanese patients with rheumatoid arthritis. Rheumatol Int. 2010. doi:10.1007/s00296-010-1524-0. Yamada T, Nakajima A, Inoue E, Tanaka E, Taniguchi A, Momohara S, et al. Incidence of malignancy in Japanese patients with rheumatoid arthritis. Rheumatol Int. 2010. doi:10.​1007/​s00296-010-1524-0.
33.
Zurück zum Zitat Prevoo ML, van’t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995;38:44–8. Prevoo ML, van’t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995;38:44–8.
34.
Zurück zum Zitat Aoyagi K, Ross PD, Davis JW, Wasnich RD, Hayashi T, Takemoto T. Falls among community-dwelling elderly in Japan. J Bone Miner Res. 1998;13:1468–74.CrossRefPubMed Aoyagi K, Ross PD, Davis JW, Wasnich RD, Hayashi T, Takemoto T. Falls among community-dwelling elderly in Japan. J Bone Miner Res. 1998;13:1468–74.CrossRefPubMed
35.
Zurück zum Zitat Smulders E, Schreven C, van Lankveld W, Duysens J, Weerdesteyn V. Obstacle avoidance in persons with rheumatoid arthritis walking on a treadmill. Clin Exp Rheumatol. 2009;27:779–85.PubMed Smulders E, Schreven C, van Lankveld W, Duysens J, Weerdesteyn V. Obstacle avoidance in persons with rheumatoid arthritis walking on a treadmill. Clin Exp Rheumatol. 2009;27:779–85.PubMed
36.
Zurück zum Zitat de Kam D, Smulders E, Weerdesteyn V, Smits-Engelsman BC. Exercise interventions to reduce fall-related fractures and their risk factors in individuals with low bone density: a systematic review of randomized controlled trials. Osteoporos Int. 2009;20:2111–25.CrossRefPubMed de Kam D, Smulders E, Weerdesteyn V, Smits-Engelsman BC. Exercise interventions to reduce fall-related fractures and their risk factors in individuals with low bone density: a systematic review of randomized controlled trials. Osteoporos Int. 2009;20:2111–25.CrossRefPubMed
37.
Zurück zum Zitat Cummings SR, Nevitt MC, Kidd S. Forgetting falls. The limited accuracy of recall of falls in the elderly. J Am Geriatr Soc. 1988;36:613–6.PubMed Cummings SR, Nevitt MC, Kidd S. Forgetting falls. The limited accuracy of recall of falls in the elderly. J Am Geriatr Soc. 1988;36:613–6.PubMed
38.
Zurück zum Zitat Ganz DA, Higashi T, Rubenstein LZ. Monitoring falls in cohort studies of community-dwelling older people: effect of the recall interval. J Am Geriatr Soc. 2005;53:2190–4.CrossRefPubMed Ganz DA, Higashi T, Rubenstein LZ. Monitoring falls in cohort studies of community-dwelling older people: effect of the recall interval. J Am Geriatr Soc. 2005;53:2190–4.CrossRefPubMed
39.
Zurück zum Zitat Friedman SM, Munoz B, West SK, Rubin GS, Fried LP. Falls and fear of falling: which comes first? A longitudinal prediction model suggests strategies for primary and secondary prevention. J Am Geriatr Soc. 2002;50:1329–35.CrossRefPubMed Friedman SM, Munoz B, West SK, Rubin GS, Fried LP. Falls and fear of falling: which comes first? A longitudinal prediction model suggests strategies for primary and secondary prevention. J Am Geriatr Soc. 2002;50:1329–35.CrossRefPubMed
40.
Zurück zum Zitat Chen JS, March LM, Schwarz J, Zochling J, Makaroff J, Sitoh YY, et al. A multivariate regression model predicted falls in residents living in intermediate hostel care. J Clin Epidemiol. 2005;58:503–8.CrossRefPubMed Chen JS, March LM, Schwarz J, Zochling J, Makaroff J, Sitoh YY, et al. A multivariate regression model predicted falls in residents living in intermediate hostel care. J Clin Epidemiol. 2005;58:503–8.CrossRefPubMed
41.
Zurück zum Zitat Hill KD, Moore KJ, Dorevitch MI, Day LM. Effectiveness of falls clinics: an evaluation of outcomes and client adherence to recommended interventions. J Am Geriatr Soc. 2008;56:600–8.CrossRefPubMed Hill KD, Moore KJ, Dorevitch MI, Day LM. Effectiveness of falls clinics: an evaluation of outcomes and client adherence to recommended interventions. J Am Geriatr Soc. 2008;56:600–8.CrossRefPubMed
Metadaten
Titel
Incidence of falls and fear of falling in Japanese patients with rheumatoid arthritis
verfasst von
Kiyotaka Yamagiwa
Setsu Iijima
Takefumi Furuya
Tetsuo Ikai
Eisuke Inoue
Atsuo Taniguchi
Shigeki Momohara
Hisashi Yamanaka
Publikationsdatum
01.02.2011
Verlag
Springer Japan
Erschienen in
Modern Rheumatology / Ausgabe 1/2011
Print ISSN: 1439-7595
Elektronische ISSN: 1439-7609
DOI
https://doi.org/10.1007/s10165-010-0351-1

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