Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays.
IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro-maintained mast cells stimulated with IL-17A. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling.
Roos AB, Sanden C, Mori M, Bjermer L, Stampfli MR, Erjefalt JS: IL-17A Is Elevated in End-Stage Chronic Obstructive Pulmonary Disease and Contributes to Cigarette Smoke-induced Lymphoid Neogenesis. Am J Respir Crit Care Med. 2015;191(11):1232-41.
Andersen HB, Holm M, Hetland TE, Dahl C, Junker S, Schiøtz PO, Hoffmann HJ. Comparison of short term in vitro cultured human mast cells from different progenitors — Peripheral blood-derived progenitors generate highly mature and functional mast cells. Journal of Immunological Methods. 2008;336(2):166–74. CrossRefPubMed
- Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF
Abraham B. Roos
Harpreet K. Gura
Hans Jürgen Hoffmann
Jonas S. Erjefält
Martin R. Stampfli
- BioMed Central
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