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Neurological Sciences

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16.07.2020 | Original Article

Increased rapid eye movement density in Chinese patients with Parkinson’s disease and RBD

verfasst von: Jun Zhu, Liyu Lu, Min Zhong, Xu Jiang, Zhuang Wu, Jingde Dong, Yang Pan, Li Zhang

Erschienen in: Neurological Sciences | Ausgabe 3/2021

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Abstract

Objective

Impaired rapid eye movement sleep is common among patients with Parkinson’s disease (PD). However, information on rapid eye movement density (REM) among PD patients is currently lacking. The current study sought to characterize REM density in PD patients and to examine the associations between REM density sleep parameters and clinical manifestations.

Participants and methods

We retrospectively recruited 172 PD patients. All participants were assessed with a two-night polysomnography, and REM density was calculated. Clinical assessments were completed in PD patients before polysomnography.

Results

Rapid eye movement sleep behavior disorder (RBD) was observed in 93 patients (54.1%). The disease duration, UPDRS part III score, Hoehn and Yahr (H-Y) stage, and HAMA, HAMD, PDQ-39 scores, and REM density in the Parkinson’s disease patients with rapid eye movement sleep behavior disorder (RBD) were significantly higher than in the patients without RBD (P < 0.05). However, NREM sleep stage 3 time (N3 time) and percentage of N3 time of total sleep time (N3%) were significantly lower in the RBD patients than in the patients without RBD (P < 0.05). The forward binary logistic regression model showed that REM density, UPDRS-III score, and N3 sleep time were associated with RBD in the PD patients.

Conclusions

Our results confirm the high prevalence of RBD in patients with PD. Increased REM density was the main risk factor of RBD.

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Titel: Increased rapid eye movement density in Chinese patients with Parkinson’s disease and RBD
verfasst von: Jun Zhu
Liyu Lu
Min Zhong
Xu Jiang
Zhuang Wu
Jingde Dong
Yang Pan
Li Zhang
Publikationsdatum: 16.07.2020
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 3/2021
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04597-x

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