Skip to main content
Erschienen in: Journal of Medical Ultrasonics 3/2020

18.04.2020 | Original Article–Breast & Thyroid

Incremental diagnostic value of shear wave elastography combined with contrast-enhanced ultrasound in TI-RADS category 4a and 4b nodules

verfasst von: Shao-Ting Huang, Bo Zhang, Hong-Ling Yin, Bo Li, Jin-Tang Liao, Yi-Bin Wang

Erschienen in: Journal of Medical Ultrasonics | Ausgabe 3/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To evaluate the diagnostic value of shear wave elastography (SWE) combined with contrast-enhanced ultrasonography (CEUS) in diagnosing thyroid imaging reporting and data system (TI-RADS) category 4a and 4b nodules.

Methods

TI-RADS, SWE, and CEUS features of 71 thyroid nodules (23 benign, 48 malignant) confirmed by postoperative pathological results were retrospectively analyzed. The diagnostic efficiency of each single method and that of a combination of three methods were compared.

Results

The sensitivity and specificity in diagnosing thyroid nodules were 70.83% and 65.22% for TI-RADS, 68.75% and 91.30% for SWE, 77.08% and 78.26% for CEUS, and 91.67% and 95.65% for TI-RADS + SWE + CEUS, respectively. The area under the curve for TI-RADS, SWE, CEUS, and TI-RADS + SWE + CEUS in diagnosing thyroid nodules were 0.680, 0.839, 0.799, and 0.937, respectively. A significant difference was observed between a combination of the three methods and any of them alone (p < 0.05).

Conclusion

Combining SWE and CEUS improves the differential diagnosis of TI-RADS category 4a and 4b nodules.
Literatur
1.
Zurück zum Zitat Durante C, Grani G, Lamartina L, et al. The diagnosis and management of thyroid nodules: a review. JAMA. 2018;319:914–24.CrossRef Durante C, Grani G, Lamartina L, et al. The diagnosis and management of thyroid nodules: a review. JAMA. 2018;319:914–24.CrossRef
2.
Zurück zum Zitat Xia F, Jiang B, Chen Y, et al. Prediction of novel target genes and pathways involved in tall cell variant papillary thyroid carcinoma. Medicine (Baltimore). 2018;97:e13802.CrossRef Xia F, Jiang B, Chen Y, et al. Prediction of novel target genes and pathways involved in tall cell variant papillary thyroid carcinoma. Medicine (Baltimore). 2018;97:e13802.CrossRef
3.
Zurück zum Zitat Zeng RC, Zhang W, Gao EL, et al. Number of central lymph node metastasis for predicting lateral lymph node metastasis in papillary thyroid microcarcinoma. Head Neck. 2014;36:101–6.CrossRef Zeng RC, Zhang W, Gao EL, et al. Number of central lymph node metastasis for predicting lateral lymph node metastasis in papillary thyroid microcarcinoma. Head Neck. 2014;36:101–6.CrossRef
4.
Zurück zum Zitat Hoang JK, Middleton WD, Farjat AE, et al. Reduction in thyroid nodule biopsies and improved accuracy with American College of Radiology Thyroid Imaging Reporting and Data System. Radiology. 2018;287:185–93.CrossRef Hoang JK, Middleton WD, Farjat AE, et al. Reduction in thyroid nodule biopsies and improved accuracy with American College of Radiology Thyroid Imaging Reporting and Data System. Radiology. 2018;287:185–93.CrossRef
5.
Zurück zum Zitat Park AY, Son EJ, Han K, et al. Shear wave elastography of thyroid nodules for the prediction of malignancy in a large scale study. Eur J Radiol. 2015;84:407–12.CrossRef Park AY, Son EJ, Han K, et al. Shear wave elastography of thyroid nodules for the prediction of malignancy in a large scale study. Eur J Radiol. 2015;84:407–12.CrossRef
6.
Zurück zum Zitat Horvath E, Majlis S, Rossi R, et al. An ultrasonogram reporting system for thyroid nodules stratifying cancer risk for clinical management. J Clin Endocrinol Metab. 2009;94:1748–51.CrossRef Horvath E, Majlis S, Rossi R, et al. An ultrasonogram reporting system for thyroid nodules stratifying cancer risk for clinical management. J Clin Endocrinol Metab. 2009;94:1748–51.CrossRef
7.
Zurück zum Zitat Park JY, Lee HJ, Jang HW, et al. A proposal for a thyroid imaging reporting and data system for ultrasound features of thyroid carcinoma. Thyroid. 2009;19:1257–64.CrossRef Park JY, Lee HJ, Jang HW, et al. A proposal for a thyroid imaging reporting and data system for ultrasound features of thyroid carcinoma. Thyroid. 2009;19:1257–64.CrossRef
8.
Zurück zum Zitat Kwak JY, Han KH, Yoon JH, et al. Thyroid imaging reporting and data system for US features of nodules: a step in establishing better stratification of cancer risk. Radiology. 2011;260:892–9.CrossRef Kwak JY, Han KH, Yoon JH, et al. Thyroid imaging reporting and data system for US features of nodules: a step in establishing better stratification of cancer risk. Radiology. 2011;260:892–9.CrossRef
9.
Zurück zum Zitat Zhang Y, Zhou P, Tian SM, et al. Usefulness of combined use of contrast-enhanced ultrasound and TI-RADS classification for the differentiation of benign from malignant lesions of thyroid nodules. Eur Radiol. 2017;27:1527–36.CrossRef Zhang Y, Zhou P, Tian SM, et al. Usefulness of combined use of contrast-enhanced ultrasound and TI-RADS classification for the differentiation of benign from malignant lesions of thyroid nodules. Eur Radiol. 2017;27:1527–36.CrossRef
10.
Zurück zum Zitat Migda B, Migda M, Migda MS, et al. Use of the Kwak Thyroid Image Reporting and Data System (K-TIRADS) in differential diagnosis of thyroid nodules: systematic review and meta-analysis. Eur Radiol. 2018;28:2380–8.CrossRef Migda B, Migda M, Migda MS, et al. Use of the Kwak Thyroid Image Reporting and Data System (K-TIRADS) in differential diagnosis of thyroid nodules: systematic review and meta-analysis. Eur Radiol. 2018;28:2380–8.CrossRef
11.
Zurück zum Zitat Hu L, He N, Ye L, et al. Evaluation of the stiffness of tissues surrounding thyroid nodules with shear wave elastography. J Ultrasound Med. 2018;37:2251–61.CrossRef Hu L, He N, Ye L, et al. Evaluation of the stiffness of tissues surrounding thyroid nodules with shear wave elastography. J Ultrasound Med. 2018;37:2251–61.CrossRef
12.
Zurück zum Zitat Clevert DA, Sommer WH, Helck A, et al. Duplex and contrast enhanced ultrasound (CEUS) in evaluation of in-stent restenosis after carotid stenting. Clin Hemorheol Microcirc. 2011;48:199–208.CrossRef Clevert DA, Sommer WH, Helck A, et al. Duplex and contrast enhanced ultrasound (CEUS) in evaluation of in-stent restenosis after carotid stenting. Clin Hemorheol Microcirc. 2011;48:199–208.CrossRef
13.
Zurück zum Zitat Liu Y, Wu H, Zhou Q, et al. Diagnostic value of conventional ultrasonography combined with contrast-enhanced ultrasonography in Thyroid Imaging Reporting and Data System (TI-RADS) 3 and 4 thyroid micronodules. Med Sci Monit. 2016;22:3086–94.CrossRef Liu Y, Wu H, Zhou Q, et al. Diagnostic value of conventional ultrasonography combined with contrast-enhanced ultrasonography in Thyroid Imaging Reporting and Data System (TI-RADS) 3 and 4 thyroid micronodules. Med Sci Monit. 2016;22:3086–94.CrossRef
14.
Zurück zum Zitat Yu D, Han Y, Chen T. Contrast-enhanced ultrasound for differentiation of benign and malignant thyroid lesions: meta-analysis. Otolaryngol Head Neck Surg. 2014;151:909–15.CrossRef Yu D, Han Y, Chen T. Contrast-enhanced ultrasound for differentiation of benign and malignant thyroid lesions: meta-analysis. Otolaryngol Head Neck Surg. 2014;151:909–15.CrossRef
15.
Zurück zum Zitat Deng J, Zhou P, Tian SM, et al. Comparison of diagnostic efficacy of contrast-enhanced ultrasound, acoustic radiation force impulse imaging, and their combined use in differentiating focal solid thyroid nodules. PLoS ONE. 2014;9:e90674.CrossRef Deng J, Zhou P, Tian SM, et al. Comparison of diagnostic efficacy of contrast-enhanced ultrasound, acoustic radiation force impulse imaging, and their combined use in differentiating focal solid thyroid nodules. PLoS ONE. 2014;9:e90674.CrossRef
16.
Zurück zum Zitat Ko SY, Kim EK, Sung JM, et al. Diagnostic performance of ultrasound and ultrasound elastography with respect to physician experience. Ultrasound Med Biol. 2014;40:854–63.CrossRef Ko SY, Kim EK, Sung JM, et al. Diagnostic performance of ultrasound and ultrasound elastography with respect to physician experience. Ultrasound Med Biol. 2014;40:854–63.CrossRef
17.
Zurück zum Zitat Unlütürk U, Erdoğan MF, Demir O, et al. Ultrasound elastography is not superior to grayscale ultrasound in predicting malignancy in thyroid nodules. Thyroid. 2012;22:1031–8.CrossRef Unlütürk U, Erdoğan MF, Demir O, et al. Ultrasound elastography is not superior to grayscale ultrasound in predicting malignancy in thyroid nodules. Thyroid. 2012;22:1031–8.CrossRef
18.
Zurück zum Zitat Chen M, Zhang KQ, Xu YF, et al. Shear wave elastography and contrast-enhanced ultrasonography in the diagnosis of thyroid malignant nodules. Mol Clin Oncol. 2016;5(6):724–30.CrossRef Chen M, Zhang KQ, Xu YF, et al. Shear wave elastography and contrast-enhanced ultrasonography in the diagnosis of thyroid malignant nodules. Mol Clin Oncol. 2016;5(6):724–30.CrossRef
19.
Zurück zum Zitat Jebreel A, England J, Bedford K, et al. Vascular endothelial growth factor (VEGF), VEGF receptors expression and microvascular density in benign and malignant thyroid diseases. Int J Exp Pathol. 2007;88:271–7.CrossRef Jebreel A, England J, Bedford K, et al. Vascular endothelial growth factor (VEGF), VEGF receptors expression and microvascular density in benign and malignant thyroid diseases. Int J Exp Pathol. 2007;88:271–7.CrossRef
20.
Zurück zum Zitat Ma JJ, Ding H, Xu BH, et al. Diagnostic performances of various gray-scale, color Doppler, and contrast-enhanced ultrasonography findings in predicting malignant thyroid nodules. Thyroid. 2014;24:355–63.CrossRef Ma JJ, Ding H, Xu BH, et al. Diagnostic performances of various gray-scale, color Doppler, and contrast-enhanced ultrasonography findings in predicting malignant thyroid nodules. Thyroid. 2014;24:355–63.CrossRef
21.
Zurück zum Zitat Zhang Y, Luo YK, Zhang MB, et al. Diagnostic accuracy of contrast-enhanced ultrasound enhancement patterns for thyroid nodules. Med Sci Monit. 2016;22:4755–64.CrossRef Zhang Y, Luo YK, Zhang MB, et al. Diagnostic accuracy of contrast-enhanced ultrasound enhancement patterns for thyroid nodules. Med Sci Monit. 2016;22:4755–64.CrossRef
22.
Zurück zum Zitat Wang Y, Lei KR, He YP, et al. Malignancy risk stratification of thyroid nodules: comparisons of four ultrasound thyroid imaging reporting and data systems in surgically resected nodules. Sci Rep. 2017;7:11560.CrossRef Wang Y, Lei KR, He YP, et al. Malignancy risk stratification of thyroid nodules: comparisons of four ultrasound thyroid imaging reporting and data systems in surgically resected nodules. Sci Rep. 2017;7:11560.CrossRef
23.
Zurück zum Zitat Schenke S, Zimny M. Combination of sonoelastography and TIRADS for the diagnostic assessment of thyroid nodules. Ultrasound Med Biol. 2018;44:575–83.CrossRef Schenke S, Zimny M. Combination of sonoelastography and TIRADS for the diagnostic assessment of thyroid nodules. Ultrasound Med Biol. 2018;44:575–83.CrossRef
24.
Zurück zum Zitat Liu Z, Jing H, Han X, et al. Shear wave elastography combined with the thyroid imaging reporting and data system for malignancy risk stratification in thyroid nodules. Oncotarget. 2017;8:43406–16.CrossRef Liu Z, Jing H, Han X, et al. Shear wave elastography combined with the thyroid imaging reporting and data system for malignancy risk stratification in thyroid nodules. Oncotarget. 2017;8:43406–16.CrossRef
25.
Zurück zum Zitat Kim HJ, Kwak MK, Choi IH, et al. Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity. Korean J Intern Med. 2019;34:850–7.CrossRef Kim HJ, Kwak MK, Choi IH, et al. Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity. Korean J Intern Med. 2019;34:850–7.CrossRef
26.
Zurück zum Zitat Duan SB, Yu J, Li X, et al. Diagnostic value of two-dimensional shear wave elastography in papillary thyroid microcarcinoma. Onco Targets Ther. 2016;9:1311–7.PubMedPubMedCentral Duan SB, Yu J, Li X, et al. Diagnostic value of two-dimensional shear wave elastography in papillary thyroid microcarcinoma. Onco Targets Ther. 2016;9:1311–7.PubMedPubMedCentral
27.
Zurück zum Zitat Liu B, Liang J, Zheng Y, et al. Two-dimensional shear wave elastography as promising diagnostic tool for predicting malignant thyroid nodules: a prospective single-centre experience. Eur Radiol. 2015;25:624–34.CrossRef Liu B, Liang J, Zheng Y, et al. Two-dimensional shear wave elastography as promising diagnostic tool for predicting malignant thyroid nodules: a prospective single-centre experience. Eur Radiol. 2015;25:624–34.CrossRef
28.
Zurück zum Zitat Chang N, Zhang X, Wan W, et al. The preciseness in diagnosing thyroid malignant nodules using shear-wave elastography. Med Sci Monit. 2018;24:671–7.CrossRef Chang N, Zhang X, Wan W, et al. The preciseness in diagnosing thyroid malignant nodules using shear-wave elastography. Med Sci Monit. 2018;24:671–7.CrossRef
29.
Zurück zum Zitat Du J, Li FH, Fang H, et al. Correlation of real-time gray scale contrast-enhanced ultrasonography with microvessel density and vascular endothelial growth factor expression for assessment of angiogenesis in breast lesions. J Ultrasound Med. 2008;27:821–31.CrossRef Du J, Li FH, Fang H, et al. Correlation of real-time gray scale contrast-enhanced ultrasonography with microvessel density and vascular endothelial growth factor expression for assessment of angiogenesis in breast lesions. J Ultrasound Med. 2008;27:821–31.CrossRef
30.
Zurück zum Zitat Halpern EJ, Ramey JR, Strup SE, et al. Detection of prostate carcinoma with contrast-enhanced sonography using intermittent harmonic imaging. Cancer. 2005;104:2373–83.CrossRef Halpern EJ, Ramey JR, Strup SE, et al. Detection of prostate carcinoma with contrast-enhanced sonography using intermittent harmonic imaging. Cancer. 2005;104:2373–83.CrossRef
31.
Zurück zum Zitat Peng Q, Niu C, Zhang Q, et al. Mummified thyroid nodules: conventional and contrast-enhanced ultrasound features. J Ultrasound Med. 2019;38:441–52.CrossRef Peng Q, Niu C, Zhang Q, et al. Mummified thyroid nodules: conventional and contrast-enhanced ultrasound features. J Ultrasound Med. 2019;38:441–52.CrossRef
32.
Zurück zum Zitat Zhou X, Zhou P, Hu Z, et al. Diagnostic efficiency of quantitative contrast-enhanced ultrasound indicators for discriminating benign from malignant solid thyroid nodules. J Ultrasound Med. 2018;37:425–37.CrossRef Zhou X, Zhou P, Hu Z, et al. Diagnostic efficiency of quantitative contrast-enhanced ultrasound indicators for discriminating benign from malignant solid thyroid nodules. J Ultrasound Med. 2018;37:425–37.CrossRef
33.
Zurück zum Zitat Wang Y, Nie F, Liu T, et al. Revised value of contrast-enhanced ultrasound for solid hypo-echoic thyroid nodules graded with the thyroid imaging reporting and data system. Ultrasound Med Biol. 2018;44:930–40.CrossRef Wang Y, Nie F, Liu T, et al. Revised value of contrast-enhanced ultrasound for solid hypo-echoic thyroid nodules graded with the thyroid imaging reporting and data system. Ultrasound Med Biol. 2018;44:930–40.CrossRef
34.
Zurück zum Zitat Zhou Q, Jiang J, Shang X, et al. Correlation of contrast-enhanced ultrasonographic features with microvessel density in papillary thyroid carcinomas. Asian Pac J Cancer Prev. 2014;15:7449–522.CrossRef Zhou Q, Jiang J, Shang X, et al. Correlation of contrast-enhanced ultrasonographic features with microvessel density in papillary thyroid carcinomas. Asian Pac J Cancer Prev. 2014;15:7449–522.CrossRef
35.
Zurück zum Zitat Gao L, Xi X, Jiang Y, et al. Comparison among TIRADS (ACR TI-RADS and KWAK- TI-RADS) and 2015 ATA Guidelines in the diagnostic efficiency of thyroid nodules. Endocrine. 2019;64:90–6.CrossRef Gao L, Xi X, Jiang Y, et al. Comparison among TIRADS (ACR TI-RADS and KWAK- TI-RADS) and 2015 ATA Guidelines in the diagnostic efficiency of thyroid nodules. Endocrine. 2019;64:90–6.CrossRef
Metadaten
Titel
Incremental diagnostic value of shear wave elastography combined with contrast-enhanced ultrasound in TI-RADS category 4a and 4b nodules
verfasst von
Shao-Ting Huang
Bo Zhang
Hong-Ling Yin
Bo Li
Jin-Tang Liao
Yi-Bin Wang
Publikationsdatum
18.04.2020
Verlag
Springer Singapore
Erschienen in
Journal of Medical Ultrasonics / Ausgabe 3/2020
Print ISSN: 1346-4523
Elektronische ISSN: 1613-2254
DOI
https://doi.org/10.1007/s10396-020-01016-8

Weitere Artikel der Ausgabe 3/2020

Journal of Medical Ultrasonics 3/2020 Zur Ausgabe

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Klinik aktuell Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärztinnen und Psychotherapeuten.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.