Erschienen in:
19.04.2020 | Oncology
Independent external validation of nomogram to predict extracapsular extension in patients with prostate cancer
verfasst von:
Joao Ricardo Alves, Valdair F. Muglia, Fabiano R. Lucchesi, Raisa A. O. G. Faria, Cinthia Alcantara-Quispe, Vinicius L. Vazquez, Rodolfo B. Reis, Eliney F. Faria
Erschienen in:
European Radiology
|
Ausgabe 9/2020
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Abstract
Introduction
The objective of this study was to perform an independent external validation of the Giganti-Coppola nomogram (GCN), which uses clinical and radiological parameters to predict prostate extracapsular extension (ECE) on the final pathology of patients undergoing radical prostatectomy (RP).
Material and methods
Seventy-two patients diagnosed with prostate cancer (PCa), who were RP candidates from two institutions, were prospectively included. All patients underwent preoperative multi-parametric magnetic resonance imaging (mpMRI) at 1.5 T, without the use of an endorectal coil, with multiplanar images in T1WI, T2WI, DWI, and DCE. The AUC and a calibration graph were used to validate the nomogram, using the regression coefficients of the Giganti-Coppola study.
Results
The original nomogram had an AUC of 0.90 (p = 0.001), with a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 100%, 5.1%, 47.1%, 100%, and 48%, respectively. The calibration graph showed an overestimation of the nomogram for ECE.
Conclusion
The GCN has an adequate ability in predicting ECE; however, in our sample, it showed limited accuracy and overestimated likelihood of ECE in the final pathology of patients with PCa submitted to RP.
Key Points
• Knowledge of preoperative local staging of prostate cancer is essential for surgical treatment. Extracapsular extension increases the chance of positive surgical margins.
• Imaging modalities such as mpMRI alone does not have suitable accuracy in local staging.
• Giganti-Coppola’s nomogram achieved an adequate ability in predicting ECE.