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World Journal of Surgery
Erschienen in: World Journal of Surgery 10/2020

27.05.2020 | Original Scientific Report

Inflammatory Risk Factors for Early Recurrence of Non-Small Cell Lung Cancer Within One Year Following Curative Resection

verfasst von: Satoru Kobayashi, Yoko Karube, Yuji Matsumura, Morimichi Nishihira, Takashi Inoue, Osamu Araki, Sumiko Maeda, Masayuki Chida

Erschienen in: World Journal of Surgery | Ausgabe 10/2020

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Abstract

Background

Several inflammation-based scoring systems and nutritional indicators have been shown to have relevance to survival of patients with non-small cell lung cancer (NSCLC).The present study examined preoperative and pathological factors in patients who underwent curative resection for non-small cell lung cancer, with the aim to elucidate risk factors for early recurrence within 1 year of surgery.

Methods

Patients with NSCLC who underwent surgery from January 2009 to December 2014 were retrospectively investigated. Routine laboratory measurements including carcinoembryonic antigen were performed before surgery, and pathological information was collected after surgery. Patients with recurrence within 1 year after surgery were considered as early recurrence group (ERG), those with recurrence after 1 year were as late recurrence group (LRG), and those without recurrence were as no recurrence group (NRG).

Results

Multivariate analysis between ERG and LRG revealed Glasgow prognostic score (GPS) and CRP-to-albumin ratio (CAR) as independent risk factors for early recurrence. Multivariate analysis between ERG and LRG + NRG confirmed CAR, vascular invasion, and pathological stage as risk factors for early recurrence.

Conclusion

These findings indicated that CAR and GPS were confirmed to be risk factors for early recurrence, in addition to pathological factors.
Literatur
1.
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359–E386CrossRef
2.
Cancer Registry and Statistics. Cancer Information Service, National Cancer Center, Japan.
3.
Kuwano H, Amano J, Yokomise H (2012) Thoracic and cardiovascular surgery in Japan during 2010: annual report by The Japanese Association for Thoracic Surgery. Gen Thoracic surg 60:680–708CrossRef
4.
Chida M, Kobayashi S, Karube Y, Hayama M, Tamura M, Ishihama H et al (2012) Incidence of acute exacerbation of interstitial pneumonia in operated lung cancer: institutional report and review. Ann Thorac Cardiovasc Surg 18:314–317CrossRef
5.
Lopez Guerra JL, Gomez DR, Lin SH, Levy LB, Zhuang Y, Komaki R et al (2013) Risk factors for local and regional recurrence in patients with resected N0–N1 non-small-cell lung cancer, with implications for patient selection for adjuvant radiation therapy. Ann Oncol 24:67–74CrossRef
6.
Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860–867CrossRef
7.
Grange JM, Krone B, Mastrangelo G (2011) Infection, inflammation and cancer. Int J Cancer 128:2240–2241CrossRef
8.
Proctor MJ, Morrison DS, Talwar D, Balmar SM, Fletcher CD, O’Reilly DS et al (2011) A comparison of inflammation-based prognostic scores in patients with cancer A Glasgow Inflammation Outcome Study. Eur J Cancer. 47:2633–41CrossRef
9.
McMillan DC (2012) The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer. Cancer Treat Rev 39:534–540CrossRef
10.
Tomita M, Shimizu T, Ayabe T, Nakamura K, Onitsuka T (2012) Elevated preoperative inflammatory markers based on neutrophil-to-lymphocyte ratio and C-reactive protein predicts poor survival in resected non-small cell lung cancer. Anticancer Res 32:3535–3538PubMed
11.
Zhao QT, Yuan Z, Zhang H, Zhang XP, Wang HE, Wang ZK et al (2016) Prognostic role of platelet to lymphocyte ratio in non-small cell lung cancers: A meta-analysis including 3,720 patients. Int J Cancer 139:164–170CrossRef
12.
Warwick R, Mediratta N, Shackcloth M, Shaw M, McShane J, Poullis M (2014) Preoperative red cell distribution width in patients undergoing pulmonary resections for non-small-cell lung cancer. Eur J of Cardiothorac Surg 45:108–113CrossRef
13.
Yotsukura M, Ohtsuka T, Kaseda K, Kamiyama I, Hayashi Y, Asamura H (2016) Value of the glasgow prognostic score as a prognostic factor in resectable non-small cell lung cancer. J Thorac Oncol 11:1311–1318CrossRef
14.
Kawashima M, Murakawa T, Shinozaki T, Ichinose J, Hino H, Konoeda C et al (2015) Significance of the glasgow prognostic score as a prognostic indicator for lung cancer surgery. Interact Cardiovasc Thorac Surg 21:637–643CrossRef
15.
Pinato DJ, Shiner RJ, Seckl MJ, Stebbing J, Sharma R, Mauri FA (2014) Prognostic performance of inflammation-based prognostic indices in primary operable non-small cell lung cancer. Br J Cancer 110:1930–1935CrossRef
16.
Zhang F, Ying L, Jin J, Chen K, Zhang N, Wu J et al (2017) The C-reactive protein/albumin ratio predicts long-term outcomes of patients with operable non-small cell lung cancer. Oncotarget 8:8835–8842CrossRef
17.
18.
Kiankhooy A, Taylor MD, LaPar DJ, Isbell JM, Lau CL, Kozower BD et al (2014) Predictors of early recurrence for node-negative T1 to T2b non-small cell lung cancer. Ann Thorac Surg 98:1175–1183CrossRef
19.
Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357:539–545CrossRef
20.
Canna K, McArdle PA, McMillan DC, McNicol AM, Smith GW, McKee RF, McArdle CS (2005) The relationship between T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer. Br J Cancer 92:651–654CrossRef
21.
Moore MM, Chua W, Charles KA, Clarke SJ (2010) Inflammation and cancer: causes and consequences. Clin Pharmacol Ther 87:504–508CrossRef
22.
23.
Okada M, Nhisio W, Sakamoto T, Uchino K, Yuki T, Nakagawa A et al (2004) Prognostic significance of perioperative serum carcinoembryonic antigen in non-small cell lung cancer: analysis of 1,000 consecutive resections for clinical stage I disease. Ann Thorac Surg 78:216–221CrossRef
24.
Tomita M, Ayabe T, Chosa E, Nakamura K (2015) Postoperative serum CEA level is a more significant prognostic factor than post/preoperative serum CEA ratio in non-small cell cancer patients. Asian Pac Cancer Prev 16:7809–7812CrossRef
25.
Sakai T, Tsushima T, Kimura D, Hatanaka R, Yamada Y, Fukuda I (2011) A clinical study of the prognostic factors for postoperative early recurrence in patients who underwent complete resection for pulmonary adenocarcinoma. Ann Thorac Cardiovasc Surg 17:539–543CrossRef
26.
Forrest LM, McMillan DC, McArdle CS, Angerson WJ, Dunlop DJ (2003) Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer. Br J Cancer 89:1028–1030CrossRef
27.
Fairclough E, Cairns E, Hamilton J, Kelly C (2009) Evaluation of a modified early warning system for acute medical admissions and comparison with C-reactive protein/albumin ratio as a predictor of patient outcome. Clin Med (Lond) 9:30–33CrossRef
28.
Ranzani OT, Zampieri FG, Forte DN, Azevedo LC, Park M (2013) C-reactive protein/albumin ratio predicts 90-day mortality of septic patients. PLoS ONE 8:e59321CrossRef
29.
Kinoshita A, Onoda H, Imai N, Iwaku A, Oishi M, Tanaka K et al (2015) The C-reactive protein/albumin ratio, a novel inflammation-based prognostic score, predicts outcomes in patients with hepatocellular carcinoma. Ann Surg Oncol 22:803–810CrossRef
30.
Ishizuka M, Nagata H, Takagi K, Iwasaki Y, Shibuya N, Kubota K (2016) Clinical significance of the C-reactive protein to albumin ratio for survival after surgery for colorectal cancer. Ann Surg Oncol 23:900–907CrossRef
31.
Osugi J, Muto S, Matsumura Y, Higuchi M, Suzuki H, Gotoh M (2016) Prognostic impact of the high-sensitivity modified glasgow prognostic score in patients with resectable non-small cell lung cancer. J Cancer Res Ther 12:945–951CrossRef
32.
Koma Y, Onishi A, Matsuoka H, Oda N, Yokota N, Matsumoto Y et al (2013) Increased red cell distribution width associates with cancer stage and prognosis in patients with lung cancer. PLoS ONE 8:e80240CrossRef
33.
Kim EY, Kim N, Kim YS, Seo JY (2016) Prognostic significance of modified advanced lung cancer inflammation index (ALI) in patients with small cell lung cancer_comparison with original ALI. PLoS ONE 11:e0164056CrossRef
Metadaten
Titel
Inflammatory Risk Factors for Early Recurrence of Non-Small Cell Lung Cancer Within One Year Following Curative Resection
verfasst von
Satoru Kobayashi
Yoko Karube
Yuji Matsumura
Morimichi Nishihira
Takashi Inoue
Osamu Araki
Sumiko Maeda
Masayuki Chida
Publikationsdatum
27.05.2020
Verlag
Springer International Publishing
Erschienen in
World Journal of Surgery / Ausgabe 10/2020
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-020-05612-0

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