nach oben

Erschienen in:

26.06.2018

Inhalation of Simulated Smog Atmospheres Affects Cardiac Function in Mice

verfasst von: Haiyan Tong, Jonathan D. Krug, Q. Todd Krantz, Charly King, Marie M. Hargrove, M. Ian Gilmour, Stephen H. Gavett

Erschienen in: Cardiovascular Toxicology | Ausgabe 6/2018

Einloggen, um Zugang zu erhalten

Abstract

The health effects of individual criteria air pollutants have been well investigated. However, little is known about the health effects of air pollutant mixtures that more realistically represent environmental exposures. The present study was designed to evaluate the cardiac effects of inhaled simulated smog atmospheres (SA) generated from the photochemistry of either gasoline and isoprene (SA-G) or isoprene (SA-Is) in mice. Four-month-old female mice were exposed for 4 h to filtered air (FA), SA-G, or SA-Is. Immediately and 20 h after exposure, cardiac responses were assessed with a Langendorff preparation using a protocol consisting of 20 min of global ischemia followed by 2 h of reperfusion. Cardiac function was measured by index of left-ventricular developed pressure (LVDP) and cardiac contractility (dP/dt) before ischemia. Pre-ischemic LVDP was lower in mice immediately after SA-Is exposure (52.2 ± 5.7 cm H₂O compared to 83.9 ± 7.4 cm H₂O after FA exposure; p = 0.008) and 20 h after SA-G exposure (54.0 ± 12.7 cm H₂O compared to 79.3 ± 7.4 cm H₂O after FA exposure; p = 0.047). Pre-ischemic left ventricular contraction dP/dt_max was lower in mice immediately after SA-Is exposure (2025 ± 169 cm H₂O/sec compared to 3044 ± 219 cm H₂O/sec after FA exposure; p < 0.05) and 20 h after SA-G exposure (1864 ± 328 cm H₂O/sec compared to 2650 ± 258 cm H₂O/sec after FA exposure; p = 0.05). In addition, SA-G reduced the coronary artery flow rate 20 h after exposure compared to the FA control. This study demonstrates that acute SA-G and SA-Is exposures decrease LVDP and cardiac contractility in mice, indicating that photochemically-altered atmospheres affect the cardiovascular system.

Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., Peters, A., Siscovick, D., Smith, S. C. Jr., Whitsel, L., Kaufman, J. D., E. American Heart Association Council on, C.o.t.K.i.C. D. Prevention, P.A. Council on Nutrition, Metabolism. (2010). Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation, 121, 2331–2378.CrossRef

Kanakidou, M., Seinfeld, J. H., Pandis, S. N., Barnes, I., Dentener, F. J., Facchini, M. C., Van Dingenen, R., Ervens, B., Nenes, A., Nielsen, C. J., Swietlicki, E., Putaud, J. P., Balkanski, Y., Fuzzi, S., Horth, J., Moortgat, G. K., Winterhalter, R., Myhre, C. E. L., Tsigaridis, K., Vignati, E., Stephanou, E. G., Wilson, J.. (2005). Organic aerosol and global climate modelling: A review, Atmospheric Chemistry and Physics, 5, 1053–1123.CrossRef

Dominici, F., Peng, R. D., Barr, C. D., & Bell, M. L. (2010). Protecting human health from air pollution: Shifting from a single-pollutant to a multipollutant approach. Epidemiology, 21, 187–194.CrossRefPubMedPubMedCentral

Stieb, D. M., Burnett, R. T., Smith-Doiron, M., Brion, O., Shin, H. H., & Economou, V. (2008). A new multipollutant, no-threshold air quality health index based on short-term associations observed in daily time-series analyses. Journal of the Air & Waste Management Association, 58, 435–450.CrossRef

Hoffmann, B., Moebus, S., Mohlenkamp, S., Stang, A., Lehmann, N., Dragano, N., Schmermund, A., Memmesheimer, M., Mann, K., Erbel, R.,Jockel, K. H., & G. Heinz Nixdorf Recall Study Investigative. (2007). Residential exposure to traffic is associated with coronary atherosclerosis. Circulation, 116, 489–496.CrossRefPubMed

Adar, S. D., & Kaufman, J. D. Cardiovascular disease and air pollutants: Evaluating and improving epidemiological data implicating traffic exposure, Inhalation Toxicology, 19 Suppl 1 (2007) 135–149.CrossRefPubMed

Koren, H. S., Graham, D. E., & Devlin, R. B. (1992). Exposure of humans to a volatile organic mixture. III. Inflammatory response. Archives of Environmental Health, 47, 39–44.CrossRefPubMed

Pappas, G. P., Herbert, R. J., Henderson, W., Koenig, J., Stover, B., & Barnhart, S. (2000). The respiratory effects of volatile organic compounds. International Journal of Occupational and Environmental Health, 6, 1–8.CrossRefPubMed

Ye, D., Klein, M., Chang, H. H., Sarnat, J. A., Mulholland, J. A., Edgerton, E. S., Winquist, A., Tolbert, P. E., & Sarnat, S. E. (2017). Estimating acute cardiorespiratory effects of ambient volatile organic compounds. Epidemiology, 28, 197–206.CrossRefPubMedPubMedCentral

10.

Campen, M. J., Babu, N. S., Helms, G. A., Pett, S., Wernly, J., Mehran, R., & McDonald, J. D. (2005). Nonparticulate components of diesel exhaust promote constriction in coronary arteries from ApoE^−/− mice. Toxicological Sciences: An Official Journal of the Society of Toxicology, 88, 95–102.CrossRef

11.

Gentner, D. R., Jathar, S. H., Gordon, T. D., Bahreini, R., Day, D. A., El Haddad, I., Hayes, P. L., Pieber, S. M., Platt, S. M., de Gouw, J., Goldstein, A. H., Harley, R. A., Jimenez, J. L., Prevot, A. S., & Robinson, A. L. (2017). Review of urban secondary organic aerosol formation from gasoline and diesel motor vehicle emissions. Environmental Science & Technology, 51, 1074–1093.CrossRef

12.

Hallquist, M., Wenger, J. C., Baltensperger, U., Rudich, Y., Simpson, D., Claeys, M., Dommen, J., Donahue, N. M., George, C., Goldstein, A. H., Hamilton, J. F., Herrmann, H., Hoffmann, T., Iinuma, Y., Jang, M., Jenkin, M. E., Jimenez, J. L., Kiendler-Scharr, A., Maenhaut, W., McFiggans, G., Mentel, T. F., Monod, A., Prevot, A. S. H., Seinfeld, J. H., Surratt, J. D., Szmigielski, R., & Wildt, J. (2009). The formation, properties and impact of secondary organic aerosol: Current and emerging issues. Atmospheric Chemistry and Physics, 9, 5155–5236.CrossRef

13.

Carll, A. P., Crespo, S. M., Filho, M. S., Zati, D. H., Coull, B. A., Diaz, E. A., Raimundo, R. D., Jaeger, T. N. G., Ricci-Vitor, A. L., Papapostolou, V., Lawrence, J. E., Garner, D. M., Perry, B. S., Harkema, J. R., & Godleski, J. J. (2017). Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome. Particle and Fibre Toxicology, 14, 16.CrossRefPubMedPubMedCentral

14.

Guenther, A. B., Jiang, X., Heald, C. L., Sakulyanontvittaya, T., Duhl, T., Emmons, L. K., & Wang, X. (2012). The Model of Emissions of Gases and Aerosols from Nature version 2.1 (MEGAN2.1): An extended and updated framework for modeling biogenic emissions. Geoscientific Model Development, 5, 1471–1492.CrossRef

15.

Sharkey, T. D., & Monson, R. K. (2014). The future of isoprene emission from leaves, canopies and landscapes. Plant, Cell and Environment, 37, 1727–1740.CrossRefPubMed

16.

Williams, J., Roberts, J. M., Fehsenfeld, F. C., Bertman, S. B., Buhr, M. P., Goldan, P. D., Hubler, G., Kuster, W. C., Ryerson, T. B., Trainer, M., & Young, V. (1997). Regional ozone from biogenic hydrocarbons deduced from airborne measurements of PAN, PPN and MPAN. Geophysical Research Letters, 24, 1099–1102.CrossRef

17.

Claeys, M., Graham, B., Vas, G., Wang, W., Vermeylen, R., Pashynska, V., Cafmeyer, J., Guyon, P., Andreae, M. O., Artaxo, P., & Maenhaut, W. (2004). Formation of secondary organic aerosols through photooxidation of isoprene. Science, 303, 1173–1176.CrossRefPubMed

18.

Cho, S. H., Tong, H., McGee, J. K., Baldauf, R. W., Krantz, Q. T., & Gilmour, M. I. (2009). Comparative toxicity of size-fractionated airborne particulate matter collected at different distances from an urban highway. Environmental Health Perspectives, 117, 1682–1689.CrossRefPubMedPubMedCentral

19.

Tong, H., Cheng, W. Y., Samet, J. M., Gilmour, M. I., & Devlin, R. B. (2010). Differential cardiopulmonary effects of size-fractionated ambient particulate matter in mice. Cardiovascular Toxicology, 10, 259–267.CrossRefPubMed

20.

Cozzi, E., Hazarika, S., Stallings, H. W., Cascio, W. E., Devlin, R. B., Lust, R. M., Wingard, C. J., & Van Scott, M. R. (2006). Ultrafine particulate matter exposure augments ischemia-reperfusion injury in mice, American Journal of Physiology-Heart and Circulatory Physiology, 291, H894–H903.CrossRefPubMed

21.

McIntosh-Kastrinsky, R., Diaz-Sanchez, D., Sexton, K. G., Jania, C. M., Zavala, J., Tilley, S. L., Jaspers, I., Gilmour, M. I., Devlin, R. B., Cascio, W. E., & Tong, H. (2013). Photochemically altered air pollution mixtures and contractile parameters in isolated murine hearts before and after ischemia. Environmental Health Perspectives, 121, 1344–1348.CrossRefPubMedPubMedCentral

22.

Krug, J. D., Lewandowski, M., Offenberg, J. H., Turlington, J. M., Lonneman, W. A., Modak, N., Krantz, Q. T., King, C., Gavett, S. H., Gilmour, M. I., DeMarini, D. M., Kleindienst, T. E. (2018). Photochemical Conversion of surrogate emissions for use in toxicological studies: Role of particulate- and gas-phase products. Environmental Science & Technology, 52, 3037–3044.CrossRef

23.

Tong, H., McGee, J. K., Saxena, R. K., Kodavanti, U. P., Devlin, R. B., & Gilmour, M. I. (2009). Influence of acid functionalization on the cardiopulmonary toxicity of carbon nanotubes and carbon black particles in mice. Toxicology and Applied Pharmacology, 239, 224–232.CrossRefPubMed

24.

Campen, M., Robertson, S., Lund, A., Lucero, J., & McDonald, J. (2014). Engine exhaust particulate and gas phase contributions to vascular toxicity. Inhalation Toxicology, 26, 353–360.CrossRefPubMedPubMedCentral

25.

Carll, A. P., Hazari, M. S., Perez, C. M., Krantz, Q. T., King, C. J., Winsett, D. W., Costa, D. L., & Farraj, A. K. (2012). Whole and particle-free diesel exhausts differentially affect cardiac electrophysiology, blood pressure, and autonomic balance in heart failure-prone rats. Toxicological Sciences: An Official Journal of the Society of Toxicology, 128, 490–499.CrossRef

26.

Kurhanewicz, N., McIntosh-Kastrinsky, R., Tong, H., Walsh, L., Farraj, A. K., & Hazari, M. S. (2014). Ozone co-exposure modifies cardiac responses to fine and ultrafine ambient particulate matter in mice: Concordance of electrocardiogram and mechanical responses. Particle and Fibre Toxicology, 11, 54.CrossRefPubMedPubMedCentral

27.

Hazari, M. S., Haykal-Coates, N., Winsett, D. W., Costa, D. L., & Farraj, A. K. (2009). A single exposure to particulate or gaseous air pollution increases the risk of aconitine-induced cardiac arrhythmia in hypertensive rats. Toxicological sciences: An Official Journal of the Society of Toxicology, 112, 532–542.CrossRef

28.

Kurhanewicz, N., McIntosh-Kastrinsky, R., Tong, H., Ledbetter, A., Walsh, L., Farraj, A., & Hazari, M. (2017). TRPA1 mediates changes in heart rate variability and cardiac mechanical function in mice exposed to acrolein. Toxicology and Applied Pharmacology, 324, 51–60.CrossRefPubMed

29.

Mohamed, M. F., Kang, D., Aneja, V. P. (2002). Volatile organic compounds in some urban locations in United States. Chemosphere, 47, 863–882.CrossRef

30.

Takeshita, D., Nakajima-Takenaka, C., Shimizu, J., Hattori, H., Nakashima, T., Kikuta, A., Matsuyoshi, H., Takaki, M. (2009). Effects of formaldehyde on cardiovascular system in in situ rat hearts. Basic & Clinical Pharmacology & Toxicology, 105, 271–280.CrossRef

31.

Tani, T., Kogi, K., & Horiguchi, Y. (1986). Inhibitory effects of formaldehyde inhalation on the cardiovascular and respiratory systems in unanesthetized rabbits. Japanese Journal of Pharmacology, 40, 551–559.CrossRefPubMed

32.

Smith, L. E. (1965). Inhalation of the photochemical smog compound peroxyacetyl nitrate. American Journal of Public Health and the Nation’s Health, 55, 1460–1468.CrossRefPubMedPubMedCentral

33.

Niemann, B., Rohrbach, S., Miller, M. R., Newby, D. E., Fuster, V., & Kovacic, J. C. (2017). Oxidative stress and cardiovascular risk: Obesity, diabetes, smoking, and pollution: Part 3 of a 3-part series. Journal of the American College of Cardiology, 70, 230–251.CrossRefPubMedPubMedCentral

34.

Hazari, M. S., Haykal-Coates, N., Winsett, D. W., Krantz, Q. T., King, C., Costa, D. L., & Farraj, A. K. (2011). TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmias in hypertensive rats exposed to diesel exhaust. Environmental Health Perspectives, 119, 951–957.CrossRefPubMedPubMedCentral

35.

Oberdorster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Lunts, A., Kreyling, W., & Cox, C. (2002). Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. Journal of Toxicology and Environmental Health Part A, 65, 1531–1543.CrossRefPubMed

36.

LeBlanc, A. J., Moseley, A. M., Chen, B. T., Frazer, D., Castranova, V., & Nurkiewicz, T. R. (2010). Nanoparticle inhalation impairs coronary microvascular reactivity via a local reactive oxygen species-dependent mechanism. Cardiovascular Toxicology, 10, 27–36.CrossRefPubMedPubMedCentral

37.

Zhan, Y., Luo, Y., Deng, X., Grieneisen, M. L., Zhang, M., & Di, B. (2018). Spatiotemporal prediction of daily ambient ozone levels across China using random forest for human exposure assessment. Environmental Pollution, 233, 464–473.CrossRefPubMed

Titel: Inhalation of Simulated Smog Atmospheres Affects Cardiac Function in Mice
verfasst von: Haiyan Tong
Jonathan D. Krug
Q. Todd Krantz
Charly King
Marie M. Hargrove
M. Ian Gilmour
Stephen H. Gavett
Publikationsdatum: 26.06.2018
Verlag: Springer US
Erschienen in: Cardiovascular Toxicology / Ausgabe 6/2018
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI: https://doi.org/10.1007/s12012-018-9469-8

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2018

Effects of S-Nitrosoglutathione on Electrophysiological Manifestations of Mechanoelectric Feedback

Analysis of Safety Margin of Lithium Carbonate Against Cardiovascular Adverse Events Assessed in the Halothane-Anesthetized Dogs

Myocardial Injury from Tranylcypromine-Induced Hypertensive Crisis Secondary to Excessive Tyramine Intake

The Acute Effects of Age and Particulate Matter Exposure on Heart Rate and Heart Rate Variability in Mice

Application of a Simple Quantitative Assessment of Atherosclerotic Lesions in Freshly Isolated Aortas from Rabbits

The Effects of Lipid Emulsion, Magnesium Sulphate and Metoprolol in Amitriptyline-Induced Cardiovascular Toxicity in Rats