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Cardiovascular Toxicology
Erschienen in: Cardiovascular Toxicology 6/2018

17.05.2018

The Acute Effects of Age and Particulate Matter Exposure on Heart Rate and Heart Rate Variability in Mice

verfasst von: Blake A. Bennett, Ernst W. Spannhake, Ana M. Rule, Patrick N. Breysse, Clarke G. Tankersley

Erschienen in: Cardiovascular Toxicology | Ausgabe 6/2018

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Abstract

Exposure to ambient particulate matter (PM) is associated with increased cardiac morbidity and mortality with the elderly considered to be the most susceptible. The purpose of this study was to determine if exposure to PM would cause a greater impact on heart regulation in older DBA/2 (D2) male mice as determined by changes in heart rate (HR) and heart rate variability (HRV). D2 mice at the ages of 4, 12, and 19 months were instilled with 100 µg of PM or saline by aspiration. Before and after the aspiration, 3-min echocardiogram (ECG) samples for HR and HRV were recorded at 15-min intervals for 3 h along with corresponding measurements of homeostasis, such as temperature, metabolism, and ventilation. PM exposure resulted in an increase in HRV, declines in HR, and altered measures of homeostasis for a subset of the 12-mo mice. The PM aspiration did not affect cardiac or homeostasis parameters in the 4- or 19-mo mice. Our results suggest that a select group of middle-age mice are more susceptible to alterations in their heart rhythm after PM exposure and highlight that there are acute age-related differences in heart rhythm following PM exposure.
Literatur
1.
Peng, R. D., Chang, H. H., Bell, M. L., McDermott, A., Zeger, S. L., Samet, J. M., & Dominici, F. (2008). Coarse particulate matter air pollution and hospital admissions for cardiovascular and respiratory diseases among Medicare patients. JAMA, 299, 2172–2179.CrossRefPubMedPubMedCentral
2.
Zanobetti, A., & Schwartz, J. (2009). The effect of fine and coarse particulate air pollution on mortality: A national analysis. Environmental Health Perspectives, 117, 898–903.CrossRefPubMedPubMedCentral
3.
Dominici, F., Peng, R. D., Bell, M. L., Pham, L., McDermott, A., Zeger, S. L., & Samet, J. M. (2006). Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA, 295, 1127–1134.CrossRefPubMedPubMedCentral
4.
Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., Peters, A., Siscovick, D., Smith, S. C., Whitsel, L., & Kaufman, J. D. (2010). Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation, 121, 2331–2378.CrossRefPubMed
5.
Task Force. (1996). Heart rate variability: Standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation, 93, 1043–1065.CrossRef
6.
Bilchick, K. C., Fetics, B., Djoukeng, R., Fisher, S. G., Fletcher, R. D., Singh, S. N., Nevo, E., & Berger, R. D. (2002). Prognostic value of heart rate variability in chronic congestive heart failure (Veterans Affairs’ Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure). American Journal of Cardiology, 90, 24–28.CrossRefPubMed
7.
Tsuji, H., Venditti, F. J., Manders, E. S., Evans, J. C., Larson, M. G., Feldman, C. L., & Levy, D. (1994). Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation, 90, 878–883.CrossRefPubMed
8.
Zeka, A., Zanobetti, A., & Schwartz, J. (2006). Individual-level modifiers of the effects of particulate matter on daily mortality. American Journal of Epidemiology, 163, 849–859.CrossRefPubMed
9.
Adar, S. D., Gold, D. R., Coull, B. A., Schwartz, J., Stone, P. H., & Suh, H. (2007). Focused exposures to airborne traffic particles and heart rate variability in the elderly. Epidemiology, 18, 95–103.CrossRefPubMed
10.
Pope, C. A., Hansen, M. L., Long, R. W., Nielsen, K. R., Eatough, N. L., Wilson, W. E., & Eatough, D. J. (2004). Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects. Environmental Health Perspectives, 112, 339–345.CrossRefPubMedPubMedCentral
11.
Sullivan, J. H., Schreuder, A. B., Trenga, C. A., Liu, S. L., Larson, T. V., Koenig, J. Q., & Kaufman, J. D. (2005). Association between short term exposure to fine particulate matter and heart rate variability in older subjects with and without heart disease. Thorax, 60, 462–466.CrossRefPubMedPubMedCentral
12.
Hamade, A. K., & Tankersley, C. G. (2009). Interstrain variation in cardiac and respiratory adaptation to repeated ozone and particulate matter exposures. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 296, R1202–R1215.CrossRefPubMedPubMedCentral
13.
Ramos-Bonilla, J. P., Breysse, P. N., Dominici, F., Geyh, A., & Tankersley, C. G. (2010). Ambient air pollution alters heart rate regulation in aged mice. Inhalation Toxicology, 22, 330–339.CrossRefPubMed
14.
Tankersley, C. G., Campen, M., Bierman, A., Flanders, S. E., Broman, K. W., & Rabold, R. (2004). Particle effects on heart-rate regulation in senescent mice. Inhalation Toxicology, 16, 381–390.CrossRefPubMed
15.
Calvi, C. L., Podowski, M., D’Alessio, F. R., Metzger, S. L., Misono, K., Poonyagariyagorn, H., Lopez-Mercado, A., Ku, T., Lauer, T., Cheadle, C., Talbot, C. C., Jie, C., McGrath-Morrow, S., King, L. S., Walston, J., & Neptune, E. R. (2011). Critical transition in tissue homeostasis accompanies murine lung senescence. PLoS ONE, 6, e20712.CrossRefPubMedPubMedCentral
16.
Flurkey, K., Currer, J. M., & Harrison, D. E. (2007). Mouse Models in Aging Research. In J. G. Fox, M. T. Davisson, F. W. Quimby, S. W. Barthold, C. E. Newcomer & A. L. Smith (Eds.), The mouse in biomedical (pp. 637–672). Burlington, MA: Research American College of Laboratory Animal Medicine.CrossRef
17.
Tankersley, C. G., Irizarry, R., Flanders, S. E., Rabold, R., & Frank, R. (2003). Unstable heart rate and temperature regulation predict mortality in AKR/J mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 284, R742-750.CrossRef
18.
Rule, A. M., Geyh, A. S., Ramos-Bonilla, J. P., Mihalic, J. N., Margulies, J. D., Polyak, L. M., Kesavan, J., & Breysse, P. N. (2010). Design and characterization of a sequential cyclone system for the collection of bulk particulate matter. Journal of Environmental Monitoring, 12, 1807–1814.CrossRefPubMed
19.
Han, I., Mihalic, J. N., Ramos-Bonilla, J. P., Rule, A. M., Polyak, L. M., Peng, R. D., Geyh, A. S., & Breysse, P. N. (2012). Assessment of heterogeneity of metal composition of fine particulate matter collected from eight US counties using principal component analysis. Journal of the Air & Waste Management Association, 62, 773–782.CrossRef
20.
Sokal, R. S., Rohlf, F. J. (1995). Biometry. New York: W. H. Freeman and Company.
21.
Ramsay, J. O., & Silverman, B. W. (2005). Functional data analysis. New York: Springer.CrossRef
22.
Campen, M. J., Nolan, J. P., Schladweiler, M. C., Kodavanti, U. P., Costa, D. L., & Watkinson, W. P. (2002). Cardiac and thermoregulatory effects of instilled particulate matter-associated transition metals in healthy and cardiopulmonary-compromised rats. Journal of Toxicology and Environmental Health, Part A, 65, 1615–1631.CrossRef
23.
Farraj, A. K., Hazari, M. S., Haykal-Coates, N., Lamb, C., Winsett, D. W., Ge, Y., Ledbetter, A. D., Carll, A. P., Bruno, M., Ghio, A., & Costa, D. L. (2011). ST depression, arrhythmia, vagal dominance, and reduced cardiac micro-RNA in particulate-exposed rats. American Journal of Respiratory Cell and Molecular Biology, 44, 185–196.CrossRefPubMed
24.
Coleridge, H. M., & Coleridge, J. C. (1994). Pulmonary reflexes: Neural mechanisms of pulmonary defense. Annual Review of Physiology, 56, 69–91.CrossRefPubMed
25.
Widdicombe, J., & Lee, L. Y. (2001). Airway reflexes, autonomic function, and cardiovascular responses. Environmental Health Perspectives, 109(Suppl 4), 579–584.CrossRefPubMedPubMedCentral
26.
Perez, C. M., Hazari, M. S., & Farraj, A. K. (2015). Role of autonomic reflex arcs in cardiovascular responses to air pollution exposure. Cardiovascular Toxicology, 15(1), 69–78.CrossRefPubMedPubMedCentral
27.
Campen, M. J., Nolan, J. P., Schladweiler, M. C., Kodavanti, U. P., Evansky, P. A., Costa, D. L., & Watkinson, W. P. (2001). Cardiovascular and thermoregulatory effects of inhaled PM-associated transition metals: A potential interaction between nickel and vanadium sulfate. Toxicological Sciences, 64, 243–252.CrossRefPubMed
28.
Watkinson, W. P., Campen, M. J., Lyon, J. Y., Highfill, J. W., Wiester, M. J., & Costa, D. L. (1997). Impact of the hypothermic response in inhalation toxicology studies. Annals of the New York Academy of Sciences, 813, 849–863.CrossRefPubMed
29.
Gordon, C. J., Spencer, P. J., Hotchkiss, J., Miller, D. B., Hinderliter, P. M., & Pauluhn, J. (2008). Thermoregulation and its influence on toxicity assessment. Toxicology, 244, 87–97.CrossRefPubMed
30.
Sacks, J. D., Stanek, L. W., Luben, T. J., Johns, D. O., Buckley, B. J., Brown, J. S., & Ross, M. (2011). Particulate matter-induced health effects: Who is susceptible? Environmental Health Perspectives, 119, 446–454.CrossRefPubMed
31.
Bandinelli, S., Corsi, A. M., Milaneschi, Y., & Vazzana, R. (2010). Frailty and the homeostatic network. Acta Bio Medica Atenei Parmensis, 81(Suppl 1), 15–18.PubMed
32.
Kyriazis, M. (2003). Practical applications of chaos theory to the modulation of human ageing: Nature prefers chaos to regularity. Biogerontology, 4, 75–90.CrossRefPubMed
33.
Rey-Robert, B., Temprado, J. J., & Berton, E. (2011). Aging and changes in complexity in the neurobehavioral system. Medicina (Kaunas), 47, 1–10.CrossRef
34.
Lipsitz, L. A. (2004). Physiological complexity, aging, and the path to frailty. Science of Aging Knowledge Environment, 2004, pe16.CrossRefPubMed
35.
Pikkujamsa, S. M., Makikallio, T. H., Sourander, L. B., Raiha, I. J., Puukka, P., Skytta, J., Peng, C. K., Goldberger, A. L., & Huikuri, H. V. (1999). Cardiac interbeat interval dynamics from childhood to senescence: Comparison of conventional and new measures based on fractals and chaos theory. Circulation, 100, 393–399.CrossRefPubMed
36.
Xiao, R. P., Tomhave, E. D., Wang, D. J., Ji, X., Boluyt, M. O., Cheng, H., Lakatta, E. G., & Koch, W. J. (1998). Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases. Journal of Clinical Investigation, 101, 1273–1282.CrossRefPubMedPubMedCentral
37.
Wang, T., Lang, G. D., Moreno-Vinasco, L., Huang, Y., Goonewardena, S. N., Peng, Y. J., Svensson, E. C., Natarajan, V., Lang, R. M., Linares, J. D., Breysse, P. N., Geyh, A. S., Samet, J. M., Lussier, Y. A., Dudley, S., Prabhakar, N. R., & Garcia, J. G. (2012). Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels. American Journal of Respiratory Cell and Molecular Biology, 46(4), 524–531.CrossRefPubMedPubMedCentral
38.
Wagner, J. G., Allen, K., Yang, H., Nan, B., Morishita, M., Mukherjee, B., Dvonch, J. T., Spino, C., Fink, G. D., Rajagopalan, S., Sun, Q., Brook, R. D., & Harkema, J. R. (2014). Cardiovascular depression in rats exposed to inhaled particulate matter and ozone: Effects of diet-induced metabolic syndrome. Environmental Health Perspectives, 122(1), 27–33.CrossRefPubMed
39.
Hazari, M. S., Haykal-Coates, N., Winsett, D. W., Costa, D. L., & Farraj, A. K. (2009). A single exposure to particulate or gaseous air pollution increases the risk of aconitine-induced cardiac arrhythmia in hypertensive rats. Toxicological Sciences, 112, 532–542.CrossRefPubMed
40.
Anselme, F., Loriot, S., Henry, J. P., Dionnet, F., Napoleoni, J. G., Thuillez, C., & Morin, J. P. (2007). Inhalation of diluted diesel engine emission impacts heart rate variability and arrhythmia occurrence in a rat model of chronic ischemic heart failure. Archives of Toxicology, 81(4), 299–307.CrossRefPubMed
41.
Farraj, A. K., Haykal-Coates, N., Winsett, D. W., Gilmour, M. I., King, C., Krantz, Q. T., Richards, J., & Hazari, M. S. (2015). Comparative electrocardiographic, autonomic and systemic inflammatory responses to soy biodiesel and petroleum diesel emissions in rats. Inhalation Toxicology, 27(11), 564–575.CrossRefPubMed
42.
Carll, A. P., Crespo, S. M., Filho, M. S., Zati, D. H., Coull, B. A., Diaz, E. A., Raimundo, R. D., Jaeger, T. N. G., Ricci-Vitor, A. L., Papapostolou, V., Lawrence, J. E., Garner, D. M., Perry, B. S., Harkema, J. R., & Godleski, J. J. (2017). Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome. Particle and Fibre Toxicology, 14, 16.CrossRefPubMedPubMedCentral
Metadaten
Titel
The Acute Effects of Age and Particulate Matter Exposure on Heart Rate and Heart Rate Variability in Mice
verfasst von
Blake A. Bennett
Ernst W. Spannhake
Ana M. Rule
Patrick N. Breysse
Clarke G. Tankersley
Publikationsdatum
17.05.2018
Verlag
Springer US
Erschienen in
Cardiovascular Toxicology / Ausgabe 6/2018
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI
https://doi.org/10.1007/s12012-018-9461-3

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