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Inflammation
Erschienen in: Inflammation 1/2016

01.02.2016

Inhibition of Radiation-Induced Oxidative Damage in the Lung Tissue: May Acetylsalicylic Acid Have a Positive Role?

verfasst von: Can Demirel, Sevil Cagiran Kilciksiz, Serkan Gurgul, Nurten Erdal, Seyran Yigit, Lulufer Tamer, Lokman Ayaz

Erschienen in: Inflammation | Ausgabe 1/2016

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Abstract

The lung is relatively sensitive to irradiation. It is shown that acetylsalicylic acid (ASA) might reduce oxidative injury and that it has a place in protection from cancer. The aim of this study is to evaluate the potential radioprotective effects of ASA. Whole-body irradiation (6 Gy, single dose) was applied to the rats. Glutathione (GSH), malondialdehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) levels in the lung tissue were measured. Control (C), Radiation (R), Radiation + ASA (R + ASA; received irradiation and 25 mg/kg of ASA intraperitoneally (i.p.)), and Radiation + Amifostine (R + WR-2721; received irradiation and 200 mg/kg of WR-2721 i.p.) groups were used. The MPO levels decreased statistically significantly in the group administered ASA. Histopathologically, a radioprotective effect of ASA was more evident in the R + ASA group. ASA is an agent which has not been used as a radioprotector in the clinic yet, and it is worth supporting with more advanced studies.
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Metadaten
Titel
Inhibition of Radiation-Induced Oxidative Damage in the Lung Tissue: May Acetylsalicylic Acid Have a Positive Role?
verfasst von
Can Demirel
Sevil Cagiran Kilciksiz
Serkan Gurgul
Nurten Erdal
Seyran Yigit
Lulufer Tamer
Lokman Ayaz
Publikationsdatum
01.02.2016
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 1/2016
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-015-0234-x

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