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Journal of Natural Medicines

Erschienen in:

01.07.2010 | Natural Resource Letter

Inhibitory effect of the flowers of artichoke (Cynara cardunculus) on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin

verfasst von: Ken Yasukawa, Hideki Matsubara, Yuri Sano

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2010

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Abstract

The methanol extract of the flowers of artichoke (Cynara cardunculus) exhibited remarkable antitumor activity in an in vivo two-stage carcinogenesis test in mice, using 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. From the active fraction of the methanol extract, four triterpene alcohols and their corresponding acetates were isolated and identified. These compounds were evaluated for their inhibitory effects on TPA-induced inflammation (1 μg/ear) in mice and showed marked anti-inflammatory effects, with a 50% inhibitory dose of 0.50–0.91 μmol/ear.

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Titel: Inhibitory effect of the flowers of artichoke (Cynara cardunculus) on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin
verfasst von: Ken Yasukawa
Hideki Matsubara
Yuri Sano
Publikationsdatum: 01.07.2010
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 3/2010
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-010-0403-z

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Inhibitory effect of the flowers of artichoke (Cynara cardunculus) on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin

Abstract

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

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