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Current Neurology and Neuroscience Reports

Erschienen in:

01.08.2017 | Sleep (M Thorpy and M Billiard, Section Editors)

Insomnia Disorder and Brain’s Default-Mode Network

verfasst von: Daniel Ruivo Marques, Ana Allen Gomes, Gina Caetano, Miguel Castelo-Branco

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 8/2018

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Abstract

Purpose of Review

Insomnia disorder (ID) is a prevalent sleep disorder that significantly compromises the physical and mental health of individuals. This article reviews novel approaches in the study of brain networks and impaired function in ID through the application of modern neuroimaging techniques such as functional magnetic resonance imaging (fMRI).

Recent Findings

The default-mode network (DMN) is presumed to be correlated with self-referential information processing, and it appears to be altered or unbalanced in insomnia.

Summary

A growing body of evidence suggests the lack of deactivation of brain regions comprising the DMN when insomnia patients are at rest. Moreover, core areas of the DMN demonstrate greater activation in insomnia patients when compared to healthy controls in self-referential related tasks. Despite the few studies on the topic, underpinning the correlation between abnormal DMN activity and ID deserves further attention in the future. Implications for therapeutics are briefly outlined.

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• Marques D, Clemente V, Gomes A, Azevedo MH. Profiling insomnia using subjective measures: where are we and where are we going. Sleep Med. 2018; https://doi.org/10.1016/j.sleep.2017.12.006. The authors highlight the importance of profiling insomnia disorder.

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•• Marques D, Gomes A, Clemente V, Santos J, Castelo-Branco M. Default-mode network activity and its role in comprehension and management of psychophysiological insomnia: a new perspective. New Ideas Psychol. 2015;36:30–7. https://doi.org/10.1016/j.newideapsych.2014.08.001. This is the first structured reflection on the role of DMN for insomnia. Several benefits and caveats are identified. CrossRef

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•• Regen W, Kyle S, Nissen C, Feige B, Baglioni C, Hennig J, et al. Objective sleep disturbances are associated with greater waking resting-state connectivity between the retrosplenial cortex/hippocampus and various nodes of the default mode network. J Psychiatry Neurosci. 2016;41:295–303. https://doi.org/10.1503/jpn.140290. A recent study showing connectivity impairment in DMN in insomnia. CrossRefPubMedPubMedCentral

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•• Marques D, Gomes A, Clemente V, Santos J, Duarte I, Caetano G, et al. Self-referential dysfunction and default mode hyperactivation in insomnia patients: a case-control fMRI study. J Psychophysiol. 2017:1–16. https://doi.org/10.1027/0269-8803/a000194. This study reports, among other things, the absence of DMN deactivation when insomnia patients are performing a passive task.

23.

•• Marques D, Gomes A, Clemente V, Santos J, Duarte I, Caetano G, et al. Unbalanced resting-state networks activity in psychophysiological insomnia. Sleep Biol Rhythms. 2017;15:167–77. https://doi.org/10.1007/s41105-017-0096-8. A small albeit relevant case-control fMRI study using functional connectivity technique, which showed various impairments in resting-state networks in insomnia. CrossRef

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•• Li C, Dong M, Yin Y, Hua K, Fu S, Jiang G. Abnormal whole-brain functional connectivity in patients with primary insomnia. Neuropsychiatr Dis Treat. 2017;13:427–35. https://doi.org/10.2147/NDT.S128811. A recent study showing connectivity impairment in DMN in insomnia. CrossRefPubMedPubMedCentral

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•• Dong X, Qin H, Wu T, Hu T, Liao K, Cheng F, et al. Rest but busy: aberrant resting-state functional connectivity of triple network model in insomnia. Brain Behav. 2018;8:e00876. https://doi.org/10.1002/brb3.876. A recent study showing connectivity impairment in DMN in insomnia. CrossRefPubMedPubMedCentral

26.

•• Marques D, Gomes A, Clemente V, Santos J, Duarte I, Caetano G, Castelo-Branco M. The effect of tailored cognitive-behavioral therapy on neurobiological function in insomnia patients: an fMRI study. 2017: Manuscript submitted for publication. This is a relevant study which investigated the effects of CBT-I on neurobiological function, in particular, on DMN and self-referential cognitive processing.

27.

•• Lee Y-J, Kim S, Kim N, Choi J-W, Park J, Kim S, et al. Changes in subcortical resting-state functional connectivity in patients with psychophysiological insomnia after cognitive–behavioral therapy. Neuroimage Clin. 2018;17:115–23. https://doi.org/10.1016/j.nicl.2017.10.013. This is a recent study which outlines that functional connectivity of insomnia patients differs from good sleepers and changes after CBT-I. CrossRefPubMed

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Linden D. How psychotherapy changes the brain: the contribution of functional neuroimaging. Mol Psychiatry. 2006;11:528–38. https://doi.org/10.1038/sj.mp.4001816.CrossRefPubMed

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• Marques D, Gomes A, Clemente V, Santos J, Caetano G, Castelo-Branco M. Neurobiological correlates of psychological treatments for insomnia: a review. Eur Psychol. 2016;21:195–205. https://doi.org/10.1027/1016-9040/a000264. A review about the neural correlates of psychotherapeutic interventions for insomnia. CrossRef

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Marques D. Do we need neuroimaging to treat insomnia effectively? Sleep Med. 2017; https://doi.org/10.1016/j.sleep.2017.08.005.

Titel: Insomnia Disorder and Brain’s Default-Mode Network
verfasst von: Daniel Ruivo Marques
Ana Allen Gomes
Gina Caetano
Miguel Castelo-Branco
Publikationsdatum: 01.08.2017
Verlag: Springer US
Erschienen in: Current Neurology and Neuroscience Reports / Ausgabe 8/2018
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-018-0861-3

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Abstract

Purpose of Review

Recent Findings

Summary

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