Erschienen in:
01.07.2008 | Letter
Insulin may have a role to play in protecting beta cells from deterioration in diabetes
verfasst von:
A. Del Parigi
Erschienen in:
Diabetologia
|
Ausgabe 7/2008
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Excerpt
To the Editor: In a recent paper, Aston-Mourney and colleagues discuss evidence suggesting that insulin hypersecretion could be a primary causal defect of type 2 diabetes mellitus and that increasing beta cell secretion might actually accelerate the progression to beta cell failure [
1]. As a consequence, the authors point out that insulin secretagogues such as sulfonylureas, still widely used in the treatment of diabetes, can be detrimental. Conversely, experimental treatments that put the beta cell at rest, such as diazoxide, are reported as protective of beta cells. …