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Reviews in Endocrine and Metabolic Disorders
Erschienen in: Reviews in Endocrine and Metabolic Disorders 2/2021

14.10.2020 | Insulins

Molecular prospect of type-2 diabetes: Nanotechnology based diagnostics and therapeutic intervention

verfasst von: Rout George Kerry, Gyana Prakash Mahapatra, Ganesh Kumar Maurya, Sushmita Patra, Subhasis Mahari, Gitishree Das, Jayanta Kumar Patra, Sabuj Sahoo

Erschienen in: Reviews in Endocrine and Metabolic Disorders | Ausgabe 2/2021

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Abstract

About ninety percent of all diabetic conditions account for T2D caused due to abnormal insulin secretion/ action or increased hepatic glucose production. Factors that contribute towards the aetiology of T2D could be well explained through biochemical, molecular, and cellular aspects. In this review, we attempt to explain the recent evolving molecular and cellular advancement associated with T2D pathophysiology. Current progress fabricated in T2D research concerning intracellular signaling cascade, inflammasome, autophagy, genetic and epigenetics changes is discretely explained in simple terms. Present available anti-diabetic therapeutic strategies commercialized and their limitations which are needed to be acknowledged are addressed in the current review. In particular, the pre-eminence of nanotechnology-based approaches to nullify the inadequacy of conventional anti-diabetic therapeutics and heterogeneous nanoparticulated systems exploited in diabetic researches are also discretely mentioned and are also listed in a tabular format in the review. Additionally, as a future prospect of nanotechnology, the review presents several strategic hypotheses to ameliorate the austerity of T2D by an engineered smart targeted nano-delivery system. In detail, an effort has been made to hypothesize novel nanotechnological based therapeutic strategies, which exploits previously described inflammasome, autophagic target points. Utilizing graphical description it is explained how a smart targeted nano-delivery system could promote β-cell growth and development by inducing the Wnt signaling pathway (inhibiting Gsk3β), inhibiting inflammasome (inhibiting NLRP3), and activating autophagic target points (protecting Atg3/Atg7 complex from oxidative stress) thereby might ameliorate the severity of T2D. Additionally, several targeting molecules associated with autophagic and epigenetic factors are also highlighted, which can be exploited in future diabetic research.
Literatur
1.
2.
Morris AP. Progress in defining the genetic contribution to type 2 diabetes susceptibility. Curr Opin Genet Dev. 2018;50:41–51.PubMed
3.
Matboli M, Shafei A, Ali M, Kamal KM, Noah M, Lewis P, et al. Emerging role of nutrition and the non-coding landscape in type 2 diabetes mellitus: a review of literature. Gene. 2018;675:54–61.PubMed
4.
Chaudhury A, Duvoor C, Reddy Dendi VS, Kraleti S, Chada A, Ravilla R, et al. Clinical review of antidiabetic drugs: implications for type 2 diabetes mellitus management. Front Endocrinol. 2017;8:6.
5.
Blaslov K, Naranđa FS, Kruljac I, Renar IP. Treatment approach to type 2 diabetes: past, present and future. World J Diabetes. 2018;9:209–19.PubMedPubMedCentral
6.
Kumar A, Bharti SK, Kumar A. Therapeutic molecules against type 2 diabetes: what we have and what are we expecting? Pharmacol Rep. 2017;69:959–70.PubMed
7.
Yang J-S, Lu C-C, Kuo S-C, Hsu Y-M, Tsai S-C, Chen S-Y, et al. Autophagy and its link to type II diabetes mellitus. Biomedicine. 2017;7:8.PubMedPubMedCentral
8.
Keçili R, Büyüktiryaki S, Hussain CM. Advancement in bioanalytical science through nanotechnology: past, present and future. TrAC Trends Analyt Chem. 2019;110:259–76.
9.
Oslowski CM, Hara T, O’Sullivan-Murphy B, Kanekura K, Lu S, Hara M, et al. Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab. 2012;16:265–73.PubMedPubMedCentral
10.
Rai RC, Bagul PK, Banerjee SK. NLRP3 inflammasome drives inflammation in high fructose fed diabetic rat liver: effect of resveratrol and metformin. Life Sci. 2020;253:117727.PubMed
11.
12.
Bhansali S, Bhansali A, Walia R, Saikia UN, Dhawan V. Alterations in mitochondrial oxidative stress and mitophagy in subjects with prediabetes and type 2 diabetes mellitus. Front Endocrinol (Lausanne). 2017;8:347.
13.
Sikhayeva N, Iskakova A, Saigi-Morgui N, Zholdybaeva E, Eap C-B, Ramanculov E. Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study. BMC Med Genet. 2017;18:76.PubMedPubMedCentral
14.
Rosen ED, Kaestner KH, Natarajan R, Patti M-E, Sallari R, Sander M, et al. Epigenetics and epigenomics: implications for diabetes and obesity. Diabetes. 2018;67:1923–31.PubMedPubMedCentral
15.
16.
Goldfine AB, Shoelson SE. Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk. J Clin Invest. American Society for Clinical Investigation; 2017;127:83–93.
17.
Cao Q, Chen X-M, Huang C, Pollock CA. MicroRNA as novel biomarkers and therapeutic targets in diabetic kidney disease: an update. FASEB Bioadv. 2019;1:375–88.PubMedPubMedCentral
18.
19.
20.
Evans ER, Bugga P, Asthana V, Drezek R. Metallic nanoparticles for cancer immunotherapy. Mater Today (Kidlington). 2018;21:673–85.PubMed
21.
Li H, Wu X, Yang B, Li J, Xu L, Liu H, et al. Evaluation of biomimetically synthesized mesoporous silica nanoparticles as drug carriers: structure, wettability, degradation, biocompatibility and brain distribution. Mater Sci Eng C Mater Biol Appl. 2019;94:453–64.PubMed
22.
Sepehri Z, Kiani Z, Afshari M, Kohan F, Dalvand A, Ghavami S. Inflammasomes and type 2 diabetes: an updated systematic review. Immunol Lett. 2017;192:97–103.PubMed
23.
Han CY, Rho HS, Kim A, Kim TH, Jang K, Jun DW, et al. FXR inhibits endoplasmic reticulum stress-induced NLRP3 inflammasome in hepatocytes and ameliorates liver injury. Cell Rep. 2018;24:2985–99.PubMed
24.
Solini A, Novak I. Role of the P2X7 receptor in the pathogenesis of type 2 diabetes and its microvascular complications. Curr Opin Pharmacol. 2019;47:75–81.PubMed
25.
Bhattacharya D, Mukhopadhyay M, Bhattacharyya M, Karmakar P. Is autophagy associated with diabetes mellitus and its complications? A review. EXCLI J. 2018;17:709–20.PubMedPubMedCentral
26.
Li S, Du L, Zhang L, Hu Y, Xia W, Wu J, et al. Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line. J Biol Chem. 2013;288:30094–104.PubMedPubMedCentral
27.
Xu W-Q, Wang Y-S. The role of Toll-like receptors in retinal ischemic diseases. Int J Ophthalmol. 2016;9:1343–51.PubMedPubMedCentral
28.
Griffin C, Eter L, Lanzetta N, Abrishami S, Varghese M, McKernan K, et al. TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c+ adipose tissue macrophage production in obese mice. J Biol Chem. 2018;293:8775–86.PubMedPubMedCentral
29.
Rulifson IC, Karnik SK, Heiser PW, ten Berge D, Chen H, Gu X, et al. Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci USA. 2007;104:6247–52.PubMed
30.
Duvillié B. Vascularization of the pancreas: an evolving role from embryogenesis to adulthood. Diabetes. 2013;62:4004–5.PubMedPubMedCentral
31.
Halim M, Halim A. The effects of inflammation, aging and oxidative stress on the pathogenesis of diabetes mellitus (type 2 diabetes). Diabetes Metab Syndr: Clin Res Rev. 2019;13:1165–72.
32.
Chen Z. Adapter proteins regulate insulin resistance and lipid metabolism in obesity. Sci Bull. 2016;61:1489–97.
33.
Sah SP, Singh B, Choudhary S, Kumar A. Animal models of insulin resistance: A review. Pharmacol Rep. 2016;68:1165–77.PubMed
34.
Vethe H, Ghila L, Berle M, Hoareau L, Haaland ØA, Scholz H, et al. The effect of Wnt pathway modulators on human iPSC-derived pancreatic beta cell maturation. Front Endocrinol (Lausanne). 2019;10:293.
35.
Scheibner K, Bakhti M, Bastidas-Ponce A, Lickert H. Wnt signaling: implications in endoderm development and pancreas organogenesis. Curr Opin Cell Biol. 2019;61:48–55.PubMed
36.
Bastidas-Ponce A, Roscioni SS, Burtscher I, Bader E, Sterr M, Bakhti M, et al. Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells. Mol Metab. 2017;6:524–34.PubMedPubMedCentral
37.
Fujimoto K, Polonsky KS. Pdx1 and other factors that regulate pancreatic β-cell survival. Diabetes Obes Metab. 2009;11:30–7.PubMedPubMedCentral
38.
Tran R, Moraes C, Hoesli CA. Controlled clustering enhances PDX1 and NKX6.1 expression in pancreatic endoderm cells derived from pluripotent stem cells. Sci Rep. Nature Publishing Group; 2020;10:1190.
39.
40.
Alejandro EU, Gregg B, Blandino-Rosano M, Cras-Méneur C, Bernal-Mizrachi E. Natural history of β-cell adaptation and failure in type 2 diabetes. Mol Aspects Med. 2015;42:19–41.PubMed
41.
Balakrishnan S, Dhavamani S, Prahalathan C. β-Cell specific transcription factors in the context of diabetes mellitus and β-cell regeneration. Mech Dev. 2020;163:103634.PubMed
42.
Kropp PA, Zhu X, Gannon M. Regulation of the pancreatic exocrine differentiation program and morphogenesis by onecut 1/Hnf6. Cell Mol Gastroenterol Hepatol. 2019;7:841–56.PubMedPubMedCentral
43.
Sheets TP, Park K-E, Park C-H, Swift SM, Powell A, Donovan DM, et al. Targeted mutation of NGN3 gene disrupts pancreatic endocrine cell development in pigs. Sci Rep. 2018;8:3582.PubMedPubMedCentral
44.
Jørgensen MC, de Lichtenberg KH, Collin CA, Klinck R, Ekberg JH, Engelstoft MS, et al. Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice. Development. 2018;145.
45.
Napolitano T, Avolio F, Courtney M, Vieira A, Druelle N, Ben-Othman N, et al. Pax4 acts as a key player in pancreas development and plasticity. Semin Cell Dev Biol. 2015;44:107–14.PubMed
46.
Heinis M, Simon MT, Duvillié B. New insights into endocrine pancreatic development: the role of environmental factors. Horm Res Paediatr. 2010;74:77–82.PubMedPubMedCentral
47.
Norouzirad R, González-Muniesa P, Ghasemi A. Hypoxia in obesity and diabetes: potential therapeutic effects of hyperoxia and nitrate. Oxid Med Cell Longev. 2017;2017:5350267.PubMedPubMedCentral
48.
Hatting M, Tavares CDJ, Sharabi K, Rines AK, Puigserver P. Insulin regulation of gluconeogenesis. Ann N Y Acad Sci. 2018;1411:21–35.PubMed
49.
Edgerton DS, Kraft G, Smith M, Farmer B, Williams PE, Coate KC, et al. Insulin’s direct hepatic effect explains the inhibition of glucose production caused by insulin secretion. JCI Insight. 2017;2:e91863.PubMedPubMedCentral
50.
Shi S, Koya D, Kanasaki K. Dipeptidyl peptidase-4 and kidney fibrosis in diabetes. Fibrogenesis Tissue Repair. 2016;9:1.PubMedPubMedCentral
51.
Gentilella R, Pechtner V, Corcos A, Consoli A. Glucagon-like peptide-1 receptor agonists in type 2 diabetes treatment: are they all the same? Diabetes Metab Res Rev. 2019;35:e3070.PubMed
52.
Kanasaki K. The role of renal dipeptidyl peptidase-4 in kidney disease: Renal effects of dipeptidyl peptidase-4 inhibitors with a focus on linagliptin. Clin Sci. 2018;132:489–507.
53.
Scheen AJ. Is there a role for alpha-glucosidase inhibitors in the prevention of type 2 diabetes mellitus? Drugs. 2003;63:933–51.PubMed
54.
Gupta D, Kono T, Evans-Molina C. The role of peroxisome proliferator-activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus. Diabetes Obes Metab. NIH Public Access; 2010;12:1036.
55.
Holst JJ, Vilsbøll T, Deacon CF. The incretin system and its role in type 2 diabetes mellitus. Mol Cell Endocrinol. 2009;297:127–36.PubMed
56.
Hodish I. Insulin therapy for type 2 diabetes - are we there yet? The d-Nav® story. Clin Diabetes Endocrinol. 2018;4:8.PubMedPubMedCentral
57.
Upadhyay J, Polyzos SA, Perakakis N, Thakkar B, Paschou SA, Katsiki N, et al. Pharmacotherapy of type 2 diabetes: an update. Metab Clin Exp. 2018;78:13–42.PubMed
58.
Ciążyńska M, Bednarski IA, Wódz K, Narbutt J, Lesiak A. NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis. Oncol Lett. 2020;19:1649–56.PubMedPubMedCentral
59.
Li D-X, Wang C-N, Wang Y, Ye C-L, Jiang L, Zhu X-Y, et al. NLRP3 inflammasome-dependent pyroptosis and apoptosis in hippocampus neurons mediates depressive-like behavior in diabetic mice. Behav Brain Res. 2020;391:112684.PubMed
60.
Reinehr T. Inflammatory markers in children and adolescents with type 2 diabetes mellitus. Clin Chim Acta. 2019;496:100–7.PubMed
61.
62.
Cimini FA, D’Eliseo D, Barchetta I, Bertoccini L, Velotti F, Cavallo MG. Increased circulating granzyme B in type 2 diabetes patients with low-grade systemic inflammation. Cytokine. 2019;115:104–8.PubMed
63.
Elimam H, Abdulla AM, Taha IM. Inflammatory markers and control of type 2 diabetes mellitus. Diabetes Metab Syndr. 2019;13:800–4.PubMed
64.
Jialal I, Chaudhuri A. Targeting inflammation to reduce ASCVD in type 2 diabetes. J Diabetes Complicat. 2019;33:1–3.
65.
66.
Liu H, Cao M, Wang Y, Li L, Zhu L, Xie G, et al. Endoplasmic reticulum stress is involved in the connection between inflammation and autophagy in type 2 diabetes. Gen Comp Endocrinol. 2015;210:124–9.PubMed
67.
68.
Lee CH, Ingrole RSJ, Gill HS. Generation of induced pluripotent stem cells using elastin like polypeptides as a non-viral gene delivery system. Biochim Biophys Acta Mol Basis Dis. 1866;2020:165405.
69.
70.
71.
72.
Rocha M, Apostolova N, Diaz-Rua R, Muntane J, Victor VM. Mitochondria and T2D: role of autophagy, ER stress, and inflammasome. Trends Endocrinol Metab. 2020.
73.
Fedele AO, Proud CG. Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signalling. Biosci Rep. 2020;40.
74.
Packer M. Interplay of adenosine monophosphate-activated protein kinase/sirtuin-1 activation and sodium influx inhibition mediates the renal benefits of sodium-glucose co-transporter-2 inhibitors in type 2 diabetes: a novel conceptual framework. Diabetes Obes Metab. 2020;22:734–42.PubMed
75.
Zummo FP, Cullen KS, Honkanen-Scott M, Shaw JAM, Lovat PE, Arden C. Glucagon-like peptide 1 protects pancreatic β-cells from death by increasing autophagic flux and restoring lysosomal function. Diabetes. 2017;66:1272–85.PubMed
76.
Xu C, Chen X, Sheng W-B, Yang P. Trehalose restores functional autophagy suppressed by high glucose. Reprod Toxicol. 2019;85:51–8.PubMedPubMedCentral
77.
Vivot K, Pasquier A, Goginashvili A, Ricci R. Breaking bad and breaking good: β-Cell autophagy pathways in diabetes. J Mol Biol. 2020;432:1494–513.PubMed
78.
Li J, Ye W, Xu W, Chang T, Zhang L, Ma J, et al. Activation of autophagy inhibits epithelial to mesenchymal transition process of human lens epithelial cells induced by high glucose conditions. Cell Signal. 2020;75:109768.PubMed
79.
Rezabakhsh A, Rahbarghazi R, Malekinejad H, Fathi F, Montaseri A, Garjani A. Quercetin alleviates high glucose-induced damage on human umbilical vein endothelial cells by promoting autophagy. Phytomedicine. 2019;56:183–93.PubMed
80.
Pinney SE, Simmons RA. Epigenetic mechanisms in the development of type 2 diabetes. Trends Endocrinol Metab. 2010;21:223–9.PubMed
81.
Ling C. Epigenetic regulation of insulin action and secretion - role in the pathogenesis of type 2 diabetes. J Intern Med. 2020;288:158–67.PubMed
82.
Ouni M, Saussenthaler S, Eichelmann F, Jähnert M, Stadion M, Wittenbecher C, et al. Epigenetic changes in islets of Langerhans preceding the onset of diabetes. Diabetes. American Diabetes Association; 2020;db200204.
83.
Celano M, Mio C, Sponziello M, Verrienti A, Bulotta S, Durante C, et al. Targeting post-translational histone modifications for the treatment of non-medullary thyroid cancer. Mol Cell Endocrinol. 2018;469:38–47.PubMed
84.
Demetriadou C, Koufaris C, Kirmizis A. Histone N-alpha terminal modifications: genome regulation at the tip of the tail. Epigenetics Chromatin. 2020;13:29.PubMedPubMedCentral
85.
86.
Lawrence M, Daujat S, Schneider R. Lateral thinking: how histone modifications regulate gene expression. Trends Genet. 2016;32:42–56.PubMed
87.
88.
Tessarz P, Kouzarides T. Histone core modifications regulating nucleosome structure and dynamics. Nat Rev Mol Cell Biol. 2014;15:703–8.PubMed
89.
Zhou K, Gaullier G, Luger K. Nucleosome structure and dynamics are coming of age. Nat Struct Mol Biol. Nature Publishing Group; 2019;26:3–13.
90.
Khullar M, Cheema BS, Raut SK. Emerging evidence of epigenetic modifications in vascular complication of diabetes. Front Endocrinol (Lausanne). 2017;8:237.
91.
92.
Donath MY, Dinarello CA, Mandrup-Poulsen T. Targeting innate immune mediators in type 1 and type 2 diabetes. Nat Rev Immunol. Nature Publishing Group. 2019;19:734–46.
93.
Bernstein D, Golson ML, Kaestner KH. Epigenetic control of β-cell function and failure. Diabetes Res Clin Pract. 2017;123:24–36.PubMed
94.
Gonzalez-Jaramillo V, Portilla-Fernandez E, Glisic M, Voortman T, Ghanbari M, Bramer W, et al. Epigenetics and inflammatory markers: a systematic review of the current evidence. Int J Inflam. 2019;2019:6273680.PubMedPubMedCentral
95.
Zhu H, Wang G, Qian J. Transcription factors as readers and effectors of DNA methylation. Nat Rev Genet. 2016;17:551–65.PubMedPubMedCentral
96.
Greenberg MVC, Bourc’his D. The diverse roles of DNA methylation in mammalian development and disease. Nat Rev Mol Cell Biol. Nature Publishing Group. 2019;20:590–607.
97.
de Mendoza A, Lister R, Bogdanovic O. Evolution of DNA methylome diversity in Eukaryotes. J Mol Biol. 2020;432:1687–705.
98.
Davegårdh C, García-Calzón S, Bacos K, Ling C. DNA methylation in the pathogenesis of type 2 diabetes in humans. Mol Metab. 2018;14:12–25.PubMedPubMedCentral
99.
Roshanzamir N, Hassan-Zadeh V. Methylation of specific CpG sites in IL-1β and IL1R1 genes is affected by hyperglycaemia in type 2 diabetic patients. Immunol Invest. Taylor & Francis; 2020;49:287–298.
100.
Willmer T, Johnson R, Louw J, Pheiffer C. Blood-based DNA methylation biomarkers for type 2 diabetes: Potential for clinical applications. Front Endocrinol (Lausanne). 2018;9:744.
101.
102.
An T, Zhang J, Ma Y, Lian J, Wu Y-X, Lv B-H, et al. Relationships of Non-coding RNA with diabetes and depression. Sci Rep. Nature Publishing Group; 2019;9:10707.
103.
Zhang J-R, Sun H-J. Roles of circular RNAs in diabetic complications: from molecular mechanisms to therapeutic potential. Gene. 2020;763:145066.PubMed
104.
Esteller M. Non-coding RNAs in human disease. Nat Rev Genet. 2011;12:861–74.PubMed
105.
106.
Eliasson L, Esguerra JLS. MicroRNA networks in pancreatic islet cells: normal function and type 2 diabetes. Diabetes. American Diabetes Association. 2020;69:804–12.
107.
Dahariya S, Paddibhatla I, Kumar S, Raghuwanshi S, Pallepati A, Gutti RK. Long non-coding RNA: classification, biogenesis and functions in blood cells. Mol Immunol. 2019;112:82–92.PubMed
108.
Hombach S, Kretz M. Non-coding RNAs: classification, biology and functioning. Adv Exp Med Biol. 2016;937:3–17.PubMed
109.
Motterle A, Gattesco S, Peyot M-L, Esguerra JLS, Gomez-Ruiz A, Laybutt DR, et al. Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes. Mol Metab. 2017;6:1407–18.PubMedPubMedCentral
110.
Lopez-Noriega L, Callingham R, Martinez-Sánchez A, Pizza G, Haberman N, Cvetesic N, et al. The long non-coding RNA Pax6os1/PAX6-AS1 modulates pancreatic β-cell identity and function. bioRxiv. Cold Spring Harbor Laboratory; 2020;2020.07.17.209015.
111.
Ji E, Kim C, Kim W, Lee EK. Role of long non-coding RNAs in metabolic control. Biochim Biophys Acta Gene Regul Mech. 1863;2020:194348.
112.
Reichelt-Wurm S, Wirtz T, Chittka D, Lindenmeyer M, Reichelt RM, Beck S, et al. Glomerular expression pattern of long non-coding RNAs in the type 2 diabetes mellitus BTBR mouse model. Sci Rep. Nature Publishing Group; 2019;9:9765.
113.
Zhu X, Li H, Wu Y, Zhou J, Yang G, Wang W. lncRNA MEG3 promotes hepatic insulin resistance by serving as a competing endogenous RNA of miR-214 to regulate ATF4 expression. Int J Mol Med. 2019;43:345–57.PubMed
114.
Arnes L, Akerman I, Balderes DA, Ferrer J, Sussel L. βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function. Genes Dev. 2016;30:502–7.PubMedPubMedCentral
115.
Kerry RG, Sahoo S, Das G, Patra JK. Theranostic application of nanoparticulated system: Present and future prospects. In: Inamuddin, Rangreez TA, Ahamed MI, Asiri AM, editors. Materials Research Forum [Internet]. Millersville, USA: Materials Research Foundation; 2019 [cited 2020 Sep 15]. p. 241–88. Available from: https://​www.​mrforum.​com/​product/​9781644900130-7/​
116.
Mandal B, Bhattacharjee H, Mittal N, Sah H, Balabathula P, Thoma LA, et al. Core-shell-type lipid-polymer hybrid nanoparticles as a drug delivery platform. Nanomedicine. 2013;9:474–91.PubMed
117.
Sengottaiyan A, Aravinthan A, Sudhakar C, Selvam K, Srinivasan P, Govarthanan M, et al. Synthesis and characterization of Solanum nigrum-mediated silver nanoparticles and its protective effect on alloxan-induced diabetic rats. J Nanostruct Chem. 2016;6:41–8.
118.
Afifi M, Abdelazim AM. Ameliorative effect of zinc oxide and silver nanoparticles on antioxidant system in the brain of diabetic rats. Asian Pac J Trop Biomed. 2015;5:874–7.
119.
Saratale RG, Shin HS, Kumar G, Benelli G, Kim D-S, Saratale GD. Exploiting antidiabetic activity of silver nanoparticles synthesized using Punica granatum leaves and anticancer potential against human liver cancer cells (HepG2). Artif Cells Nanomed Biotechnol. 2018;46:211–22.PubMed
120.
Kouame K, Peter AI, Akang EN, Moodley R, Naidu EC, Azu OO. Histological and biochemical effects of Cinnamomum cassia nanoparticles in kidneys of diabetic Sprague-Dawley rats. Bosn J Basic Med Sci. 2019;19:138–45.PubMedPubMedCentral
121.
Das G, Patra JK, Debnath T, Ansari A, Shin H-S. Investigation of antioxidant, antibacterial, antidiabetic, and cytotoxicity potential of silver nanoparticles synthesized using the outer peel extract of Ananas comosus (L.). PLoS ONE. 2019;14:e0220950.PubMedPubMedCentral
122.
Barathmanikanth S, Kalishwaralal K, Sriram M, Pandian SRK, Youn H-S, Eom S, et al. Anti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice. J Nanobiotechnol. 2010;8:16.
123.
Daisy P, Saipriya K. Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus. Int J Nanomedicine. 2012;7:1189–202.PubMedPubMedCentral
124.
Shilo M, Berenstein P, Dreifuss T, Nash Y, Goldsmith G, Kazimirsky G, et al. Insulin-coated gold nanoparticles as a new concept for personalized and adjustable glucose regulation. Nanoscale. 2015;7:20489–96.PubMed
125.
Ponnanikajamideen M, Rajeshkumar S, Vanaja M, Annadurai G. In vivo type 2 diabetes and wound-healing effects of antioxidant gold nanoparticles synthesized using the insulin plant Chamaecostus cuspidatus in albino rats. Can J Diabetes. 2019;43:82–89.e6.PubMed
126.
Manna K, Mishra S, Saha M, Mahapatra S, Saha C, Yenge G, et al. Amelioration of diabetic nephropathy using pomegranate peel extract-stabilized gold nanoparticles: assessment of NF-κB and Nrf2 signaling system. Int J Nanomedicine. 2019;14:1753–77.PubMedPubMedCentral
127.
Hussein S, El-Senosi YA, El-Dawy K, Baz H. Protective effect of zinc oxide nanoparticles on oxidative stress in experimental-induced diabetes in rats. Benha Vet Med J. 2014;27:405–14.
128.
Alkaladi A, Abdelazim AM, Afifi M. Antidiabetic activity of zinc oxide and silver nanoparticles on streptozotocin-induced diabetic rats. Int J Mol Sci. 2014;15:2015–23.PubMedPubMedCentral
129.
Afifi M, Almaghrabi OA, Kadasa NM. Ameliorative effect of zinc oxide nanoparticles on antioxidants and sperm characteristics in streptozotocin-induced diabetic rat testes. Biomed Res Int. 2015;2015:153573.PubMedPubMedCentral
130.
Nazarizadeh A, Asri-Rezaie S. Comparative study of antidiabetic activity and oxidative stress induced by zinc oxide nanoparticles and zinc sulfate in diabetic rats. AAPS PharmSciTech. 2016;17:834–43.PubMed
131.
El-Behery EI, El-Naseery NI, El-Ghazali HM, Elewa YHA, Mahdy EAA, El-Hady E, et al. The efficacy of chronic zinc oxide nanoparticles using on testicular damage in the streptozotocin-induced diabetic rat model. Acta Histochem. 2019;121:84–93.PubMed
132.
Kamel M, Khairy M, ELSadek N, Hussein M. Therapeutic efficacy of zinc oxide nanoparticles in diabetic rats. Slov Vet Res. 2019;56:187–94.
133.
Afify M, Samy N, Hafez NA, Alazzouni AS, Mahdy ES, El Mezayen HAE-M, et al. Evaluation of zinc-oxide nanoparticles effect on treatment of diabetes in streptozotocin-induced diabetic rats. Egypt J Chem. National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT; 2019;62:1771–83.
134.
Al-Quraishy S, Dkhil MA, Abdel Moneim AE. Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats. Int J Nanomedicine. 2015;10:6741–56.PubMedPubMedCentral
135.
Deng W, Xie Q, Wang H, Ma Z, Wu B, Zhang X. Selenium nanoparticles as versatile carriers for oral delivery of insulin: Insight into the synergic antidiabetic effect and mechanism. Nanomedicine. 2017;13:1965–74.PubMed
136.
Lin Y, Ren Y, Zhang Y, Zhou J, Zhou F, Zhao Q, et al. Protective role of nano-selenium-enriched Bifidobacterium longum in delaying the onset of streptozotocin-induced diabetes. R Soc Open Sci. 2018;5:181156.PubMedPubMedCentral
137.
Deng W, Wang H, Wu B, Zhang X. Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect. Acta Pharm Sin B. 2019;9:74–86.PubMed
138.
Abdulmalek SA, Balbaa M. Synergistic effect of nano-selenium and metformin on type 2 diabetic rat model: Diabetic complications alleviation through insulin sensitivity, oxidative mediators and inflammatory markers. PLoS ONE. 2019;14:e0220779.PubMedPubMedCentral
139.
Najafi R, Hosseini A, Ghaznavi H, Mehrzadi S, Sharifi AM. Neuroprotective effect of cerium oxide nanoparticles in a rat model of experimental diabetic neuropathy. Brain Res Bull. 2017;131:117–22.PubMed
140.
Shanker K, Naradala J, Mohan GK, Kumar GS, Pravallika PL. A sub-acute oral toxicity analysis and comparative in vivo anti-diabetic activity of zinc oxide, cerium oxide, silver nanoparticles, and Momordica charantia in streptozotocin-induced diabetic Wistar rats. RSC Adv. The Royal Society of Chemistry; 2017;7:37158–37167.
141.
142.
Zgheib C, Hilton SA, Dewberry LC, Hodges MM, Ghatak S, Xu J, et al. Use of cerium oxide nanoparticles conjugated with MicroRNA-146a to correct the diabetic wound healing impairment. J Am Coll Surg. 2019;228:107–15.PubMed
143.
Zgheib C, Hilton SA, Dewberry LC, Hodges MM, Ghatak S, Xu J, et al. Amelioration of diabetes-induced testicular and sperm damage in rats by cerium oxide nanoparticle treatment. J Am Coll Surg. 2019;228:107–15.PubMed
144.
Lopez-Pascual A, Urrutia-Sarratea A, Lorente-Cebrián S, Martinez JA, González-Muniesa P. Cerium oxide nanoparticles regulate insulin sensitivity and oxidative markers in 3T3-L1 adipocytes and C2C12 myotubes. Oxid Med Cell Longev. 2019;2019:2695289.PubMedPubMedCentral
145.
Andreani T, Miziara L, Lorenzón EN, de Souza ALR, Kiill CP, Fangueiro JF, et al. Effect of mucoadhesive polymers on the in vitro performance of insulin-loaded silica nanoparticles: Interactions with mucin and biomembrane models. Eur J Pharm Biopharm. 2015;93:118–26.PubMed
146.
Chen C, Zheng H, Xu J, Shi X, Li F, Wang X. Sustained-release study on Exenatide loaded into mesoporous silica nanoparticles: In vitro characterization and in vivo evaluation. Daru. 2017;25:20.PubMedPubMedCentral
147.
Mao C-F, Zhang X-R, Johnson A, He J-L, Kong Z-L. Modulation of diabetes mellitus-induced male rat reproductive dysfunction with micro-nanoencapsulated Echinacea purpurea ethanol extract. Biomed Res Int. 2018;2018:4237354.PubMedPubMedCentral
148.
Sudirman S, Hsu Y-H, Johnson A, Tsou D, Kong Z-L. Amelioration effects of nanoencapsulated triterpenoids from petri dish-cultured Antrodia cinnamomea on reproductive function of diabetic male rats. Int J Nanomedicine. 2018;13:5059–73.PubMedPubMedCentral
149.
Hou L, Zheng Y, Wang Y, Hu Y, Shi J, Liu Q, et al. Self-regulated carboxyphenylboronic acid-modified mesoporous silica nanoparticles with “Touch Switch” releasing property for insulin delivery. ACS Appl Mater Interfaces. 2018;10:21927–38.PubMed
150.
Hei M, Wu H, Fu Y, Xu Y, Zhu W. Phenylboronic acid functionalized silica nanoparticles with enlarged ordered mesopores for efficient insulin loading and controlled release. J Drug Deliv Sci Tec. 2019;51:320–6.
151.
Patiño-Herrera R, Louvier-Hernández JF, Escamilla-Silva EM, Chaumel J, Escobedo AGP, Pérez E. Prolonged release of metformin by SiO2 nanoparticles pellets for type II diabetes control. Eur J Pharm Sci. 2019;131:1–8.PubMed
152.
Hosseini A, Sharifzadeh M, Rezayat SM, Hassanzadeh G, Hassani S, Baeeri M, et al. Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy. Int J Nanomedicine. 2010;5:517–23.PubMedPubMedCentral
153.
Bal R, Türk G, Tuzcu M, Yilmaz O, Ozercan I, Kuloglu T, et al. Protective effects of nanostructures of hydrated C(60) fullerene on reproductive function in streptozotocin-diabetic male rats. Toxicology. 2011;282:69–81.PubMed
154.
Li X, Zhen M, Zhou C, Deng R, Yu T, Wu Y, et al. Gadofullerene nanoparticles reverse dysfunctions of pancreas and improve hepatic insulin resistance for type 2 diabetes mellitus treatment. ACS Nano. 2019;13:8597–608.PubMed
155.
Sá MA, Andrade VB, Mendes RM, Caliari MV, Ladeira LO, Silva EE, et al. Carbon nanotubes functionalized with sodium hyaluronate restore bone repair in diabetic rat sockets. Oral Dis. 2013;19:484–93.PubMed
156.
Ilie I, Ilie R, Mocan T, Tabaran F, Iancu C, Mocan L. Nicotinamide-functionalized multiwalled carbon nanotubes increase insulin production in pancreatic beta cells via MIF pathway. Int J Nanomedicine. 2013;8:3345–53.PubMedPubMedCentral
157.
Chen J, He P, Bai H, Lei H, Liu K, Dong F, et al. Novel phosphomolybdic acid/single-walled carbon nanohorn-based modified electrode for non-enzyme glucose sensing. J Electroanal Chem. 2017;784:41–6.
158.
Luan F, Zhang S, Chen D, Wei F, Zhuang X. Ni3S2/ionic liquid-functionalized graphene as an enhanced material for the nonenzymatic detection of glucose. Microchem J. 2018;143:450–6.
159.
Thangavel P, Kannan R, Ramachandran B, Moorthy G, Suguna L, Muthuvijayan V. Development of reduced graphene oxide (rGO)-isabgol nanocomposite dressings for enhanced vascularization and accelerated wound healing in normal and diabetic rats. J Colloid Interface Sci. 2018;517:251–64.PubMed
160.
Wang S, Zhao L, Xu R, Ma Y, Ma L. Facile fabrication of biosensors based on Cu nanoparticles modified as-grown CVD graphene for non-enzymatic glucose sensing. J Electroanal Chem. 2019;853:113527.
161.
Beyranvand S, Pourghobadi Z, Sattari S, Soleymani K, Donskyi I, Gharabaghi M, et al. Boronic acid functionalized graphene platforms for diabetic wound healing. Carbon. 2020;158:327–36.
162.
Balasubramani K, Sivarajasekar N, Naushad M. Effective adsorption of antidiabetic pharmaceutical (metformin) from aqueous medium using graphene oxide nanoparticles: Equilibrium and statistical modelling. J Mol Liq. 2020;301:112426.
163.
Das P, Maity PP, Ganguly S, Ghosh S, Baral J, Bose M, et al. Biocompatible carbon dots derived from κ-carrageenan and phenyl boronic acid for dual modality sensing platform of sugar and its anti-diabetic drug release behavior. Int J Biol Macromol. 2019;132:316–29.PubMed
164.
Ngo Y-LT, Choi WM, Chung JS, Hur SH. Highly biocompatible phenylboronic acid-functionalized graphitic carbon nitride quantum dots for the selective glucose sensor. Sensors Actuators B Chem. 2019;282:36–44.
165.
Du L, Li Z, Yao J, Wen G, Dong C, Li H-W. Enzyme free glucose sensing by amino-functionalized silicon quantum dot. Spectrochim Acta A Mol Biomol Spectrosc. 2019;216:303–9.PubMed
166.
Abazar F, Noorbakhsh A. Chitosan-carbon quantum dots as a new platform for highly sensitive insulin impedimetric aptasensor. Sensors Actuators B Chem. 2020;304:127281.
167.
Lee AC-L, Harris JL, Khanna KK, Hong J-H. A comprehensive review on current advances in peptide drug development and design. Int J Mol Sci. 2019;20.
168.
169.
Alghazzawi W, Danish E, Alnahdi H, Salam MA. Rapid microwave-assisted hydrothermal green synthesis of rGO/NiO nanocomposite for glucose detection in diabetes. Synthetic Metals. 2020;267:116401.
170.
Khan MS, Ameer H, Ali A, Li Y, Yang L, Ren X, et al. Electrochemiluminescence behaviour of silver/ZnIn2S4/reduced graphene oxide composites quenched by Au@SiO2 nanoparticles for ultrasensitive insulin detection. Biosens Bioelectron. 2020;162:112235.PubMed
171.
Lavanya N, Leonardi SG, Marini S, Espro C, Kanagaraj M, Reddy SL, et al. MgNi2O3 nanoparticles as novel and versatile sensing material for non-enzymatic electrochemical sensing of glucose and conductometric determination of acetone. J Alloys Compd. 2020;817:152787.
172.
Inyang A, Kibambo G, Palmer M, Cummings F, Masikini M, Sunday C, et al. One step copper oxide (CuO) thin film deposition for non-enzymatic electrochemical glucose detection. Thin Solid Films. 2020;709:138244.
173.
Damgé C, Socha M, Ubrich N, Maincent P. Poly(epsilon-caprolactone)/eudragit nanoparticles for oral delivery of aspart-insulin in the treatment of diabetes. J Pharm Sci. 2010;99:879–89.PubMed
174.
Oh KS, Kim JY, Yoon BD, Lee M, Kim H, Kim M, et al. Sol-gel transition of nanoparticles/polymer mixtures for sustained delivery of exenatide to treat type 2 diabetes mellitus. Eur J Pharm Biopharm. 2014;88:664–9.PubMed
175.
Song M, Wang H, Chen K, Zhang S, Yu L, Elshazly EH, et al. Oral insulin delivery by carboxymethyl-β-cyclodextrin-grafted chitosan nanoparticles for improving diabetic treatment. Artif Cells Nanomed Biotechnol. 2018;46:S774–82.PubMed
176.
Jamshidi M, Ziamajidi N, Khodadadi I, Dehghan A, Kalantarian G, Abbasalipourkabir R. The effect of insulin-loaded trimethylchitosan nanoparticles on rats with diabetes type I. Biomed Pharmacother. 2018;97:729–35.PubMed
177.
Shi Y, Sun X, Zhang L, Sun K, Li K, Li Y, et al. Fc-modified exenatide-loaded nanoparticles for oral delivery to improve hypoglycemic effects in mice. Sci Rep. 2018;8:726.PubMedPubMedCentral
178.
Abdel-Moneim A, El-Shahawy A, Yousef AI, Abd El-Twab SM, Elden ZE, Taha M. Novel polydatin-loaded chitosan nanoparticles for safe and efficient type 2 diabetes therapy: In silico, in vitro and in vivo approaches. Int J Biol Macromol. 2020;154:1496–504.PubMed
179.
Fang Y, Wang Q, Lin X, Jin X, Yang D, Gao S, et al. Gastrointestinal responsive polymeric nanoparticles for oral delivery of insulin: optimized preparation, characterization and in vivo evaluation. J Pharm Sci. 2019;108:2994–3002.PubMed
180.
El-Naggar ME, Al-Joufi F, Anwar M, Attia MF, El-Bana MA. Curcumin-loaded PLA-PEG copolymer nanoparticles for treatment of liver inflammation in streptozotocin-induced diabetic rats. Colloids Surf B Biointerfaces. 2019;177:389–98.PubMed
181.
Laddha UD, Kshirsagar SJ. Formulation of PPAR-gamma agonist as surface modified PLGA nanoparticles for non-invasive treatment of diabetic retinopathy: in vitro and in vivo evidences. Heliyon. 2020;6:e04589.PubMedPubMedCentral
182.
Arun G, Rajaram R, Kaleshkumar K, Gayathri N, Sivasudha T, Kandasamy S. Synergistic effect of novel chitosan combined metformin drug on streptozotocin-induced diabetes mellitus rat. Int J Biol Macromol. 2020;153:1335–49.PubMed
183.
Wong CY, Al-Salami H, Dass CR. Formulation and characterisation of insulin-loaded chitosan nanoparticles capable of inducing glucose uptake in skeletal muscle cells in vitro. J Drug Deliv Sci Technol. 2020;57:101738.
184.
Sarmento B, Martins S, Ferreira D, Souto EB. Oral insulin delivery by means of solid lipid nanoparticles. Int J Nanomedicine. 2007;2:743–9.PubMedPubMedCentral
185.
Sharma N, Rana S, Shivkumar HG, Sharma RK. Solid lipid nanoparticles as a carrier of metformin for transdermal delivery. Int J Drug Deliv. 2013;5:137–45.
186.
Choi JU, Lee SW, Pangeni R, Byun Y, Yoon I-S, Park JW. Preparation and in vivo evaluation of cationic elastic liposomes comprising highly skin-permeable growth factors combined with hyaluronic acid for enhanced diabetic wound-healing therapy. Acta Biomater. 2017;57:197–215.PubMed
187.
Pellegrino M, Ceccacci F, Petrini S, Scipioni A, De Santis S, Cappa M, et al. Exploiting novel tailored immunotherapies of type 1 diabetes: Short interfering RNA delivered by cationic liposomes enables efficient down-regulation of variant PTPN22 gene in T lymphocytes. Nanomedicine. 2019;18:371–9.PubMed
188.
Suzuki K, Kim KS, Bae YH. Long-term oral administration of Exendin-4 to control type 2 diabetes in a rat model. J Control Release. 2019;294:259–67.PubMed
189.
Ahad A, Raish M, Ahmad A, Al-Jenoobi FI, Al-Mohizea AM. Eprosartan mesylate loaded bilosomes as potential nano-carriers against diabetic nephropathy in streptozotocin-induced diabetic rats. Eur J Pharm Sci. 2018;111:409–17.PubMed
190.
Yücel Ç, Karatoprak GŞ, Aktaş Y. Nanoliposomal resveratrol as a novel approach to treatment of diabetes mellitus. J Nanosci Nanotechnol. 2018;18:3856–64.PubMed
191.
Ahangarpour A, Oroojan AA, Khorsandi L, Kouchak M, Badavi M. Solid lipid nanoparticles of myricitrin have antioxidant and antidiabetic effects on streptozotocin-nicotinamide-induced diabetic model and myotube cell of male mouse. Oxid Med Cell Longev. 2018;2018:7496936.PubMedPubMedCentral
192.
Cho EY, Ryu J-Y, Lee HAR, Hong SH, Park HS, Hong KS, et al. Lecithin nano-liposomal particle as a CRISPR/Cas9 complex delivery system for treating type 2 diabetes. J Nanobiotechnol. 2019;17:19.
193.
Khair R, Shende P, Kulkarni YA. Nanostructured polymer-based cochleates for effective transportation of insulin. J Mol Liq. 2020;311:113352.
194.
Shaveta S, Singh J, Afzal M, Kaur R, Imam SS, Alruwaili NK, et al. Development of solid lipid nanoparticle as carrier of pioglitazone for amplification of oral efficacy: formulation design optimization, in-vitro characterization and in-vivo biological evaluation. J Drug Deliv Sci Technol. 2020;57:101674.
195.
Karolczak K, Rozalska S, Wieczorek M, Labieniec-Watala M, Watala C. Poly(amido)amine dendrimers generation 4.0 (PAMAM G4) reduce blood hyperglycaemia and restore impaired blood-brain barrier permeability in streptozotocin diabetes in rats. Int J Pharm. 2012;436:508–18.PubMed
196.
Siewiera K, Labieniec-Watala M. Ambiguous effect of dendrimer PAMAM G3 on rat heart respiration in a model of an experimental diabetes - Objective causes of laboratory misfortune or unpredictable G3 activity? Int J Pharm. 2012;430:258–65.PubMed
197.
Labieniec-Watala M, Przygodzki T, Sebekova K, Watala C. Can metabolic impairments in experimental diabetes be cured with poly(amido)amine (PAMAM) G4 dendrimers? In the search for minimizing of the adverse effects of PAMAM administration. Int J Pharm. 2014;464:152–67.PubMed
198.
Akhtar S, Chandrasekhar B, Yousif MH, Renno W, Benter IF, El-Hashim AZ. Chronic administration of nano-sized PAMAM dendrimers in vivo inhibits EGFR-ERK1/2-ROCK signaling pathway and attenuates diabetes-induced vascular remodeling and dysfunction. Nanomedicine. 2019;18:78–89.PubMed
199.
Alam MS, Ahad A, Abidin L, Aqil M, Mir SR, Mujeeb M. Embelin-loaded oral niosomes ameliorate streptozotocin-induced diabetes in Wistar rats. Biomed Pharmacother. 2018;97:1514–20.PubMed
200.
Singhal T, Mohd M, Ahad A, Mohd A, Rahman SO, Najmi AK, et al. Preparation, optimization and biological evaluation of gymnemic acid loaded niosomes against streptozotocin-nicotinamide induced diabetic-nephropathy in Wistar rats. J Drug Deliv Sci Tec. 2019;54:101328.
201.
Alibolandi M, Mohammadi M, Taghdisi SM, Abnous K, Ramezani M. Synthesis and preparation of biodegradable hybrid dextran hydrogel incorporated with biodegradable curcumin nanomicelles for full thickness wound healing. Int J Pharm. 2017;532:466–77.PubMed
202.
Guo C, Li M, Qi X, Lin G, Cui F, Li F, et al. Intranasal delivery of nanomicelle curcumin promotes corneal epithelial wound healing in streptozotocin-induced diabetic mice. Sci Rep. 2016;6:29753.PubMedPubMedCentral
203.
Ravindran S, Suthar JK, Rokade R, Deshpande P, Singh P, Pratinidhi A, et al. Pharmacokinetics, metabolism, distribution and permeability of nanomedicine. Curr Drug Metab. 2018;19:327–34.PubMed
204.
Das S, Chaudhury A. Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS PharmSciTech. 2011;12:62–76.PubMed
205.
Sepúlveda-Crespo D, Ceña-Díez R, Jiménez JL, Ángeles M-FM. Mechanistic studies of viral entry: an overview of dendrimer-based microbicides as entry inhibitors against both HIV and HSV-2 overlapped infections. Med Res Rev. 2017;37:149–79.PubMed
206.
Xu B, Li A, Hao X, Guo R, Shi X, Cao X. PEGylated dendrimer-entrapped gold nanoparticles with low immunogenicity for targeted gene delivery. RSC Adv. The Royal Society of Chemistry; 2018;8:1265–1273.
207.
Talelli M, Barz M, Rijcken CJ, Kiessling F, Hennink WE, Lammers T. Core-crosslinked polymeric micelles: principles, preparation, biomedical applications and clinical translation. Nano Today. 2015;10:93–117.PubMedPubMedCentral
208.
Sun F, Wang S, Wang Y, Zhang J, Yu X, Zhou Y, et al. Synthesis of Ni-Co hydroxide nanosheets constructed hollow cubes for electrochemical glucose determination. Sensors (Basel). 2019;19.
209.
Mukherjee A, Waters AK, Kalyan P, Achrol AS, Kesari S, Yenugonda VM. Lipid-polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives. Int J Nanomedicine. 2019;14:1937–52.PubMedPubMedCentral
210.
Zhang C, Zhang R, Gao X, Cheng C, Hou L, Li X, et al. Small naked Pt nanoparticles confined in mesoporous shell of hollow carbon spheres for high-performance nonenzymatic sensing of H2O2 and glucose. ACS Omega. 2018;3:96–105.PubMedPubMedCentral
211.
Zhang J, Sun Y, Li X, Xu J. Fabrication of porous NiMn2O4 nanosheet arrays on nickel foam as an advanced sensor material for non-enzymatic glucose detection. Sci Rep. 2019;9:18121.PubMedPubMedCentral
212.
Ge Y, Lakshmipriya T, Gopinath SC, Anbu P, Chen Y, Hariri F, et al. Glucose oxidase complexed gold-graphene nanocomposite on a dielectric surface for glucose detection: a strategy for gestational diabetes mellitus. Int J Nanomedicine. 2019;14:7851–60.PubMedPubMedCentral
213.
Cui N, Guo P, Yuan Q, Ye C, Yang M, Yang M, et al. Single-step formation of Ni nanoparticle-modified graphene–diamond hybrid electrodes for electrochemical glucose detection. Sensors (Basel). 2019;19.
214.
Dai Z, Yang A, Bao X, Yang R. Facile non-enzymatic electrochemical sensing for glucose based on Cu2O–BSA nanoparticles modified GCE. Sensors (Basel). 2019;19.
215.
Zhu Q, Hu S, Zhang L, Li Y, Carraro C, Maboudian R, et al. Reconstructing hydrophobic ZIF-8 crystal into hydrophilic hierarchically-porous nanoflowers as catalyst carrier for nonenzymatic glucose sensing. Sensors Actuators B Chem. 2020;313:128031.
216.
Azharudeen AM, Karthiga R, Rajarajan M, Suganthi A. Fabrication, characterization of polyaniline intercalated NiO nanocomposites and application in the development of non-enzymatic glucose biosensor. Arab J Chem. 2020;13:4053–64.
217.
Ahmed HH, Abd El-Maksoud MD, Abdel Moneim AE, Aglan HA. Pre-clinical study for the antidiabetic potential of selenium nanoparticles. Biol Trace Elem Res. 2017;177:267–80.PubMed
218.
Bhattacharyya S, Kattel K, Kim F. Modulating the glucose transport by engineering gold nanoparticles. J Nanomedicine Biotherapeutic Discov. Longdom Publishing SL; 2016;6:141.
219.
Shaheen TI, El-Naggar ME, Hussein JS, El-Bana M, Emara E, El-Khayat Z, et al. Antidiabetic assessment; in vivo study of gold and core-shell silver-gold nanoparticles on streptozotocin-induced diabetic rats. Biomed Pharmacother. 2016;83:865–75.PubMed
220.
Singla R, Soni S, Patial V, Kulurkar PM, Kumari A, S M, et al. Cytocompatible anti-microbial dressings of Syzygium cumini cellulose nanocrystals decorated with silver nanoparticles accelerate acute and diabetic wound healing. Sci Rep. 2017;7:10457.
221.
Xiao Y, Wang X, Wang B, Liu X, Xu X, Tang R. Long-term effect of biomineralized insulin nanoparticles on type 2 diabetes treatment. Theranostics. 2017;7:4301–12.PubMedPubMedCentral
222.
Bhattacherjee A, Chakraborti AS. Argpyrimidine-tagged rutin-encapsulated biocompatible (ethylene glycol dimers) nanoparticles: Application for targeted drug delivery in experimental diabetes (Part 2). Int J Pharm. 2017;528:8–17.PubMed
223.
Maestrelli F, Mura P, González-Rodríguez ML, Cózar-Bernal MJ, Rabasco AM, Di Cesare ML, et al. Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus. Int J Pharm. 2017;530:430–9.PubMed
224.
Shi G, Chen W, Zhang Y, Dai X, Zhang X, Wu Z. An antifouling hydrogel contained silver nanoparticles for modulating therapeutic immune response in chronic wound healing. Langmuir. 2019;35:1837–45.PubMed
225.
Pham TT, Nguyen TT, Pathak S, Regmi S, Nguyen HT, Tran TH, et al. Tissue adhesive FK506-loaded polymeric nanoparticles for multi-layered nano-shielding of pancreatic islets to enhance xenograft survival in a diabetic mouse model. Biomaterials. 2018;154:182–96.PubMed
226.
Chinnaiyan SK, Deivasigamani K, Gadela VR. Combined synergetic potential of metformin loaded pectin-chitosan biohybrids nanoparticle for NIDDM. Int J Biol Macromol. 2019;125:278–89.PubMed
227.
Tong F, Chai R, Jiang H, Dong B. In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles. Int J Nanomed. 2018;13:1945–62.
228.
Shalaby TI, El-Refaie WM. Bioadhesive chitosan-coated cationic nanoliposomes with improved insulin encapsulation and prolonged oral hypoglycemic effect in diabetic mice. J Pharm Sci. 2018;107:2136–43.PubMed
229.
Mukhopadhyay P, Maity S, Mandal S, Chakraborti AS, Prajapati AK, Kundu PP. Preparation, characterization and in vivo evaluation of pH sensitive, safe quercetin-succinylated chitosan-alginate core-shell-corona nanoparticle for diabetes treatment. Carbohydr Polym. 2018;182:42–51.PubMed
230.
Mumuni MA, Kenechukwu FC, Ofokansi KC, Attama AA, Díaz DD. Insulin-loaded mucoadhesive nanoparticles based on mucin-chitosan complexes for oral delivery and diabetes treatment. Carbohydr Polym. 2020;229:115506.PubMed
231.
Uma Suganya KS, Govindaraju K, Veena Vani C, Premanathan M, Ganesh Kumar VK. In vitro biological evaluation of anti-diabetic activity of organic-inorganic hybrid gold nanoparticles. IET Nanobiotechnol. 2019;13:226–9.PubMed
232.
Ansari S, Bari A, Ullah R, Mathanmohun M, Veeraraghavan VP, Sun Z. Gold nanoparticles synthesized with Smilax glabra rhizome modulates the anti-obesity parameters in high-fat diet and streptozotocin induced obese diabetes rat model. J Photochem Photobiol B Biol. 2019;201:111643.
233.
Chauhan P, Mahajan S, Prasad GBKS. Preparation and characterization of CS-ZnO-NC nanoparticles for imparting anti-diabetic activities in experimental diabetes. J Drug Deliv Sci Tec. 2019;52:738–47.
234.
He Z, Hu Y, Gui Z, Zhou Y, Nie T, Zhu J, et al. Sustained release of exendin-4 from tannic acid/Fe (III) nanoparticles prolongs blood glycemic control in a mouse model of type II diabetes. J Control Release. 2019;301:119–28.PubMed
235.
Panda BP, Krishnamoorthy R, Bhattamisra SK, Shivashekaregowda NKH, Seng LB, Patnaik S. Fabrication of second generation smarter PLGA based nanocrystal carriers for improvement of drug delivery and therapeutic efficacy of gliclazide in type-2 diabetes rat model. Sci Rep. 2019;9:17331.PubMedPubMedCentral
236.
Yang B-Y, Hu C-H, Huang W-C, Ho C-Y, Yao C-H, Huang C-H. Effects of bilayer nanofibrous scaffolds containing curcumin/lithospermi radix extract on wound healing in streptozotocin-induced diabetic rats. Polymers (Basel). 2019;11.
237.
Wu J-Z, Yang Y, Li S, Shi A, Song B, Niu S, et al. Glucose-sensitive nanoparticles based on poly (3-acrylamidophenylboronic acid-block-nvinylcaprolactam) for insulin delivery. Int J Nanomedicine. 2019;14:8059–72.PubMedPubMedCentral
238.
Nikpasand A, Parvizi MR. Evaluation of the effect of titatnium dioxide nanoparticles/gelatin composite on infected skin wound healing; an animal model study. Bull Emerg Trauma. 2019;7:366–72.PubMedPubMedCentral
239.
Natarajan J, Sanapalli BKR, Bano M, Singh SK, Gulati M, Karri VVSR. Nanostructured lipid carriers of pioglitazone loaded collagen/chitosan composite scaffold for diabetic wound healing. Adv Wound Care (New Rochelle). 2019;8:499–513.
240.
Mudassir J, Darwis Y, Muhamad S, Khan AA. Self-assembled insulin and nanogels polyelectrolyte complex (Ins/NGs-PEC) for oral insulin delivery: characterization, lyophilization and in-vivo evaluation. Int J Nanomedicine. 2019;14:4895–909.PubMedPubMedCentral
241.
Samadian H, Zamiri S, Ehterami A, Farzamfar S, Vaez A, Khastar H, et al. Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: In vitro and in vivo studies. Sci Rep. Nature Publishing Group; 2020;10:8312.
242.
Pouran SR, Bayrami A, Mohammadi Arvanag F, Habibi-Yangjeh A, Darvishi Cheshmeh Soltani R, Singh R, et al. Biogenic integrated ZnO/Ag nanocomposite: surface analysis and in vivo practices for the management of type 1 diabetes complications. Colloids Surf B Biointerfaces. 2020;189:110878.
243.
Golmohammadi R, Najar-Peerayeh S, Tohidi Moghadam T, Hosseini SMJ. Synergistic antibacterial activity and wound healing properties of selenium-chitosan-mupirocin nanohybrid system: An in vivo study on rat diabetic Staphylococcus aureus wound infection model. Sci Rep. Nature Publishing Group; 2020;10:2854.
244.
Robkhob P, Ghosh S, Bellare J, Jamdade D, Tang I-M, Thongmee S. Effect of silver doping on antidiabetic and antioxidant potential of ZnO nanorods. J Trace Elem Med Biol. 2020;58:126448.PubMed
245.
He Z, Nie T, Hu Y, Zhou Y, Zhu J, Liu Z, et al. A polyphenol-metal nanoparticle platform for tunable release of liraglutide to improve blood glycemic control and reduce cardiovascular complications in a mouse model of type II diabetes. J Control Release. 2020;318:86–97.PubMed
246.
Mussmann R, Geese M, Harder F, Kegel S, Andag U, Lomow A, et al. Inhibition of GSK3 promotes replication and survival of pancreatic beta cells. J Biol Chem. 2007;282:12030–7.PubMed
247.
Frudd K, Burgoyne T, Burgoyne JR. Oxidation of Atg3 and Atg7 mediates inhibition of autophagy. Nat Commun. 2018;9:95.PubMedPubMedCentral
248.
Ji J, Petropavlovskaia M, Khatchadourian A, Patapas J, Makhlin J, Rosenberg L, et al. Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in β-cells. J Cell Mol Med. 2019;23:2890–900.PubMedPubMedCentral
249.
Akter R, Cao P, Noor H, Ridgway Z, Tu L-H, Wang H, et al. Islet amyloid polypeptide: structure, function, and pathophysiology. J Diabetes Res. 2016;2016:2798269.PubMed
250.
Mukherjee A, Morales-Scheihing D, Butler PC, Soto C. Type 2 diabetes as a protein misfolding disease. Trends Mol Med. 2015;21:439–49.PubMedPubMedCentral
251.
Kulas JA, Franklin WF, Smith NA, Manocha GD, Puig KL, Nagamoto-Combs K, et al. Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues. Am J Physiol Endocrinol Metab. 2019;316:E106–20.PubMed
252.
Grimm MOW, Mett J, Stahlmann CP, Haupenthal VJ, Zimmer VC, Hartmann T. Neprilysin and Aβ clearance: impact of the APP intracellular domain in NEP regulation and implications in Alzheimer’s disease. Front Aging Neurosci. 2013;5:98.PubMedPubMedCentral
253.
Zhang M, Cai F, Zhang S, Zhang S, Song W. Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer’s progression in vivo. Sci Rep. 2014;4:7298.PubMedPubMedCentral
254.
Kim J, Lim Y-M, Lee M-S. The role of autophagy in systemic metabolism and human-type diabetes. Mol Cells. 2018;41:11–7.PubMedPubMedCentral
255.
Matsumoto G, Inobe T, Amano T, Murai K, Nukina N, Mori N. N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression. Sci Rep. 2018;8:9585.PubMedPubMedCentral
256.
Sikanyika NL, Parkington HC, Smith AI, Kuruppu S. Powering amyloid beta degrading enzymes: a possible therapy for Alzheimer’s Disease. Neurochem Res. 2019;44:1289–96.PubMed
257.
Pierzynowska K, Podlacha M, Gaffke L, Majkutewicz I, Mantej J, Węgrzyn A, et al. Autophagy-dependent mechanism of genistein-mediated elimination of behavioral and biochemical defects in the rat model of sporadic Alzheimer’s disease. Neuropharmacol. 2019;148:332–46.
258.
Elliott HR, Shihab HA, Lockett GA, Holloway JW, McRae AF, Smith GD, et al. Role of DNA Methylation in type 2 diabetes etiology: using genotype as a causal anchor. Diabetes. 2017;66:1713–22.PubMedPubMedCentral
259.
Smail HO. The epigenetics of diabetes, obesity, overweight and cardiovascular disease. AIMS Genet. 2019;6:36–45.PubMedPubMedCentral
260.
Pordzik J, Jakubik D, Jarosz-Popek J, Wicik Z, Eyileten C, De Rosa S, et al. Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review. Cardiovasc Diabetol. 2019;18:113.PubMedPubMedCentral
Metadaten
Titel
Molecular prospect of type-2 diabetes: Nanotechnology based diagnostics and therapeutic intervention
verfasst von
Rout George Kerry
Gyana Prakash Mahapatra
Ganesh Kumar Maurya
Sushmita Patra
Subhasis Mahari
Gitishree Das
Jayanta Kumar Patra
Sabuj Sahoo
Publikationsdatum
14.10.2020
Verlag
Springer US
Schlagwörter
Insulins
Birth
Insulins
Erschienen in
Reviews in Endocrine and Metabolic Disorders / Ausgabe 2/2021
Print ISSN: 1389-9155
Elektronische ISSN: 1573-2606
DOI
https://doi.org/10.1007/s11154-020-09606-0

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