Methods/Design
A field trial with one intervention and one comparison group, with ex ante and ex post measurements will be conducted in two IMSS primary care clinics in Mexico City. The clinics will be selected for convenience; each clinic must have more than 20 family doctors' offices and available space for the intervention (consulting room and an area for group counseling) and should have accepted to participate in the study; The intervention will be conducted in one clinic and the other clinic will serve as a comparison group, where the usual care for climacteric stage women will be observed.
The study population will consist of women affiliated with IMSS, between 45 and 59 years of age with a maximum of 5 years after menopause. The women should be users of the clinic, and should not have mental conditions that would prevent them from understanding the information or from taking independent decisions (dementia, mental retardation or psychosis), a physical disability that would impede them from participating (hearing loss, diseases affecting physical mobility as severe forms of rheumatoid arthritis), medical diagnosis of depression, diabetes mellitus, hypertension, renal or liver failure, and/or cancer, because patients with these diseases require specific care provided by several specialists. All women must agree to participate in the study through written informed consent.
The project was authorized by the National Research and Ethics Committee of the IMSS.
Preparation of the intervention
In both intervention and control clinics the project will be presented to healthcare providers.
A healthcare team will implement the intervention comprised of family doctors, two nurses (one for each working shift) and a psychologist. The nurses and the psychologist will be selected from those with clinical experience in providing care to climacteric stage women; they will be previously trained by researchers and will work specifically in this project. The training will include theory and practice, and will last 60 hours based on a "training guide" that was developed ex profeso. The training topics include: 1) Health needs of climacteric stage women; 2) Risk factors for chronic diseases during the climacteric stage and self-care-related activities; 3) Health behaviors, self-efficacy, knowledge regarding climacteric stage and health-related self-care activities and empowerment; 4) Cognitive restructuring and problem solving, self-esteem and communication; 5) Healthy diet enriched with fruits, vegetables and milk products; 6) Regular leisure time with physical activity; 7) Individual counseling from the empowerment approach. Self-care plan: goal setting, action planning, monitoring and achievement of health goals; 8) Group counseling from the empowerment; 9) Integrative health care model for women at the climacteric stage.
All family doctors working in the intervention clinic will be invited to participate in the study. Family doctors, who agree to collaborate, will participate in a training course that consists in reviewing and discussing the proposed model, the roles and responsibilities of health providers involved in the care of climacteric stage women within IHCM. The researchers will deliver this course that will last two sessions of 60 minutes each.
Description of the intervention
The IHCM with an empowerment approach will address the care that should be given collaboratively by the health team in cooperation with the active participation of women. The IHCM will be provided under the leadership of the nurse who will coordinate with the health team members, promote preventive care, and incorporate cognitive-behavioral strategies, such as individual and group counseling. The IHCM will be provided for three months to each woman, followed by a three-month follow-up. The empowerment of women will work to facilitate women's recognition of their actual or potential health problems, enable them to solve these problems by drawing up an action plan to improve or maintain their health, and develop their autonomous health-related self-care skills.
In the control group, women will continue the usual healthcare consisting of curative care provided by their family doctor and preventive care according to the IMSS prevention programs focused on this age group (chronic disease screening) and provided by nurses according to the women's demand.
Recruitment of women and consultation with the family doctor
In both working shifts (morning and afternoon) family doctors will identify and evaluate those women who meet the inclusion criteria. Family doctors should provide preventive and curative healthcare services, according to womens' individual health needs, and send the candidates to the waiting room where they will be interviewed by study interviewers, who will explain the purpose and content of the study, and obtain the signed informed consent from those women who agree to participate. Once the participant is included in the study, the interviewer will perform the base-line interview then send the woman to the nurse of the study.
Individual counseling by nurse
Nurses will provide monthly individual counseling to each woman based on the empowerment approach (the first visit being 40 to 60 minutes with subsequent counseling sessions of 20 to 30 minutes). The individual counseling will include the following contents (Table
2): 1) the nurse and the woman collaboratively evaluating the current status of the participant (physical, emotional, cognitive and so forth) within their social environment; 2) the nurse facilitating the women's recognition of her personal health risks and responsibilities for health-related self-care; 3) and 4) the nurse guiding the woman in setting her health goals and laying out a feasible action plan for her health-related self-care, thereby promoting the empowerment of each participant; and 5) the nurse and the woman collaboratively monitoring the progress of the action plan.
Table 2
Individual counseling for climacteric stage women
1) Evaluation of the current status of women (physical, emotional, cognitive, etc.) within their social environment | • The nurse and the woman collaboratively assess the woman's health and health-related self-care practices (diet, leisure time physical activity, use of screening services). |
| • The nurse provides relevant information on climacteric self-care: a) explains the definition of the climacteric stage and menopause and health problems the woman may experience during and after the climacteric stage; b) describe the factors (activities) that cause or protect against the occurrence of such problems; c) answers the woman's questions. |
2) Facilitation of the woman's recognition of her personal health risks and responsibility for health-related self-care | • The nurse guides women on specific personal health-related values, beginning with the question: What health would you like to have in the next 10 years? |
3 and 4) Guidance on the health-related goal setting and elaboration of a feasible action plan for women's self-care | • The nurse guides women to choose their personal health-related self-care goals. |
| • The nurse guides women to choose strategies/actions to overcome barriers, using the problem-solving model. |
| • The nurse facilitates the agreement of women to carry out the action plan. |
| • The nurse and women jointly assess the level of womens' self-efficacy regarding the achievement of the agreed actions (on a scale of 0 to 10). |
5) Monitoring of the progress of the action plan | The nurse and women jointly: |
| • Evaluate progress in achieving the health-related goals and specific actions for development and maintenance of healthy behaviors. |
| • Resolve problems related to barriers for implementing the action plan, translating such barriers in the "learned lessons." |
The nurse will also schedule appointments for individual and group counseling and refer the woman to the psychologist and to the family doctor, who will provide comprehensive and continuous care consistent with the personal health needs of each participant.
Individual counseling by the psychologist
Psychological counseling will be based on the Rational Emotive Behavioral Therapy and its central concept ABC [
42]. According to this concept, emotional and behavioral consequences (C) are the result of beliefs (B) on activating events (A). The psychologist and the woman will collaboratively evaluate and restructure the woman's erroneous beliefs about the climacteric stage and her emotional resources, which refer to the ability to positively guide the emotions to achieve a better level of self-esteem and self-efficacy. The psychologist and the woman will define the number of consultations required in accordance to her individual needs and characteristics.
Group counseling
All women of the intervention group will be invited to eight weekly, 90-minutes group sessions to facilitate and enhance their knowledge about menopause and their care, as well as to share experiences, concerns and motivations, with other women. Each group session will be coordinated by the nurse or psychologist of the study and will include five to ten women. The group sessions will focus on common educational needs. Both individual and group counseling will be supported by printed material developed ex profeso, which participants will be encouraged to keep as a source of information.
The main themes of group sessions will be: 1) the climacteric stage and the empowerment approach; 2) Emotional well-being, self-esteem and self-efficacy during menopause; 3) Factors that predispose chronic disease development during the climacteric stage and health-related self-care strategies; 4) Physical activity: barriers, benefits, type, frequency and recommended time. How to establish an individual action plan on physical activity and make it feasible (problem solving); 5) Healthy diet during the climacteric stage including increase of intake of fruits, vegetables and dairy products on a daily basis, as well as education about the barriers to and benefits of a healthy diet. How to establish an individual action plan toward a healthy diet and make it feasible; 6-8) Monitoring of the progress of women's action plans. Participants should attend to group sessions one to five, and to sessions six to eight can attend either as a group or individually.
Data collection
Information on the study variables will be collected on three occasions: when the woman enters to the study (baseline), once intervention is complete (at three months) and after three more months of follow-up (six months).
Study variables
The main outcome variables will be:
Health-related quality of life (HR-QoL), which will be measured with the revised version of Women's Health Questionnaire (WHQ23) [
43]. This is a specific questionnaire for women in perimenopause, menopause and post menopause stages, that comprises six domains: anxiety/depression, well-being, somatic symptoms, memory/concentration, vasomotor symptoms and sleep problems. The WHQ23 also has two optional domains: sexual behavior and menstrual symptoms, which will apply only to women who are sexually active or who have menstrual periods. The highest value for each domain score is 100, which means high HR-QoL, and the lowest is 0, which means low HR-QoL.
Other outcome variables will be:
1) Empowerment of women in relation to their self-care measured by the empowerment scale, which was modified from the diabetes empowerment short scale [
44] to be used in climacteric women. The maximum score of empowerment is 5, the minimum is 1.
2) Self-efficacy of women in relation to menopause and its care will be assessed with Perimenopausal Health Self-efficacy Scale (PHS-ES) which consists of 23 items [
45]. The maximum score of PHS-ES is 207 (high self-efficacy) and the minimum is 23 (low self-efficacy).
3) Women's knowledge about the climacteric stage will be estimated with a questionnaire developed ex profeso. The questionnaire consists of 24 items that assess the following aspects: what is the climacteric stage, what are climacteric symptoms and health risks, and how can they be prevented during the climacteric stage. The minimum score on the scale corresponds to -24 points (without knowledge) and the maximum 24 points (full knowledge).
4) The use of screening services for: a) breast cancer by mammography in the last two years; b) cervical cancer by Pap-test in the last three years in women without a history of total hysterectomy; c) diabetes by measuring fasting plasma glucose in the last three years; d) hypertension: by measuring the systolic and diastolic blood pressure in the last year. The use of screening services will be estimated as the sum of the number of screening services that women used, divided by the total number of screening services recommended according to IMSS regulations and multiplied by 100.
5) Percentage of women who practice regular leisure time physical activity (PA), where regular was defined as moderate intensity if done for ≥150 minutes/week or vigorous intensity if done ≥75 minutes/week.
6) Percentage of women who practice a healthy diet, which included the daily consumption of fruits (3-4 servings), vegetables (4-5 servings), and dairy products (2-3 servings).
The covariates will be:
a) Women's general characteristics: Age, schooling, marital and employment status.
b) Smoking status and alcohol consumption. Smoking status will consider former and current smokers and will register the number of cigarettes actually smoked per day. Alcohol consumption will be classified as non-drinkers (never drink alcohol), occasional drinkers (drink rarely or less than once a week), moderate drinkers (from 1 to 14 drinks per week) and heavy drinkers (more than 14 drinks per week).
c) Nutritional status will be measured by body mass index (BMI) and classified into groups of normal weight (BMI of 18.5-24.9 kg/m2), overweight (BMI of 25.0 to 29.9 kg/m2), or obese (BMI ≥30.0 kg/m2).
d) Social support (SS) will be measured by applying the DUKE-UNC-11 questionnaire [
46]. This questionnaire evaluates confidential SS (possibility of having people to communicate with) with a minimum score of 7 points (low confidential SS) and a maximum score of 35 points (high confidential SS); and affective SS (demonstration of love, affection, and empathy) with a minimum score of 4 (low affective SS) and a maximum score of 20 points (high affective SS).
e) Medical and reproductive history: Presence of chronic diseases, number of pregnancies and living children, and menopause (one year after the last menstrual period). Type of menopause will be classified as natural or surgical, age at onset of menopause; time elapsed since menopause, presence and type of climacteric symptoms, and number of visits with the family doctor or other health provider in the last three months. The severity of vasomotor symptoms and vaginal atrophy symptoms is classified using the criteria proposed by the Department of Health and Human Services Food and Drug Administration [
47], which are based upon women's self-report, and define the symptoms as mild, moderate, or severe.
f) Satisfaction with care received at the FMC will be measured with the general question of how satisfied are you with the care you have received at the clinic? The possible answers are very satisfied, satisfied, neither satisfied nor unsatisfied, unsatisfied, and very unsatisfied.
g) Women's self-esteem will be measured with the Rosenberg Self-Esteem Scale (EAR) [
48,
49]. It is a one-domain instrument that consists of 10 questions. The highest score is 30 (high self-esteem) and the lowest is 0 (low self-esteem).
h) Adherence to MAIMC will be defined when the woman attends at least 60% of the planned individual and group counseling sessions.
Sample size
The sample size for the primary outcome (HR-QoL) was estimated by using the formula to test change in the mean of two normally distributed samples in longitudinal studies [
50]. An average increase of at least 10 points in one or more domains of WHQ23 in the intervention group compared with control group women was considered to be clinically relevant. The assumptions included: a mean HR-QoL score of 64.9 points (standard deviation of 23.4 points) in the domain of general well-being [
51], α = 0.05 (for one-sided hypothesis) and β = 0.20. The number of women by group, assuming a drop-out rate of 20% will be 107.
We also estimated a sample size for regular leisure time physical activity considering that this is the outcome variable more difficult to achieve. It was assumed that only 17% of women in Mexico engaged in some type of regular leisure time physical activity [
11] and a positive increase of at least 10% will be achieved after women participation in the IHCM. For this calculation, we used the formula to test the difference of proportions between two populations [
50] with a = 0.05 (one side) and the power of 80%. The total number of women by group to include assuming a drop-out rate of 20% will be 207.
Statistical analysis
The women characteristics of each intervention and comparison groups will be compared by using the Chi-square test to ascertain whether the groups were equivalent.
The effects of intervention for categorical outcome variables (regular leisure time physical activity, healthy diet) will be measured by comparing the baseline and post-intervention evaluation stages for differences in these variables using Chi-square test. Absolute percentage differences and corresponding 95% confidence intervals will be calculated.
Scores for the HR-QoL on the WHQ23 scale, the self-efficacy on the PHS-ES scale, the empowerment on the short form scale, knowledge about the climacteric stage, and menopause and self-care-related activities will be calculated according to the scoring algorithms. Measures of central tendency and distribution will be examined for these variables at the different measurement periods. The differences in the baseline and post-intervention stages for outcome variables will be compared within each group, and differences between the groups will be compared using the differences-in-differences (D-in-D) estimator [
52]. The generalized linear model (GLM) will be used to assess changes in the main outcome variable controlling for baseline measures and other study variables as covariates. The GLM methods allow for modeling the correlation of the repeated observations on the same subjects [
53].
The p value <0.05 will be considered as statistically significant. The analysis will be performed with the Stata 11.0 statistical software (Stata 11.0, Stata Corp; College Station, TX).
Discussion
In primary care services, it is essential to provide a source of care that has continuity and coordination, and comprehensively covers the health needs of people. The constraints resulting from limited resources and restrictive organizational characteristics of institutionalized healthcare allows a limited range of changes, and these circumstances promote that innovative healthcare models should be carefully designed and evaluated to demonstrate healthcare service relevance and feasibility. Relevance, in this case, refers to meeting the health needs of climacteric stage women and to demonstrating its potential benefit. Feasibility means that the new model of care is applicable in the local context. An integrative health care model (bio-psycho-social, multidisciplinary and women-centered) with the empowerment approach may be a better alternative to ensure that women engage in their self-care and understand its importance to their present and future health and quality of life. The evaluation of the effectiveness of this research-based model can guide the feasibility of extending it into an operational model through a specific program.
The possible limitations of the study may include the following:
It was decided to perform the intervention in one clinic, taking another as a control to prevent women from both groups from communicating and transmitting information between them. However, the implementation of the study in two clinics may result in difference baseline characteristics of women in both groups. To overcome this limitation in the data analysis step, the regression methods will be used to adjust the results of the study for possible differences between groups.
Furthermore, the baseline evaluation can affect women in the control group resulting in them seeking counseling regarding the climacteric stage, attending screening programs, and changing their lifestyles.
The request for voluntary collaboration of family doctors and women could result in better doctors and women with healthier lifestyles agreeing to participate. Previous studies have reported that patients with unhealthy lifestyles are usually reluctant to participate. To confirm or disregard this limitation we will apply a short list of questions about the general characteristics and lifestyles to women who do not agree to participate in the study.
Compliance with the leisure time physical activity and healthy diet will be assessed through self-reporting of women unable to verify their actual practice, and will possibly overestimate the effect of the intervention regarding these variables.
Due to budgetary restrictions it is not possible to plan a long-term follow-up (12 months of study) of the IHCM impact.
Due to the financial and organizational feasibility, the study will be tested only in the population covered by IMSS, therefore, we can not say that this strategy would have the same results in women affiliated with other health institutions in Mexico, or women who receive healthcare from the Ministry of Health. However, we expect that the results of this study can be implemented in other institutions, with some necessary adaptations.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
SVD designed the study, educational materials and the training program, also wrote the paper. PEA contributed in the study design, development of the educational materials and the training program, also reviewed critically the manuscript. SFH contributed in the plan for the statistical analysis and reviewed critically the manuscript. CI contributed in the study design and reviewed critically the manuscript. RPC contributed in the study design and reviewed critically the manuscript. All authors read and approved the final manuscript.