Erschienen in:
01.12.1999 | Paper Report
Interaction of BRCA1 and AR genes in breast cancer risk
verfasst von:
Alison Dunning
Erschienen in:
Breast Cancer Research
|
Ausgabe 1/1999
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Excerpt
Germline mutations in BRCA1 confer Mendelian inheritance of breast cancer in carrier families, but there remain large differences in age-at-onset of the cancer, which might be explained by modifier genes. Genes in the steroid hormone pathways are strong candidates for being such modifiers. Among these, androgen receptor (AR) gene expression is known to affect breast tumor growth and progression. The AR gene has an expressed CAG repeat polymorphism which alters the length of a glutamine tract in the protein and is inversely related to the transactivation efficiency of the AR signalling system. …