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Seminars in Immunopathology

Erschienen in:

08.10.2020 | Review

Interactions among microbes, the immune system, and the circadian clock

verfasst von: John F. Brooks II, Lora V. Hooper

Erschienen in: Seminars in Immunopathology | Ausgabe 6/2020

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Abstract

The circadian clock couples physiological processes and behaviors to environmental light cycles. This coupling ensures the synchronization of energetically expensive processes to the time of day at which an organism is most active, thus improving overall fitness. Host immunity is an energetically intensive process that requires the coordination of multiple immune cell types to sense, communicate, and respond to a variety of microorganisms. Interestingly the circadian clock entrains immune cell development, function, and trafficking to environmental light cycles. This entrainment results in the variation of host susceptibility to microbial pathogens across the day-night cycle. In addition, the circadian clock engages in bi-directional communication with the microbiota, resident microorganisms that reside in proximity to the epithelial surfaces of animals. This bi-directional interchange plays an essential role in regulating host immunity and is also pivotal for the circadian control of metabolism. Here, we review the role of the circadian clock in directing host immune programs and consider how commensal and pathogenic microbes impact circadian physiological processes.

Asher G, Sassone-Corsi P (2015) Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock. Cell 161:84–92. https://doi.org/10.1016/j.cell.2015.03.015CrossRefPubMed

Shultzaberger RK, Boyd JS, Diamond S, Greenspan RJ, Golden SS (2015) Giving time purpose: the Synechococcus elongatus clock in a broader network context. Annu Rev Genet 49:485–505. https://doi.org/10.1146/annurev-genet-111212-133227CrossRefPubMedPubMedCentral

Nguyen KD, Fentress SJ, Qiu Y, Yun K, Cox JS, Chawla A (2013) Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes. Science 341:1483–1488. https://doi.org/10.1126/science.1240636CrossRefPubMed

Adrover JM, Del Fresno C, Crainiciuc G et al (2019) A neutrophil timer coordinates immune defense and vascular protection. Immunity 50:390–402.e10. https://doi.org/10.1016/j.immuni.2019.01.002CrossRefPubMed

Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, Yao L, Sander LE, Chen CS, Kraus K, de Juan A, Hergenhan SM, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H, Scheiermann C (2017) Lymphocyte circadian clocks control lymph node trafficking and adaptive immune responses. Immunity 46:120–132. https://doi.org/10.1016/j.immuni.2016.12.011CrossRefPubMedPubMedCentral

Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV (2013) TH17 cell differentiation is regulated by the circadian clock. Science 342:727–730. https://doi.org/10.1126/science.1243884CrossRefPubMedPubMedCentral

Teng F, Goc J, Zhou L et al (2019) A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut. Sci Immunol 4:eaax1215. https://doi.org/10.1126/sciimmunol.aax1215CrossRefPubMedPubMedCentral

Wang Q, Robinette ML, Billon C et al (2019) Circadian rhythm-dependent and circadian rhythm-independent impacts of the molecular clock on type 3 innate lymphoid cells. Sci Immunol 4:eaay7501. https://doi.org/10.1126/sciimmunol.aay7501CrossRefPubMedPubMedCentral

Godinho-Silva C, Domingues RG, Rendas M et al (2019) Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis. Nature:1–22. https://doi.org/10.1038/s41586-019-1579-3

10.

Panda S, Provencio I, Tu DC, Pires SS, Rollag MD, Castrucci AM, Pletcher MT, Sato TK, Wiltshire T, Andahazy M, Kay SA, van Gelder R, Hogenesch JB (2003) Melanopsin is required for non–image-forming photic responses in blind mice. Science 301:525–527. https://doi.org/10.1126/science.1086179CrossRefPubMed

11.

Mohawk JA, Green CB, Takahashi JS (2012) Central and peripheral circadian clocks in mammals. Annu Rev Neurosci 35:445–462. https://doi.org/10.1146/annurev-neuro-060909-153128CrossRefPubMedPubMedCentral

12.

Takahashi JS (2017) Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet 18:164–179. https://doi.org/10.1038/nrg.2016.150CrossRefPubMed

13.

Izumo M, Pejchal M, Schook AC, Lange RP, Walisser JA, Sato TR, Wang X, Bradfield CA, Takahashi JS (2014) Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant. Elife 3:350. https://doi.org/10.7554/eLife.04617CrossRef

14.

Hastings MH, Reddy AB, Maywood ES (2003) A clockwork web: circadian timing in brain and periphery, in health and disease. Nat Rev Neurosci 4:649–661. https://doi.org/10.1038/nrn1177CrossRefPubMed

15.

Kyriacou CP, Hastings MH (2010) Circadian clocks: genes, sleep, and cognition. Trends Cogn Sci (Regul Ed) 14:259–267. https://doi.org/10.1016/j.tics.2010.03.007CrossRef

16.

King DP, Zhao Y, Sangoram AM, Wilsbacher LD, Tanaka M, Antoch MP, Steeves TDL, Vitaterna MH, Kornhauser JM, Lowrey PL, Turek FW, Takahashi JS (1997) Positional cloning of the mouse circadian clock gene. Cell 89:641–653. https://doi.org/10.1016/s0092-8674(00)80245-7CrossRefPubMedPubMedCentral

17.

Gekakis N, Staknis D, Nguyen HB et al (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280:1564–1569. https://doi.org/10.1126/science.280.5369.1564CrossRefPubMed

18.

Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM (1999) mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98:193–205. https://doi.org/10.1016/s0092-8674(00)81014-4CrossRefPubMed

19.

Shearman LP, Sriram S, Weaver DR et al (2000) Interacting molecular loops in the mammalian circadian clock. Science 288:1013–1019. https://doi.org/10.1126/science.288.5468.1013CrossRefPubMed

20.

Ye R, Selby CP, Ozturk N, Annayev Y, Sancar A (2011) Biochemical analysis of the canonical model for the mammalian circadian clock. J Biol Chem 286:25891–25902. https://doi.org/10.1074/jbc.M111.254680CrossRefPubMedPubMedCentral

21.

Ye R, Selby CP, Chiou Y-Y, Ozkan-Dagliyan I, Gaddameedhi S, Sancar A (2014) Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock. Genes Dev 28:1989–1998. https://doi.org/10.1101/gad.249417.114CrossRefPubMedPubMedCentral

22.

Preitner N, Damiola F, Lopez-Molina L et al (2002) The orphan nuclear receptor REV-ERBα controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110:251–260. https://doi.org/10.1016/s0092-8674(02)00825-5CrossRefPubMed

23.

Sato TK, Panda S, Miraglia LJ, Reyes TM, Rudic RD, McNamara P, Naik KA, FitzGerald GA, Kay SA, Hogenesch JB (2004) A functional genomics strategy reveals Rorα as a component of the mammalian circadian clock. Neuron 43:527–537. https://doi.org/10.1016/j.neuron.2004.07.018CrossRefPubMed

24.

Guillaumond F, Dardente H, Giguère V, Cermakian N (2005) Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors. J Biol Rhythms 20:391–403. https://doi.org/10.1177/0748730405277232CrossRefPubMed

25.

Ripperger JA, Shearman LP, Reppert SM, Schibler U (2000) CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP. Genes Dev 14:679–689PubMedPubMedCentral

26.

Mitsui S, Yamaguchi S, Matsuo T, Ishida Y, Okamura H (2001) Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism. Genes Dev 15:995–1006. https://doi.org/10.1101/gad.873501CrossRefPubMedPubMedCentral

27.

Ueda HR, Hayashi S, Chen W, Sano M, Machida M, Shigeyoshi Y, Iino M, Hashimoto S (2005) System-level identification of transcriptional circuits underlying mammalian circadian clocks. Nat Genet 37:187–192. https://doi.org/10.1038/ng1504CrossRefPubMed

28.

Oishi K, Miyazaki K, Kadota K, Kikuno R, Nagase T, Atsumi GI, Ohkura N, Azama T, Mesaki M, Yukimasa S, Kobayashi H, Iitaka C, Umehara T, Horikoshi M, Kudo T, Shimizu Y, Yano M, Monden M, Machida K, Matsuda J, Horie S, Todo T, Ishida N (2003) Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes. J Biol Chem 278:41519–41527. https://doi.org/10.1074/jbc.M304564200CrossRefPubMed

29.

Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Alenghat T, Liu XS, Lazar MA (2011) A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science 331:1315–1319. https://doi.org/10.1126/science.1198125CrossRefPubMedPubMedCentral

30.

Kuang Z, Wang Y, Li Y, Ye C, Ruhn KA, Behrendt CL, Olson EN, Hooper LV (2019) The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3. Science 365:1428–1434. https://doi.org/10.1126/science.aaw3134CrossRefPubMedPubMedCentral

31.

Belden WJ, Dunlap JC (2008) SIRT1 is a circadian deacetylase for core clock components. Cell 134:212–214. https://doi.org/10.1016/j.cell.2008.07.010CrossRefPubMedPubMedCentral

32.

Green CB, Takahashi JS, Bass J (2008) The meter of metabolism. Cell 134:728–742. https://doi.org/10.1016/j.cell.2008.08.022CrossRefPubMedPubMedCentral

33.

McLoughlin SC, Haines P, FitzGerald GA (2015) Clocks and cardiovascular function. Meth Enzymol 552:211–228. https://doi.org/10.1016/bs.mie.2014.11.029CrossRef

34.

Tsang AH, Astiz M, Friedrichs M, Oster H (2016) Endocrine regulation of circadian physiology. J Endocrinol 230:R1–R11. https://doi.org/10.1530/JOE-16-0051CrossRefPubMed

35.

Hemmers S, Rudensky AY (2015) The cell-intrinsic circadian clock is dispensable for lymphocyte differentiation and function. Cell Rep 11:1339–1349. https://doi.org/10.1016/j.celrep.2015.04.058CrossRefPubMedPubMedCentral

36.

Yu X, Wang Y, Deng M, Li Y, Ruhn KA, Zhang CC, Hooper LV (2014) The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor. Elife 3:945–920. https://doi.org/10.7554/eLife.04406CrossRef

37.

Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, Shibata N, Grunberg S, Sinha R, Zahm AM, Tardif MR, Sathaliyawala T, Kubota M, Farber DL, Collman RG, Shaked A, Fouser LA, Weiner DB, Tessier PA, Friedman JR, Kiyono H, Bushman FD, Chang KM, Artis D (2012) Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science 336:1321–1325. https://doi.org/10.1126/science.1222551CrossRefPubMedPubMedCentral

38.

Shirasu-Hiza MM, Dionne MS, Pham LN, Ayres JS, Schneider DS (2007) Interactions between circadian rhythm and immunity in Drosophila melanogaster. Curr Biol 17:R353–R355. https://doi.org/10.1016/j.cub.2007.03.049CrossRefPubMed

39.

Edgar RS, Stangherlin A, Nagy AD, Nicoll MP, Efstathiou S, O’Neill JS, Reddy AB (2016) Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. Proc Natl Acad Sci USA 113:10085–10,090. https://doi.org/10.1073/pnas.1601895113CrossRefPubMed

40.

Hopwood TW, Hall S, Begley N, Forman R, Brown S, Vonslow R, Saer B, Little MC, Murphy EA, Hurst RJ, Ray DW, MacDonald AS, Brass A, Bechtold DA, Gibbs JE, Loudon AS, Else KJ (2018) The circadian regulator BMAL1 programmes responses to parasitic worm infection via a dendritic cell clock. Sci Rep 8:1–13. https://doi.org/10.1038/s41598-018-22021-5CrossRef

41.

Bellet MM, Deriu E, Liu JZ, Grimaldi B, Blaschitz C, Zeller M, Edwards RA, Sahar S, Dandekar S, Baldi P, George MD, Raffatellu M, Sassone-Corsi P (2013) Circadian clock regulates the host response to Salmonella. Proc Natl Acad Sci USA 110:9897–9902. https://doi.org/10.1073/pnas.1120636110CrossRefPubMed

42.

Hirako IC, Assis PA, Hojo-Souza NS et al (2018) Daily rhythms of TNFα expression and food intake regulate synchrony of Plasmodium stages with the host circadian cycle. Cell Host Microbe 23:796–808.e6. https://doi.org/10.1016/j.chom.2018.04.016CrossRefPubMedPubMedCentral

43.

Rijo-Ferreira F, Acosta-Rodríguez VA, Abel JH et al (2020) The malaria parasite has an intrinsic clock. Science 368:746–753. https://doi.org/10.1126/science.aba2658CrossRefPubMedPubMedCentral

44.

Wang Y, Kuang Z, Yu X, Ruhn KA, Kubo M, Hooper LV (2017) The intestinal microbiota regulates body composition through NFIL3 and the circadian clock. Science 357:912–916. https://doi.org/10.1126/science.aan0677CrossRefPubMedPubMedCentral

45.

Mukherji A, Kobiita A, Ye T, Chambon P (2013) Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs. 1–16. https://doi.org/10.1016/j.cell.2013.04.020

46.

Leone V, Gibbons SM, Martinez K, Hutchison AL, Huang EY, Cham CM, Pierre JF, Heneghan AF, Nadimpalli A, Hubert N, Zale E, Wang Y, Huang Y, Theriault B, Dinner AR, Musch MW, Kudsk KA, Prendergast BJ, Gilbert JA, Chang EB (2015) Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. Cell Host Microbe 17:681–689. https://doi.org/10.1016/j.chom.2015.03.006CrossRefPubMedPubMedCentral

47.

Hooper LV, Stappenbeck TS, Hong CV, Gordon JI (2003) Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol 4:269–273. https://doi.org/10.1038/ni888CrossRefPubMed

48.

Cash HL, Whitham CV, Behrendt CL, Hooper LV (2006) Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313:1126–1130. https://doi.org/10.1126/science.1127119CrossRefPubMedPubMedCentral

49.

Propheter DC, Chara AL, Harris TA, Ruhn KA, Hooper LV (2017) Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium. Proc Natl Acad Sci USA 114:11027–11033. https://doi.org/10.1073/pnas.1711395114CrossRefPubMed

50.

Bäckhed F, Ding H, Wang T et al (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA 101:15718–15723. https://doi.org/10.1073/pnas.0407076101CrossRefPubMed

51.

Bäckhed F, Manchester JK, Semenkovich CF, Gordon JI (2007) Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci USA 104:979–984. https://doi.org/10.1073/pnas.0605374104CrossRefPubMed

52.

Ley RE, Bäckhed F, Turnbaugh P et al (2005) Obesity alters gut microbial ecology. Proc Natl Acad Sci USA 102:11070–11075. https://doi.org/10.1073/pnas.0504978102CrossRefPubMed

53.

Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, Egholm M, Henrissat B, Heath AC, Knight R, Gordon JI (2009) A core gut microbiome in obese and lean twins. Nature 457:480–484. https://doi.org/10.1038/nature07540CrossRefPubMed

54.

Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444:1027–1031. https://doi.org/10.1038/nature05414CrossRefPubMed

55.

Thaiss CA, Zeevi D, Levy M, Zilberman-Schapira G, Suez J, Tengeler AC, Abramson L, Katz MN, Korem T, Zmora N, Kuperman Y, Biton I, Gilad S, Harmelin A, Shapiro H, Halpern Z, Segal E, Elinav E (2014) Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell 159:514–529. https://doi.org/10.1016/j.cell.2014.09.048CrossRefPubMed

56.

Zarrinpar A, Chaix A, Yooseph S, Panda S (2014) Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. Cell Metab 20:1006–1017. https://doi.org/10.1016/j.cmet.2014.11.008CrossRefPubMedPubMedCentral

57.

Thaiss CA, Levy M, Korem T, Dohnalová L, Shapiro H, Jaitin DA, David E, Winter DR, Gury-BenAri M, Tatirovsky E, Tuganbaev T, Federici S, Zmora N, Zeevi D, Dori-Bachash M, Pevsner-Fischer M, Kartvelishvily E, Brandis A, Harmelin A, Shibolet O, Halpern Z, Honda K, Amit I, Segal E, Elinav E (2016) Microbiota diurnal rhythmicity programs host transcriptome oscillations. Cell 167:1495–1510. https://doi.org/10.1016/j.cell.2016.11.003CrossRefPubMed

58.

Koike N, Yoo S-H, Huang H-C, Kumar V, Lee C, Kim TK, Takahashi JS (2012) Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Science 338:349–354. https://doi.org/10.1126/science.1226339CrossRefPubMedPubMedCentral

59.

Liang X, Bushman FD, FitzGerald GA (2015) Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock. Proc Natl Acad Sci USA 112:10479–10484. https://doi.org/10.1073/pnas.1501305112CrossRefPubMed

60.

Kohsaka A, Laposky AD, Ramsey KM, Estrada C, Joshu C, Kobayashi Y, Turek FW, Bass J (2007) High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab 6:414–421. https://doi.org/10.1016/j.cmet.2007.09.006CrossRefPubMed

61.

Joyce SA, MacSharry J, Casey PG, Kinsella M, Murphy EF, Shanahan F, Hill C, Gahan CGM (2014) Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proc Natl Acad Sci USA 111:7421–7426. https://doi.org/10.1073/pnas.1323599111CrossRefPubMed

62.

Joyce SA, Shanahan F, Hill C, Gahan CG (2014) Bacterial bile salt hydrolase in host metabolism: Potential for influencing gastrointestinal microbe-host crosstalk. Gut Microbes 5:669–674. https://doi.org/10.4161/19490976.2014.969986CrossRefPubMedPubMedCentral

63.

Govindarajan K, MacSharry J, Casey PG, Shanahan F, Joyce SA, Gahan CGM (2016) Unconjugated bile acids influence expression of circadian genes: a potential mechanism for microbe-host crosstalk. PLoS One 11:e0167319. https://doi.org/10.1371/journal.pone.0167319CrossRefPubMedPubMedCentral

64.

Zimmermann M, Zimmermann-Kogadeeva M, Wegmann R, Goodman AL (2019) Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature 570:462–467. https://doi.org/10.1038/s41586-019-1291-3CrossRefPubMedPubMedCentral

65.

Bechtold DA, Loudon ASI (2013) Hypothalamic clocks and rhythms in feeding behaviour. Trends Neurosci 36:74–82. https://doi.org/10.1016/j.tins.2012.12.007CrossRefPubMed

66.

Knutsson A, Bøggild H (2010) Gastrointestinal disorders among shift workers. Scand J Work Environ Health 36:85–95CrossRef

67.

Mohren DCL, Jansen NWH, Kant IJ, Galama JMD, van den Brandt PA, Swaen GMH (2002) Prevalence of common infections among employees in different work schedules. J Occup Environ Med 44:1003–1011CrossRef

68.

Bechtold DA, Gibbs JE, Loudon ASI (2010) Circadian dysfunction in disease. Trends in Pharmacological Sciences 31:191–198. https://doi.org/10.1016/j.tips.2010.01.002CrossRefPubMed

69.

Swanson GR, Burgess HJ, Keshavarzian A (2011) Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare? Expert Rev Clin Immunol 7:29–36. https://doi.org/10.1586/eci.10.83CrossRefPubMedPubMedCentral

70.

Reid KJ, Baron KG, Zee PC (2014) Meal timing influences daily caloric intake in healthy adults. Nutr Res 34:930–935. https://doi.org/10.1016/j.nutres.2014.09.010CrossRefPubMedPubMedCentral

71.

Silver AC, Arjona A, Walker WE, Fikrig E (2012) The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity. Immunity 36:251–261. https://doi.org/10.1016/j.immuni.2011.12.017CrossRefPubMedPubMedCentral

Titel: Interactions among microbes, the immune system, and the circadian clock
verfasst von: John F. Brooks II
Lora V. Hooper
Publikationsdatum: 08.10.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Seminars in Immunopathology / Ausgabe 6/2020
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-020-00820-1

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