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Neurological Sciences

Erschienen in:

16.11.2019 | Original Article

Interictal epileptiform discharges on electroencephalography in children with methylenetetrahydrofolate reductase (MTHFR) polymorphisms

verfasst von: Elif Karatoprak, Gulhan Sozen, Kutluhan Yılmaz, Işıl Ozer

Erschienen in: Neurological Sciences | Ausgabe 3/2020

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Abstract

Objective

Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism. MTHFR C677T and A1298C polymorphisms are best-defined variants of MTHFR that were reported to be associated with epilepsy development. The aim of the study was to determine the incidence of interictal epileptiform discharges on electroencephalography (EEG) in asymptomatic children with C677T and A1298C polymorphisms who had no history of seizure.

Methods

Children with MTHFR C677T or A1298C polymorphisms who had normal neurological examination without a history of seizure were included in the study. Blood samples for serum folate, vitamin B12, and homocysteine levels were analyzed. Sleep and awake electroencephalograms (EEG) were recorded.

Results

A total of 102 children (50 girls and 52 boys) with a mean age of 59.4 ± 58.7 months were included in the study. Interictal epileptiform EEG discharges were detected in 3 children (2.9%).

Conclusion

There was no increase in the prevalence of interictal epileptiform discharges in seizure-free and asymptomatic children with MTHFR C677T and A1298C polymorphisms.

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Titel: Interictal epileptiform discharges on electroencephalography in children with methylenetetrahydrofolate reductase (MTHFR) polymorphisms
verfasst von: Elif Karatoprak
Gulhan Sozen
Kutluhan Yılmaz
Işıl Ozer
Publikationsdatum: 16.11.2019
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 3/2020
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-04119-4

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