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Arthritis Research & Therapy
Erschienen in: Arthritis Research & Therapy 4/2010

01.08.2010 | Review

Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management

verfasst von: Flavia V Castelino, John Varga

Erschienen in: Arthritis Research & Therapy | Ausgabe 4/2010

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Abstract

Interstitial lung disease (ILD) is a challenging clinical entity associated with multiple connective tissue diseases, and is a significant cause of morbidity and mortality. Effective therapies for connective tissue disease-associated interstitial lung disease (CTD-ILD) are still lacking. Multidisciplinary clinics dedicated to the early diagnosis and improved management of patients with CTD-ILD are now being established. There is rapid progress in understanding and identifying the effector cells, the proinflammatory and profibrotic mediators, and the pathways involved in the pathogenesis of CTD-ILD. Serum biomarkers may provide new insights as risk factors for pulmonary fibrosis and as measures of disease progression. Despite these recent advances, the management of patients with CTD-ILD remains suboptimal. Further studies are therefore urgently needed to better understand these conditions, and to develop effective therapeutic interventions.
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Metadaten
Titel
Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management
verfasst von
Flavia V Castelino
John Varga
Publikationsdatum
01.08.2010
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 4/2010
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3097

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