Erschienen in:
01.12.2004 | Case Report
Intravenous cyclophosphamide therapy in a case with refractory thrombotic microangiopathic hemolytic anemia and SLE
verfasst von:
Jun Akaogi, Noriko Akasaka, Hidehiro Yamada, Nobuaki Hama, Minoru Satoh, Cody Nichols, Shoichi Ozaki
Erschienen in:
Clinical Rheumatology
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Ausgabe 6/2004
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Abstract
The case of a 27-year-old woman who simultaneously presented with SLE and severe refractory thrombotic microangiopathic hemolytic anemia (TMHA) is reported. She had extremely high levels of platelet-associated IgG (PAIgG), and her TMHA was refractory to plasma exchange and corticosteroid therapy. However, the TMHA was effectively controlled by i.v. cyclophosphamide therapy. ITP and TTP are generally considered distinct diseases; however, TMHA may occur secondary to platelet aggregation via autoimmune mechanisms in certain cases. Immunosuppressive therapy at an early stage of the disease may be beneficial in refractory cases of TMHA with autoimmune features.