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01.05.2014 | Original Article

Intravesical instillations with polydeoxyribonucleotides reduce symptoms of radiation-induced cystitis in patients treated with radiotherapy for pelvic cancer: a pilot study

verfasst von: Pierluigi Bonfili, Pietro Franzese, Francesco Marampon, Maria Emilia La Verghetta, Silvia Parente, Manuela Cerasani, Daniela Di Genova, Marta Mancini, Francesca Vittorini, Giovanni Luca Gravina, Valeria Ruggieri, Mario Di Staso, Vladimir M. Popov, Vincenzo Tombolini, Ernesto Di Cesare

Erschienen in: Supportive Care in Cancer | Ausgabe 5/2014

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Abstract

Purpose

Chronic radiation cystitis (CRC) is a serious complication that can arise in patients with pelvic malignancies treated with radiotherapy. Polydeoxyribonucleotides (PDRNs) are known to reduce inflammation and improve tissue perfusion and angiogenesis. In this manuscript, we describe our observational experience regarding intravesical instillation of PDRNs in improving symptoms of CRC in subjects unresponsiveness to conventional medical therapy.

Methods

Eight patients with persistent and/or worsening CRC symptoms, despite conventional therapy, received biweekly intravesical instillation of PDRNs for two consecutive months. Symptoms were scored according to the Late Effects of Normal Tissues-Subjective, Objective, Management, Analytic (LENT-SOMA) scale, before, at the end, and after 4 months following the PDRNs treatment.

Results

Four months after instillations, a significant improvement in the subjective perception of CRC symptoms was experienced by participants. The mean LENT-SOMA score was reduced from 1.16 + 0.26 before to 0.34 + 0.035 after 4 months from instillations (p < 0.001). No adverse effect related to instillations was reported.

Conclusions

Subjective perception of persistent and/or worsening CRC symptoms, despite conventional therapy, is improved after intravesical instillation with PDRNs without adverse events. Even though we deduced suggestive insights, the results need to be collected and verified from a large-scale study.

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Titel: Intravesical instillations with polydeoxyribonucleotides reduce symptoms of radiation-induced cystitis in patients treated with radiotherapy for pelvic cancer: a pilot study
verfasst von: Pierluigi Bonfili
Pietro Franzese
Francesco Marampon
Maria Emilia La Verghetta
Silvia Parente
Manuela Cerasani
Daniela Di Genova
Marta Mancini
Francesca Vittorini
Giovanni Luca Gravina
Valeria Ruggieri
Mario Di Staso
Vladimir M. Popov
Vincenzo Tombolini
Ernesto Di Cesare
Publikationsdatum: 01.05.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 5/2014
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-013-2051-9

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Intravesical instillations with polydeoxyribonucleotides reduce symptoms of radiation-induced cystitis in patients treated with radiotherapy for pelvic cancer: a pilot study