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Comparative Clinical Pathology

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01.09.2015 | Original Article

Introduce Indian gray mongoose (Herpestes edwardsii): as a successful animal model for influenza virus infection (a preliminary study)

verfasst von: M. Mansourian, M. Namavari, A. Rahimian, S. Nazifi, M. Lotfi, S. Sadeghzadeh

Erschienen in: Comparative Clinical Pathology | Ausgabe 5/2015

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Abstract

Indian gray mongoose (Herpestes edwardsii) is native to a large geographic area, but there is a lack of data about the biology of this animal. In the present investigation, the possibility of experimental infection with influenza (H₁N₁) virus in mongoose was studied. Ten H. edwardsii were gathered. Two animals were maintained without inoculation, and others were inoculated by nasal route and then euthanized in different situations. The inoculated group showed clinical signs of pulmonary disorder. Necropsy findings and histopathologic investigation revealed a severe interstitial pneumonia. In the next step, the virus shedding and direct transmission from the infected animal to others were checked. The results showed that virus shedding can occur. To our knowledge, this is the first description of Indian gray mongoose as an animal model for evaluating the experimental influenza virus infection, and it is a successful model for influenza research.

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Titel: Introduce Indian gray mongoose (Herpestes edwardsii): as a successful animal model for influenza virus infection (a preliminary study)
verfasst von: M. Mansourian
M. Namavari
A. Rahimian
S. Nazifi
M. Lotfi
S. Sadeghzadeh
Publikationsdatum: 01.09.2015
Verlag: Springer London
Erschienen in: Comparative Clinical Pathology / Ausgabe 5/2015
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-014-2048-x

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Introduce Indian gray mongoose (Herpestes edwardsii): as a successful animal model for influenza virus infection (a preliminary study)

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Abstract

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