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Breast Cancer Research and Treatment

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01.06.2012 | Preclinical Study

Investigation of human JC and BK polyomaviruses in breast carcinomas

verfasst von: Mohamed Hachana, Khaled Amara, Sonia Ziadi, Riadh Ben Gacem, Sadok Korbi, Mounir Trimeche

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 3/2012

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Abstract

We have previously showed the presence of the simian virus 40 (SV40) and the mouse mammary tumor virus (MMTV)-like in a significant proportions of Tunisian breast carcinomas. However, to date there are no published studies concerning evaluation of the possible implication of the human polyomaviruses JC (JCV) and BK (BKV) in breast carcinomas. The presence of JCV and BKV DNA was investigated by PCR in a 123 primary breast carcinomas and matched adjacent non-tumor breast tissues. The results were correlated to clinicopathological and virological parameters. JCV T-antigen DNA was detected in 23% of breast carcinoma cases; however, all cases were negative for BKV. JCV T antigen PCR products were further confirmed as authentic JCV genome by direct sequencing. JCV was found in invasive ductal carcinomas (28/112 cases) but not in invasive lobular carcinomas (0/5) or medullary carcinomas (0/6). JCV DNA presence correlates inversely with the expression of estrogen (P = 0.022) and progesterone (P = 0.008) receptors. JCV DNA presence correlates also with “triple negative” phenotype (P = 0.021). With regard to virological data, a trend toward an inverse correlation was noted between the presence of JCV and SV40 (P = 0.06). Moreover, significant correlation was found between multiple viral infection (JCV, and/or SV40, and/or MMTV-like in the same tumor) and “triple negative” phenotype (P = 0.001) and also with p53 accumulation (P = 0.028). To the best of our knowledge, this is the first study demonstrating the presence of JCV in a subset of breast carcinomas. Also our results suggest that “triple negative” breast carcinomas are viral-related tumors.

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Titel: Investigation of human JC and BK polyomaviruses in breast carcinomas
verfasst von: Mohamed Hachana
Khaled Amara
Sonia Ziadi
Riadh Ben Gacem
Sadok Korbi
Mounir Trimeche
Publikationsdatum: 01.06.2012
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 3/2012
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-011-1876-5

Springer Medizin

Investigation of human JC and BK polyomaviruses in breast carcinomas

Abstract

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Springer Medizin

Abstract

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