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01.12.2009 | Original Paper

Involvement of FcɛR1β gene polymorphisms in susceptibility to atopy in Korean children with asthma

verfasst von: Eun Soo Kim, Seung-Hyun Kim, Kyung Won Kim, Hae-Sim Park, Eun Soon Shin, Jong Eun Lee, Myung Hyun Sohn, Kyu-Earn Kim

Erschienen in: European Journal of Pediatrics | Ausgabe 12/2009

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Abstract

Introduction

IgE-dependent activation of mast cells and basophils through the high-affinity IgE receptor (FcɛR1) is involved in the pathogenesis of allergen-induced immune responsiveness in atopic disease including bronchial asthma.

Materials and methods

We genotyped 650 children for allelic determinants at two polymorphic sites, −109T/C and E237G, in the FcɛR1β gene by SNP-IT™ assays using the SNP stream 25K™ system.

Results

Distributions of the genotype and allele frequencies of FcɛR1β −109T/C and E237G polymorphisms were significantly associated with atopy (P < 0.05) and elevated serum IgE levels. However, differences in the E237G polymorphism did not reach statistical significance after adjustment for multiple comparisons. The genotypes TC or CC at −109T/C were associated with decreased forced expiratory flow_25–75% in children with asthma (P < 0.05), but this did not reach statistical significance after correction for multiple comparisons. In addition, haplotype 1 (T-A) was associated with atopy susceptibility (P = 0.0069). Analysis of genotype distributions of haplotypes demonstrated a significantly lower PC₂₀ for homozygous −/− diploids compared with homozygous Ht1/Ht1 (P = 0.0261).

Conclusion

Polymorphisms in the FcɛR1β gene confer susceptibility to atopy in Korean children and may have a disease-modifying effect on airways of asthmatic patients.

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Titel: Involvement of FcɛR1β gene polymorphisms in susceptibility to atopy in Korean children with asthma
verfasst von: Eun Soo Kim
Seung-Hyun Kim
Kyung Won Kim
Hae-Sim Park
Eun Soon Shin
Jong Eun Lee
Myung Hyun Sohn
Kyu-Earn Kim
Publikationsdatum: 01.12.2009
Verlag: Springer-Verlag
Erschienen in: European Journal of Pediatrics / Ausgabe 12/2009
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-009-0960-x

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Involvement of FcɛR1β gene polymorphisms in susceptibility to atopy in Korean children with asthma